USC vs. Michigan Prediction, Odds, Picks - September 21, 2024

Updated Sep. 21, 2024 3:07 p.m. ET

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The No. 11 USC Trojans (2-0) are 4.5-point favorites when they visit the No. 18 Michigan Wolverines (2-1) in a Big Ten matchup on Saturday, September 21, 2024 at Michigan Stadium. The point total is set at 44 for the outing.

Against the Utah State Aggies in their most recent contest, the Trojans won 48-0. The Wolverines won against the Arkansas State Red Wolves in their most recent game, 28-18.

Keep up with college football all season on FOX Sports.

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USC vs. Michigan Game Information & Odds

• When: Saturday, September 21, 2024 at 3:30 p.m. ET
• Location: Michigan Stadium in Ann Arbor, Michigan
• TV: CBS
• Live Box Score on FOX Sports

More College Football Predictions

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• Washington vs. Northwestern Predictions
• Iowa vs. Minnesota Predictions
• Boston College vs. Michigan State Predictions
• Oregon State vs. Purdue Predictions

USC vs. Michigan Prediction

• Pick ATS: Michigan (+4.5)
  
• Pick OU: Over (44)
  
• Prediction: Michigan 24, USC 21

Predictions are made by the Data Skrive betting model.

Learn more about the USC Trojans vs. the Michigan Wolverines game on FOX Sports!

Read More About This Game

• How to Watch USC vs. Michigan

USC vs. Michigan Betting Insights

• Based on the spread and over/under, the implied score for the game is Trojans 24, Wolverines 20.
• The Trojans have a 65.4% chance to collect the win in this game per the moneyline's implied probability. The Wolverines hold a 39.1% implied probability.
• USC has covered twice in two games with a spread this season.
• Michigan has put together a 0-3-0 record against the spread this season.

USC vs. Michigan: 2024 Stats Comparison

USC 2024 Key Players

Michigan 2024 Key Players

FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

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CFB - USC Trojans vs. Michigan Wolverines - 09/21/2024

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