College Football Top 25 Week 4 2024 Predictions, Betting Odds & TV Schedule

Updated Sep. 21, 2024 10:24 p.m. ET

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There are 18 games featuring a ranked team on the Week 4 college football slate.

Check out our betting breakdown for college football's Week 4.

Check out the full college football schedule on FOX Sports! Or visit FOX Sports' college football hub for everything you need to make the most of this season's action.

Week 4 Betting Lines & Game Info

No. 22 Nebraska Cornhuskers vs. No. 24 Illinois Fighting Illini

Odds & Prediction

• Spread: Cornhuskers (-9)
• Moneyline: Cornhuskers -360, Fighting Illini +285
• Total: 42.5 points
• Prediction: Illinois 22, Nebraska 19

How to Watch

• Game Date: Friday, Sept. 20
• Game Time: 8:00 PM ET
• TV Channel: Watch Online: FOX
• Location: Lincoln, Nebraska
• Box Score

No. 21 Clemson Tigers vs. North Carolina State Wolfpack

Odds & Prediction

• Spread: Tigers (-17.5)
• Moneyline: Tigers -800, Wolfpack +550
• Total: 44 points
• Prediction: Clemson 31, NC State 27

How to Watch

• Game Date: Saturday, Sept. 21
• Game Time: 12:00 PM ET
• TV Channel: ABC
• Location: Berkeley, California
• Box Score

No. 3 Ohio State Buckeyes vs. Marshall Thundering Herd

Odds & Prediction

• Spread: Buckeyes (-39)
• Moneyline: Buckeyes , Thundering Herd
• Total: 55 points
• Prediction: Ohio State 36, Marshall 15

How to Watch

• Game Date: Saturday, Sept. 21
• Game Time: 12:00 PM ET
• TV Channel: Watch Online: FOX
• Location: Columbus, Ohio
• Box Score

No. 20 Iowa State Cyclones vs. Arkansas State Red Wolves

Odds & Prediction

• Spread: Cyclones (-20.5)
• Moneyline: Cyclones -1587, Red Wolves +900
• Total: 52 points
• Prediction: Iowa State 27, Arkansas State 17

How to Watch

• Game Date: Saturday, Sept. 21
• Game Time: 2:00 PM ET
• TV Channel: ESPN+
• Location: Ames, Iowa
• Box Score

No. 23 Northern Illinois Huskies vs. Buffalo Bulls

Odds & Prediction

• Spread: Huskies (-12)
• Moneyline: Huskies -521, Bulls +390
• Total: 43 points
• Prediction: Northern Illinois 21, Buffalo 13

How to Watch

• Game Date: Saturday, Sept. 21
• Game Time: 3:30 PM ET
• TV Channel: ESPN+
• Location: DeKalb, Illinois
• Box Score

No. 10 Penn State Nittany Lions vs. Kent State Golden Flashes

Odds & Prediction

• Spread: Nittany Lions (-49)
• Moneyline: Nittany Lions , Golden Flashes
• Total: 57.5 points
• Prediction: Penn State 46, Kent State 19

How to Watch

• Game Date: Saturday, Sept. 21
• Game Time: 3:30 PM ET
• TV Channel: BTN
• Location: University Park, Pennsylvania
• Box Score

No. 16 LSU Tigers vs. UCLA Bruins

Odds & Prediction

• Spread: Tigers (-22)
• Moneyline: Tigers -1786, Bruins +1000
• Total: 56.5 points
• Prediction: LSU 28, UCLA 22

How to Watch

• Game Date: Saturday, Sept. 21
• Game Time: 3:30 PM ET
• TV Channel: ABC
• Location: Baton Rouge, Louisiana
• Box Score

No. 19 Louisville Cardinals vs. Georgia Tech Yellow Jackets

Odds & Prediction

• Spread: Cardinals (-8.5)
• Moneyline: Cardinals -310, Yellow Jackets +250
• Total: 56 points
• Prediction: Louisville 33, Georgia Tech 24

How to Watch

• Game Date: Saturday, Sept. 21
• Game Time: 3:30 PM ET
• TV Channel: ESPN2
• Location: Louisville, Kentucky
• Box Score

No. 17 Notre Dame Fighting Irish vs. Miami (OH) RedHawks

Odds & Prediction

• Spread: Fighting Irish (-27)
• Moneyline: Fighting Irish -4545, RedHawks +1700
• Total: 44 points
• Prediction: Notre Dame 28, Miami (OH) 11

