College Football Top 25 Week 4 Predictions, Betting Odds & TV Schedule

Updated Sep. 23, 2023 8:24 p.m. ET

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Top-25 teams will be in action in 18 games on the Week 4 college football slate. That includes the No. 6 Ohio State Buckeyes taking on the No. 9 Notre Dame Fighting Irish at Notre Dame Stadium.

If you're looking for additional betting intel for Week 4 in college football, we have you covered with betting odds for each of the important games.

Week 4 Betting Lines & Game Info

Clemson Tigers vs. No. 4 Florida State Seminoles

Odds & Prediction

• Spread: Seminoles (-2)
• Moneyline: Seminoles -130, Tigers +110
• Total: 56 points
• Prediction: Florida State 30, Clemson 29

How to Watch

• Game Date: Saturday, September 23
• Game Time: 12:00 PM ET
• TV Channel: ABC
• Location: Berkeley, California

Cincinnati Bearcats vs. No. 16 Oklahoma Sooners

Odds & Prediction

• Spread: Sooners (-13.5)
• Moneyline: Sooners -520, Bearcats +390
• Total: 57.5 points
• Prediction: Oklahoma 31, Cincinnati 28

How to Watch

• Game Date: Saturday, September 23
• Game Time: 12:00 PM ET
• TV Channel: Watch Online: FOX
• Location: Cincinnati, Ohio

No. 11 Utah Utes vs. No. 22 UCLA Bruins

Odds & Prediction

• Spread: Utes (-3.5)
• Moneyline: Utes -175, Bruins +145
• Total: 50.5 points
• Prediction: UCLA 20, Utah 19

How to Watch

• Game Date: Saturday, September 23
• Game Time: 3:30 PM ET
• TV Channel: Watch Online: FOX
• Location: Salt Lake City, Utah

No. 13 Alabama Crimson Tide vs. No. 15 Ole Miss Rebels

Odds & Prediction

• Spread: Crimson Tide (-7)
• Moneyline: Crimson Tide -258, Rebels +210
• Total: 56 points
• Prediction: Alabama 29, Ole Miss 28

How to Watch

• Game Date: Saturday, September 23
• Game Time: 3:30 PM ET
• TV Channel: CBS
• Location: Tuscaloosa, Alabama

No. 10 Oregon Ducks vs. No. 19 Colorado Buffaloes

Odds & Prediction

• Spread: Ducks (-21)
• Moneyline: Ducks -950, Buffaloes +625
• Total: 70.5 points
• Prediction: Oregon 39, Colorado 30

How to Watch

• Game Date: Saturday, September 23
• Game Time: 3:30 PM ET
• TV Channel: ABC
• Location: Eugene, Oregon

Temple Owls vs. No. 20 Miami Hurricanes

Odds & Prediction

• Spread: Hurricanes (-23)
• Moneyline: Hurricanes -2400, Owls +1200
• Total: 46 points
• Prediction: Miami (FL) 32, Temple 21

How to Watch

• Game Date: Saturday, September 23
• Game Time: 3:30 PM ET
• TV Channel: ESPN2
• Location: Philadelphia, Pennsylvania

UConn Huskies vs. No. 18 Duke Blue Devils

Odds & Prediction

• Spread: Blue Devils (-22.5)
• Moneyline: Blue Devils -2100, Huskies +1100
• Total: 45 points
• Prediction: Duke 27, UConn 16

How to Watch

• Game Date: Saturday, September 23
• Game Time: 3:30 PM ET
• TV Channel: CBS Sports Network
• Location: East Hartford, Connecticut

No. 23 Tennessee Volunteers vs. UTSA Roadrunners

Odds & Prediction

• Spread: Volunteers (-24)
• Moneyline: Volunteers -1800, Roadrunners +1000
• Total: 59.5 points
• Prediction: Tennessee 27, UTSA 21

How to Watch

• Game Date: Saturday, September 23
• Game Time: 4:00 PM ET
• TV Channel: SEC Network
• Location: Knoxville, Tennessee

No. 12 LSU Tigers vs. Arkansas Razorbacks

Odds & Prediction

• Spread: Tigers (-17.5)
• Moneyline: Tigers -1000, Razorbacks +650
• Total: 55 points
• Prediction: LSU 31, Arkansas 26

