Duke vs. Mount St. Mary's Prediction, Odds, Picks - NCAA Tournament First Round

Updated Mar. 21, 2025 3:27 p.m. ET

Data Skrive

The No. 1 seed Duke Blue Devils (31-3) will aim to beat the No. 16 seed Mount St. Mary's Mountaineers (23-12) in the opening round of the NCAA Tournament on Friday at Lenovo Center. This matchup tips off at 3:09 p.m. ET.

NCAA BK

NCAA TOURNMENT - FIRST ROUND

Duke Blue Devils DUKE

FINAL

Duke ^32-3

DUKE ^32-3

Mount St Mary's ^23-13

MSM ^23-13

Mount St. Mary's Mountaineers MSM

FINAL

DUKE -32.5 OVER 141.5

The Blue Devils are an immense favorite against the Mountaineers when the Blue Devils and the Mountaineers meet. The Blue Devils are favored by 32.5 points. The game features an over/under of 141.5.

Keep reading to get everything you need to know before betting on the Duke-Mount St. Mary's matchup.

Duke vs. Mount St. Mary's Game Information & Odds

When: Friday, March 21, 2025 at 3:09 p.m. ET
Where: Lenovo Center in Raleigh, North Carolina
How to watch on TV: CBS
Live boxscore on FOX Sports

Blue Devils vs Mountaineers Betting Information
Favorite	Spread	Favorite Spread Odds	Underdog Spread Odds	Total	Over Total Odds	Under Total Odds	Favorite Moneyline	Underdog Moneyline
Blue Devils	-32.5	-110	-110	141.5	-110	-120	-50000	+4000

Duke vs. Mount St. Mary's Prediction

Pick ATS: Mount St. Mary's (+32.5)
Pick OU: Over (141.5)
Prediction: Duke 87, Mount St. Mary's 56

Learn more about the Duke Blue Devils vs. the Mount St. Mary's Mountaineers game on FOX Sports!

Duke vs. Mount St. Mary's Betting Insights

Betting Line Implied Predictions

Per the spread and over/under, the implied score for the encounter is Blue Devils 87, Mountaineers 54.
The Blue Devils have a 99.8% chance to claim victory in this contest based on the moneyline's implied probability.
The Mountaineers have a 2.4% implied probability to come out on top.

Key Spread Facts

Duke is 22-12-0 ATS this season.
Mount St. Mary's has put together a 22-12-0 record against the spread this year.
Duke has been favored by 32.5 points or more two times this season, and covered the spread in one of those matchups.

Key Total Facts

The Blue Devils and their opponent have broken the 141.5-point mark 21 times this season.
Mountaineers games have gone over 141.5 points on 16 occasions this year.
The Blue Devils and Mountaineers combine to average 153.4 points per contest, which is 11.9 more than the total for this game.

Key Moneyline Facts

Duke has won 90.6% of its games this season when the moneyline favorite (29-3).
This season, Mount St. Mary's has won 12 out of the 19 games, or 63.2%, in which it has been the underdog.
Duke has played as a moneyline favorite of -50000 or shorter in just one game this season, and won.
Mount St. Mary's has not entered a game this season with longer moneyline odds than +4000.

Mount St. Mary's Mountaineers

MSM

Duke Blue Devils

DUKE

Duke vs. Mount St. Mary's: 2024-25 Stats Comparison

	Duke	Mount St. Mary's
Points Scored Per Game (Rank)	82.7 (15)	70.7 (264)
Points Allowed (Rank)	61.9 (7)	69.9 (111)
Rebounds (Rank)	10 (83)	8.7 (192)
3pt Made (Rank)	10.1 (22)	8 (146)
Assists (Rank)	16.7 (23)	15.1 (76)
Turnovers (Rank)	9.2 (15)	14.4 (356)

Duke 2024-25 Key Players

Blue Devils Leaders
Name	GP	PTS	REB	ASST	STL	BLK	3PM
Cooper Flagg	32	18.9	7.5	4.1	1.5	1.2	1.3
Kon Knueppel	34	14.4	4.1	2.7	1	0.2	2.2
Tyrese Proctor	33	12	3.2	2.2	0.9	0.1	2.2
Sion James	34	8.7	4.1	3.1	0.9	0.3	0.8
Khaman Maluach	34	8.3	6.8	0.4	0.2	1.2	0.1

Mount St. Mary's 2024-25 Key Players

Mountaineers Leaders
Name	GP	PTS	REB	ASST	STL	BLK	3PM
Dola Adebayo	35	13.4	6.9	1	0.9	1.1	0.6
Dallas Hobbs	29	12.7	3.6	3.3	0.9	0	1.9
Terrell Ard Jr.	21	10.9	7.2	2.2	1.1	0.4	0
Jedy Cordilia	34	10.4	7.3	1.1	0.4	0.8	0.1
Carmelo Pacheco	30	9.5	1.7	1.3	0.6	0.1	2.6