Iowa State vs. Ole Miss Prediction, Odds, Picks - NCAA Tournament Second Round

Updated Mar. 23, 2025 3:27 p.m. ET

Data Skrive

The No. 3 seed Iowa State Cyclones (25-9) try to book a trip to the Sweet 16 in an NCAA Tournament second-round matchup against the No. 6 seed Ole Miss Rebels (23-11) on Sunday at Fiserv Forum, beginning at 7:45 p.m. ET.

NCAA BK

NCAA TOURNMENT - SECOND ROUND

Iowa State Cyclones ISU

FINAL

MISS +5.5 OVER 144.5

The Cyclones enter their matchup against the Rebels as a 5.5-point favorite. The matchup features an over/under of 144.5.

Continue scrolling to get all you need to know ahead of wagering on the Iowa State-Ole Miss contest.

Iowa State vs. Ole Miss Game Information & Odds

When: Sunday, March 23, 2025 at 7:45 p.m. ET
Where: Fiserv Forum in Milwaukee, Wisconsin
How to watch on TV: truTV
Live boxscore on FOX Sports

Cyclones vs Rebels Betting Information
Favorite	Spread	Favorite Spread Odds	Underdog Spread Odds	Total	Over Total Odds	Under Total Odds	Favorite Moneyline	Underdog Moneyline
Cyclones	-5.5	-110	-110	144.5	-108	-112	-238	+195

Iowa State vs. Ole Miss Prediction

Pick ATS: Ole Miss (+5.5)
Pick OU: Over (144.5)
Prediction: Iowa State 76, Ole Miss 72

Learn more about the Iowa State Cyclones vs. the Ole Miss Rebels game on FOX Sports!

Iowa State vs. Ole Miss Betting Insights

Betting Line Implied Predictions

Per the spread and over/under, the implied score for the encounter is Cyclones 75, Rebels 70.
The Cyclones have a 70.4% chance to claim victory in this contest based on the moneyline's implied probability.
The Rebels hold a 33.9% implied probability to win.

Key Spread Facts

Iowa State has compiled a 20-14-0 ATS record so far this year.
Ole Miss is 17-17-0 ATS this year.
Iowa State has been favored by 5.5 points or more 28 times this season, and covered the spread in 17 of those matchups.
When playing as at least 5.5-point underdogs this year, Ole Miss has an ATS record of 3-3.

Key Total Facts

The Cyclones and their opponent have broken the 144.5-point mark 15 times this season.
Rebels games have gone over 144.5 points on 18 occasions this year.
These teams score 157.4 points per game combined, higher than the over/under for this matchup by 12.9.

Key Moneyline Facts

Iowa State has won 20 of 25 games when the moneyline favorite this season (80%).
This season, Ole Miss has won six out of the 15 games, or 40%, in which it has been the underdog.
In games it has played as a moneyline favorite with odds of -238 or shorter, Iowa State has a record of 20-4 (83.3% win percentage).
This season, Ole Miss has won one of its six games when it is the underdog by at least +195 on the moneyline.

Iowa State vs. Ole Miss: 2024-25 Stats Comparison

	Iowa State	Ole Miss
Points Scored Per Game (Rank)	80.4 (34)	77 (90)
Points Allowed (Rank)	67.7 (54)	71.5 (164)
Rebounds (Rank)	8.8 (181)	7.4 (302)
3pt Made (Rank)	7.6 (184)	8.2 (120)
Assists (Rank)	15.1 (75)	14.1 (135)
Turnovers (Rank)	11.5 (220)	8.7 (7)

Iowa State 2024-25 Key Players

Cyclones Leaders
Name	GP	PTS	REB	ASST	STL	BLK	3PM
Curtis Jones	33	17.1	4.2	2.3	1.2	0.2	2.5
Keshon Gilbert	29	13.4	3.5	4.1	1.7	0.1	0.9
Joshua Jefferson	34	12.9	7.4	3.2	2.1	0.8	0.5
Milan Momcilovic	27	11.7	3.3	0.9	0.4	0.3	2.3
Tamin Lipsey	33	10.8	2.6	3.2	2	0.2	1.2

Ole Miss 2024-25 Key Players

Rebels Leaders
Name	GP	PTS	REB	ASST	STL	BLK	3PM
Sean Pedulla	34	15	3.6	3.6	1.8	0.2	2.4
Jaemyn Brakefield	34	10.9	4.3	1.9	0.7	0.3	0.7
Malik Dia	34	10.5	5.7	0.8	0.7	0.9	0.8
Dre Davis	32	10.5	4.8	1.2	1	1	0.8
Jaylen Murray	34	10.5	2.2	3.5	1.4	0.2	1.7