Iowa State vs. Lipscomb Prediction, Odds, Picks - NCAA Tournament First Round

Updated Mar. 21, 2025 5:27 a.m. ET

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The No. 3 seed Iowa State Cyclones (24-9) and the No. 14 seed Lipscomb Bisons (25-9) will meet in the opening round of the NCAA Tournament on Friday at 1:30 p.m. ET. The contest airs on TNT.

NCAA BK

NCAA TOURNMENT - FIRST ROUND

Iowa State Cyclones ISU

5:30 PM

TNT

3

Iowa State ^24-9

ISU ^24-9

14

Lipscomb ^25-9

LIP ^25-9

Lipscomb Bisons LIP

ISU -14.5 TOTAL 143

The Cyclones head into their game against the Bisons as double-digit favorites. The Cyclones are favored by 14.5 points. The point total for the matchup is set at 143.5.

Keep scrolling to get the details before betting on the Iowa State-Lipscomb game.

Iowa State vs. Lipscomb Game Information & Odds

• When: Friday, March 21, 2025 at 1:30 p.m. ET
• Where: Fiserv Forum in Milwaukee, Wisconsin
• How to watch on TV: TNT
• Live boxscore on FOX Sports

Iowa State vs. Lipscomb Prediction

• Pick ATS: Lipscomb (+14.5)
  
• Pick OU: Over (143.5)
  
• Prediction: Iowa State 80, Lipscomb 67

Learn more about the Iowa State Cyclones vs. the Lipscomb Bisons game on FOX Sports!

Iowa State vs. Lipscomb Betting Insights

Betting Line Implied Predictions

• Per the spread and over/under, the implied score for the matchup is Cyclones 79, Bisons 64.
• The Cyclones have a 93.1% chance to claim victory in this game based on the moneyline's implied probability.
• The Bisons sit with an 11.1% implied probability to come out on top.

Key Spread Facts

• Iowa State has put together a 19-14-0 record against the spread this season.
• Lipscomb is 17-13-1 ATS this year.
• Iowa State has an ATS record of 5-6 when playing as at least 14.5-point favorites this season.
• Lipscomb has not covered the spread when an underdog by 14.5 points or more this year (in two opportunities).

Key Total Facts

• Cyclones games have finished with more than 143.5 points 16 times so far this season.
• Bisons games have gone over 143.5 points on 15 occasions this year.
• These two teams score a combined average of 159.7 points per game, higher than the total for this matchup by 16.2 points.

Key Moneyline Facts

• Iowa State has won 79.2% of its games this season when favored on the moneyline (19-5).
• Lipscomb has been underdogs in seven games this season and won two (28.6%) of those contests.
• In games it has played as a moneyline favorite with odds of -1351 or shorter, Iowa State has a record of 6-1 (85.7% win percentage).
• Lipscomb has played as an underdog of +800 or more once this season and lost that game.

Fri 5:30 PM

TNT

NCAA BK

SPREAD

TO WIN

TOTAL

14

Lipscomb Bisons

LIP

+14.5

+792

O 142.5

3

Iowa State Cyclones

ISU

-14.5

-1333

U 142.5

Iowa State vs. Lipscomb: 2024-25 Stats Comparison

Iowa State 2024-25 Key Players

Lipscomb 2024-25 Key Players

FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

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CBK - Lipscomb Bisons vs. Iowa State Cyclones - 03/21/2025

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