How to Watch

• Game Date: Saturday, Sept. 21
• Game Time: 3:30 PM ET
• TV Channel: NBC
• Location: South Bend, Indiana
• Box Score

No. 18 Michigan Wolverines vs. No. 11 USC Trojans

Odds & Prediction

• Spread: Trojans (-5)
• Moneyline: Trojans -192, Wolverines +160
• Total: 44 points
• Prediction: Michigan 24, USC 21

How to Watch

• Game Date: Saturday, Sept. 21
• Game Time: 3:30 PM ET
• TV Channel: CBS
• Location: Ann Arbor, Michigan
• Box Score

No. 14 Oklahoma State Cowboys vs. No. 12 Utah Utes

Odds & Prediction

• Spread: Cowboys (-1)
• Moneyline: Cowboys -115, Utes -105
• Total: 53 points
• Prediction: Oklahoma State 29, Utah 26

How to Watch

• Game Date: Saturday, Sept. 21
• Game Time: 4:00 PM ET
• TV Channel: Watch Online: FOX
• Location: Stillwater, Oklahoma
• Box Score

No. 7 Missouri Tigers vs. Vanderbilt Commodores

Odds & Prediction

• Spread: Tigers (-18)
• Moneyline: Tigers -1000, Commodores +650
• Total: 52.5 points
• Prediction: Missouri 39, Vanderbilt 15

How to Watch

• Game Date: Saturday, Sept. 21
• Game Time: 4:15 PM ET
• TV Channel: SEC Network
• Location: Columbia, Missouri
• Box Score

South Florida Bulls vs. No. 8 Miami (FL) Hurricanes

Odds & Prediction

• Spread: Hurricanes (-16.5)
• Moneyline: Hurricanes -847, Bulls +575
• Total: 65 points
• Prediction: Miami (FL) 33, South Florida 30

How to Watch

• Game Date: Saturday, Sept. 21
• Game Time: 7:00 PM ET
• TV Channel: ESPN
• Location: Tampa, Florida
• Box Score

No. 15 Oklahoma Sooners vs. No. 6 Tennessee Volunteers

Odds & Prediction

• Spread: Volunteers (-6.5)
• Moneyline: Volunteers -230, Sooners +190
• Total: 57 points
• Prediction: Oklahoma 30, Tennessee 25

How to Watch

• Game Date: Saturday, Sept. 21
• Game Time: 7:30 PM ET
• TV Channel: ABC
• Location: Norman, Oklahoma
• Box Score

No. 25 Texas A&M Aggies vs. Bowling Green Falcons

Odds & Prediction

• Spread: Aggies (-21)
• Moneyline: Aggies -1449, Falcons +850
• Total: 51 points
• Prediction: Texas A&M 28, Bowling Green 25

How to Watch

• Game Date: Saturday, Sept. 21
• Game Time: 7:30 PM ET
• TV Channel: SEC Network+
• Location: College Station, Texas
• Box Score

No. 5 Ole Miss Rebels vs. Georgia Southern Eagles

Odds & Prediction

• Spread: Rebels (-35)
• Moneyline: Rebels , Eagles
• Total: 68.5 points
• Prediction: Ole Miss 34, Georgia Southern 26

How to Watch

• Game Date: Saturday, Sept. 21
• Game Time: 7:45 PM ET
• TV Channel: SEC Network
• Location: Oxford, Mississippi
• Box Score

No. 1 Texas Longhorns vs. Louisiana-Monroe Warhawks

Odds & Prediction

• Spread: Longhorns (-43.5)
• Moneyline: Longhorns , Warhawks
• Total: 54.5 points
• Prediction: Texas 27, UL Monroe 19

How to Watch

• Game Date: Saturday, Sept. 21
• Game Time: 8:00 PM ET
• TV Channel: SEC Network+
• Location: Austin, Texas
• Box Score

BYU Cougars vs. No. 13 Kansas State Wildcats

Odds & Prediction

• Spread: Wildcats (-7)
• Moneyline: Wildcats -258, Cougars +210
• Total: 49.5 points
• Prediction: Kansas State 25, BYU 20

How to Watch

• Game Date: Saturday, Sept. 21
• Game Time: 10:30 PM ET
• TV Channel: ESPN
• Location: Provo, Utah
• Box Score

FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

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