How to Watch

• Game Date: Saturday, September 23
• Game Time: 7:00 PM ET
• TV Channel: ESPN
• Location: Baton Rouge, Louisiana

No. 21 Washington State Cougars vs. No. 14 Oregon State Beavers

Odds & Prediction

• Spread: Beavers (-3)
• Moneyline: Beavers -155, Cougars +130
• Total: 57.5 points
• Prediction: Washington State 30, Oregon State 25

How to Watch

• Game Date: Saturday, September 23
• Game Time: 7:00 PM ET
• TV Channel: Watch Online: FOX
• Location: Pullman, Washington

No. 25 Florida Gators vs. Charlotte 49ers

Odds & Prediction

• Spread: Gators (-28)
• Moneyline: Gators -5000, 49ers +1800
• Total: 48.5 points
• Prediction: Florida 31, Charlotte 20

How to Watch

• Game Date: Saturday, September 23
• Game Time: 7:00 PM ET
• TV Channel: SEC Network+
• Location: Gainesville, Florida

No. 1 Georgia Bulldogs vs. UAB Blazers

Odds & Prediction

• Spread: Bulldogs (-40.5)
• Moneyline: Bulldogs , Blazers
• Total: 56 points
• Prediction: Georgia 41, UAB 17

How to Watch

• Game Date: Saturday, September 23
• Game Time: 7:30 PM ET
• TV Channel: ESPN2
• Location: Athens, Georgia

Baylor Bears vs. No. 3 Texas Longhorns

Odds & Prediction

• Spread: Longhorns (-17)
• Moneyline: Longhorns -750, Bears +525
• Total: 48.5 points
• Prediction: Texas 30, Baylor 21

How to Watch

• Game Date: Saturday, September 23
• Game Time: 7:30 PM ET
• TV Channel: ABC
• Location: Waco, Texas

No. 7 Penn State Nittany Lions vs. No. 24 Iowa Hawkeyes

Odds & Prediction

• Spread: Nittany Lions (-14)
• Moneyline: Nittany Lions -650, Hawkeyes +470
• Total: 38.5 points
• Prediction: Penn State 28, Iowa 16

How to Watch

• Game Date: Saturday, September 23
• Game Time: 7:30 PM ET
• TV Channel: CBS
• Location: University Park, Pennsylvania

No. 9 Notre Dame Fighting Irish vs. No. 6 Ohio State Buckeyes

Odds & Prediction

• Spread: Buckeyes (-3.5)
• Moneyline: Buckeyes -166, Fighting Irish +140
• Total: 55.5 points
• Prediction: Ohio State 28, Notre Dame 25

How to Watch

• Game Date: Saturday, September 23
• Game Time: 7:30 PM ET
• TV Channel: NBC
• Location: South Bend, Indiana

Pittsburgh Panthers vs. No. 17 North Carolina Tar Heels

Odds & Prediction

• Spread: Tar Heels (-7)
• Moneyline: Tar Heels -265, Panthers +215
• Total: 49.5 points
• Prediction: North Carolina 24, Pittsburgh 21

How to Watch

• Game Date: Saturday, September 23
• Game Time: 8:00 PM ET
• TV Channel: ACC Network
• Location: Pittsburgh, Pennsylvania

No. 8 Washington Huskies vs. California Golden Bears

Odds & Prediction

• Spread: Huskies (-20.5)
• Moneyline: Huskies -1100, Golden Bears +700
• Total: 57 points
• Prediction: Washington 32, Cal 23

How to Watch

• Game Date: Saturday, September 23
• Game Time: 10:30 PM ET
• TV Channel: ESPN
• Location: Seattle, Washington

Arizona State Sun Devils vs. No. 5 USC Trojans

Odds & Prediction

• Spread: Trojans (-34)
• Moneyline: Trojans , Sun Devils
• Total: 62 points
• Prediction: USC 36, Arizona State 21

How to Watch

• Game Date: Saturday, September 23
• Game Time: 10:30 PM ET
• TV Channel: Watch Online: FOX
• Location: Tempe, Arizona

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