USC vs. Michigan Prediction, Odds, Picks - September 21, 2024

Updated Sep. 19, 2024 3:06 p.m. ET

Data Skrive

Oddsmakers give the No. 11 USC Trojans (2-0) the edge when they visit the No. 18 Michigan Wolverines (2-1) on Saturday, September 21, 2024 in a matchup between Big Ten opponents at Michigan Stadium. USC is favored by 5.5 points. This game has an over/under of 44 points.

The Trojans' last contest was versus the Utah State Aggies, and they won by a score of 48-0. Last time out, the Wolverines defeated the Arkansas State Red Wolves, with 28-18 being the final score.

Keep up with college football all season on FOX Sports.

How will USC fare in tough Big Ten road test vs. Michigan? | The Herd

FOX Sports' Joel Klatt joins Colin Cowherd to break down USC-Michigan and how the Trojans will fare in a tough road test against the Wolverines at the Big House.

USC vs. Michigan Game Information & Odds

When: Saturday, September 21, 2024 at 3:30 p.m. ET
Location: Michigan Stadium in Ann Arbor, Michigan
TV: CBS
Live Box Score on FOX Sports

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USC vs Michigan Betting Information updated as of September 19, 2024, 2:46 p.m. ET.
Favorite	Spread (Odds)	Favorite Moneyline	Underdog Moneyline	Total	Over Moneyline	Under Moneyline
USC	-5.5 (-109)	-208	+170	44	-110	-112

USC vs. Michigan Prediction

Pick ATS: Michigan (+5.5)
Pick OU: Over (44)
Prediction: Michigan 23, USC 22

Predictions are made by the Data Skrive betting model.

Learn more about the USC Trojans vs. the Michigan Wolverines game on FOX Sports!

USC vs. Michigan Betting Insights

Based on the spread and over/under, the implied score for the tilt is Trojans 25, Wolverines 19.
The Trojans have a 67.5% chance to claim victory in this meeting based on the moneyline's implied probability. The Wolverines have a 37.0% implied probability.
USC has covered in each of its two games with a spread this season.
Michigan has compiled a 0-3-0 record against the spread this year.

USC vs. Michigan: 2024 Stats Comparison

	USC	Michigan
Off. Points per Game (Rank)	37.5 (81)	23.3 (89)
Def. Points per Game (Rank)	10 (10)	19.7 (63)
Turnovers Allowed (Rank)	1 (6)	7 (121)
Turnovers Forced (Rank)	2 (97)	3 (67)

USC 2024 Key Players

Name	Position	Stats
Jo'Quavious Marks	RB	171 YDS / 3 TD / 85.5 YPG / 5.9 YPC 6 REC / 46 REC YDS / 0 REC TD / 23.0 REC YPG
Miller Moss	QB	607 YDS (72.7%) / 2 TD / 0 INT
Quinten Joyner	RB	96 YDS / 2 TD / 48.0 YPG / 6.9 YPC
Ja'Kobi Lane	WR	5 REC / 66 YDS / 1 TD / 33.0 YPG
Kamari Ramsey	DB	10 TKL / 0.0 TFL / 1.0 SACK
Eric Gentry	LB	7 TKL / 3.0 TFL / 1.0 SACK
Mason Cobb	LB	4 TKL / 0.0 TFL / 1 INT / 1 PD
Easton Mascarenas	LB	5 TKL / 0.0 TFL / 1 INT / 1 PD

Michigan 2024 Key Players

Name	Position	Stats
Kalel Mullings	RB	270 YDS / 2 TD / 90.0 YPG / 7.5 YPC
Donovan Edwards	RB	150 YDS / 1 TD / 50.0 YPG / 4.2 YPC 4 REC / 13 REC YDS / 1 REC TD / 4.3 REC YPG
Colston Loveland	TE	19 REC / 187 YDS / 1 TD / 62.3 YPG
Alex Orji	QB	15 YDS (50.0%) / 2 TD / 0 INT 58 RUSH YDS / 0 RUSH TD / 19.3 RUSH YPG
Josaiah Stewart	DL	6 TKL / 3.0 TFL / 2.0 SACK
Ernest Hausmann	LB	11 TKL / 1.0 TFL / 1.0 SACK
Rayshaun Benny	DL	8 TKL / 2.0 TFL / 1.0 SACK
Makari Paige	DB	9 TKL / 0.0 TFL / 1 INT / 1 PD