Houston vs. Gonzaga Prediction, Odds, Picks - NCAA Tournament Second Round

Updated Mar. 22, 2025 8:27 p.m. ET

Data Skrive

The No. 1 seed Houston Cougars (31-4) look to advance to the Sweet 16 of the NCAA Tournament when they meet the No. 8 seed Gonzaga Bulldogs (26-8) on Saturday at 8:40 p.m. ET.

NCAA BK

NCAA TOURNMENT - SECOND ROUND

Gonzaga Bulldogs GONZ

FINAL

GONZ +5.5 OVER 141.5

The Cougars head into their matchup against the Bulldogs as a 5.5-point favorite. The game's point total is set at 141.5.

Keep reading to get all you need to know before wagering on the Houston-Gonzaga matchup.

Houston vs. Gonzaga Game Information & Odds

When: Saturday, March 22, 2025 at 8:40 p.m. ET
Where: INTRUST Bank Arena in Wichita, Kansas
How to watch on TV: TNT
Live boxscore on FOX Sports

Cougars vs Bulldogs Betting Information
Favorite	Spread	Favorite Spread Odds	Underdog Spread Odds	Total	Over Total Odds	Under Total Odds	Favorite Moneyline	Underdog Moneyline
Cougars	-5.5	-110	-110	141.5	-110	-120	-218	+180

Houston vs. Gonzaga Prediction

Pick ATS: Gonzaga (+5.5)
Pick OU: Over (141.5)
Prediction: Houston 74, Gonzaga 71

Learn more about the Houston Cougars vs. the Gonzaga Bulldogs game on FOX Sports!

Houston vs. Gonzaga Betting Insights

Betting Line Implied Predictions

Per the spread and over/under, the implied score for the encounter is Cougars 74, Bulldogs 68.
The Cougars have a 68.6% chance to claim victory in this meeting per the moneyline's implied probability.
The Bulldogs sit with a 35.7% implied probability to come out on top.

Key Spread Facts

Houston has won 19 games against the spread this season, while failing to cover 15 times.
Gonzaga has put together a 15-19-0 ATS record so far this season.
When playing as at least 5.5-point favorites this season, Houston has an ATS record of 16-13.

Key Total Facts

The Cougars and their opponent have broken the 141.5-point mark seven times this year.
Bulldogs games have finished with over 141.5 points scored 26 times this season.
The total for this matchup is 141.5 points, 19.5 fewer than the combined scoring average of the two teams.

Key Moneyline Facts

Houston has compiled a 27-4 record in games when it was favored on the moneyline (winning 87.1% of those games).
This is the first time Gonzaga will play as an underdog this season.
When playing as a moneyline favorite with odds of -218 or shorter, Houston has gone 24-3 (88.9% win percentage).
Gonzaga has not entered a game this season with longer moneyline odds than +180.

Houston vs. Gonzaga: 2024-25 Stats Comparison

	Houston	Gonzaga
Points Scored Per Game (Rank)	74.3 (158)	86.7 (2)
Points Allowed (Rank)	57.9 (1)	69.6 (95)
Rebounds (Rank)	10.8 (40)	9.3 (142)
3pt Made (Rank)	8.1 (134)	7.5 (194)
Assists (Rank)	11.9 (294)	19.8 (1)
Turnovers (Rank)	8.6 (5)	9.2 (15)

Houston 2024-25 Key Players

Cougars Leaders
Name	GP	PTS	REB	ASST	STL	BLK	3PM
LJ Cryer	35	15.2	2.2	1.9	0.9	0.1	3
Emanuel Sharp	32	12.5	3.1	0.9	1.4	0	2.4
Milos Uzan	35	11.6	3	4.2	1	0.1	1.5
J'wan Roberts	32	10.7	6.2	1.6	1	0.7	0
Terrance Arceneaux	35	7.2	2.9	0.8	1	0.3	0.7

Gonzaga 2024-25 Key Players

Bulldogs Leaders
Name	GP	PTS	REB	ASST	STL	BLK	3PM
Graham Ike	34	17	7.4	1.4	0.6	0.6	0.3
Khalif Battle	34	13.5	3.6	1.5	1.1	0.1	1.6
Nolan Hickman	34	11.2	2.4	2.3	1	0.3	2.3
Braden Huff	34	11	3.4	1	0.3	0.6	0.2
Ryan Nembhard	34	10.6	3	9.7	1.7	0.1	1.1