College Football Top 25 Week 4 Predictions, Betting Odds & TV Schedule
Top-25 teams will be in action in 18 games on the Week 4 college football slate. That includes the No. 6 Ohio State Buckeyes taking on the No. 9 Notre Dame Fighting Irish at Notre Dame Stadium.
If you're looking for additional betting intel for Week 4 in college football, we have you covered with betting odds for each of the important games.
Week 4 Betting Lines & Game Info
Clemson Tigers vs. No. 4 Florida State Seminoles
Odds & Prediction
- Spread: Seminoles (-2)
- Moneyline: Seminoles -130, Tigers +110
- Total: 56 points
- Prediction: Florida State 30, Clemson 29
How to Watch
- Game Date: Saturday, September 23
- Game Time: 12:00 PM ET
- TV Channel: ABC
- Location: Berkeley, California
Cincinnati Bearcats vs. No. 16 Oklahoma Sooners
Odds & Prediction
- Spread: Sooners (-13.5)
- Moneyline: Sooners -520, Bearcats +390
- Total: 57.5 points
- Prediction: Oklahoma 31, Cincinnati 28
How to Watch
- Game Date: Saturday, September 23
- Game Time: 12:00 PM ET
- TV Channel: Watch Online: FOX
- Location: Cincinnati, Ohio
No. 11 Utah Utes vs. No. 22 UCLA Bruins
Odds & Prediction
- Spread: Utes (-3.5)
- Moneyline: Utes -175, Bruins +145
- Total: 50.5 points
- Prediction: UCLA 20, Utah 19
How to Watch
- Game Date: Saturday, September 23
- Game Time: 3:30 PM ET
- TV Channel: Watch Online: FOX
- Location: Salt Lake City, Utah
No. 13 Alabama Crimson Tide vs. No. 15 Ole Miss Rebels
Odds & Prediction
- Spread: Crimson Tide (-7)
- Moneyline: Crimson Tide -258, Rebels +210
- Total: 56 points
- Prediction: Alabama 29, Ole Miss 28
How to Watch
- Game Date: Saturday, September 23
- Game Time: 3:30 PM ET
- TV Channel: CBS
- Location: Tuscaloosa, Alabama
No. 10 Oregon Ducks vs. No. 19 Colorado Buffaloes
Odds & Prediction
- Spread: Ducks (-21)
- Moneyline: Ducks -950, Buffaloes +625
- Total: 70.5 points
- Prediction: Oregon 39, Colorado 30
How to Watch
- Game Date: Saturday, September 23
- Game Time: 3:30 PM ET
- TV Channel: ABC
- Location: Eugene, Oregon
Temple Owls vs. No. 20 Miami Hurricanes
Odds & Prediction
- Spread: Hurricanes (-23)
- Moneyline: Hurricanes -2400, Owls +1200
- Total: 46 points
- Prediction: Miami (FL) 32, Temple 21
How to Watch
- Game Date: Saturday, September 23
- Game Time: 3:30 PM ET
- TV Channel: ESPN2
- Location: Philadelphia, Pennsylvania
UConn Huskies vs. No. 18 Duke Blue Devils
Odds & Prediction
- Spread: Blue Devils (-22.5)
- Moneyline: Blue Devils -2100, Huskies +1100
- Total: 45 points
- Prediction: Duke 27, UConn 16
How to Watch
- Game Date: Saturday, September 23
- Game Time: 3:30 PM ET
- TV Channel: CBS Sports Network
- Location: East Hartford, Connecticut
No. 23 Tennessee Volunteers vs. UTSA Roadrunners
Odds & Prediction
- Spread: Volunteers (-24)
- Moneyline: Volunteers -1800, Roadrunners +1000
- Total: 59.5 points
- Prediction: Tennessee 27, UTSA 21
How to Watch
- Game Date: Saturday, September 23
- Game Time: 4:00 PM ET
- TV Channel: SEC Network
- Location: Knoxville, Tennessee
No. 12 LSU Tigers vs. Arkansas Razorbacks
Odds & Prediction
- Spread: Tigers (-17.5)
- Moneyline: Tigers -1000, Razorbacks +650
- Total: 55 points
- Prediction: LSU 31, Arkansas 26
How to Watch
- Game Date: Saturday, September 23
- Game Time: 7:00 PM ET
- TV Channel: ESPN
- Location: Baton Rouge, Louisiana
No. 21 Washington State Cougars vs. No. 14 Oregon State Beavers
Odds & Prediction
- Spread: Beavers (-3)
- Moneyline: Beavers -155, Cougars +130
- Total: 57.5 points
- Prediction: Washington State 30, Oregon State 25
How to Watch
- Game Date: Saturday, September 23
- Game Time: 7:00 PM ET
- TV Channel: Watch Online: FOX
- Location: Pullman, Washington
No. 25 Florida Gators vs. Charlotte 49ers
Odds & Prediction
- Spread: Gators (-28)
- Moneyline: Gators -5000, 49ers +1800
- Total: 48.5 points
- Prediction: Florida 31, Charlotte 20
How to Watch
- Game Date: Saturday, September 23
- Game Time: 7:00 PM ET
- TV Channel: SEC Network+
- Location: Gainesville, Florida
No. 1 Georgia Bulldogs vs. UAB Blazers
Odds & Prediction
- Spread: Bulldogs (-40.5)
- Moneyline: Bulldogs , Blazers
- Total: 56 points
- Prediction: Georgia 41, UAB 17
How to Watch
- Game Date: Saturday, September 23
- Game Time: 7:30 PM ET
- TV Channel: ESPN2
- Location: Athens, Georgia
Baylor Bears vs. No. 3 Texas Longhorns
Odds & Prediction
- Spread: Longhorns (-17)
- Moneyline: Longhorns -750, Bears +525
- Total: 48.5 points
- Prediction: Texas 30, Baylor 21
How to Watch
- Game Date: Saturday, September 23
- Game Time: 7:30 PM ET
- TV Channel: ABC
- Location: Waco, Texas
No. 7 Penn State Nittany Lions vs. No. 24 Iowa Hawkeyes
Odds & Prediction
- Spread: Nittany Lions (-14)
- Moneyline: Nittany Lions -650, Hawkeyes +470
- Total: 38.5 points
- Prediction: Penn State 28, Iowa 16
How to Watch
- Game Date: Saturday, September 23
- Game Time: 7:30 PM ET
- TV Channel: CBS
- Location: University Park, Pennsylvania
No. 9 Notre Dame Fighting Irish vs. No. 6 Ohio State Buckeyes
Odds & Prediction
- Spread: Buckeyes (-3.5)
- Moneyline: Buckeyes -166, Fighting Irish +140
- Total: 55.5 points
- Prediction: Ohio State 28, Notre Dame 25
How to Watch
- Game Date: Saturday, September 23
- Game Time: 7:30 PM ET
- TV Channel: NBC
- Location: South Bend, Indiana
Pittsburgh Panthers vs. No. 17 North Carolina Tar Heels
Odds & Prediction
- Spread: Tar Heels (-7)
- Moneyline: Tar Heels -265, Panthers +215
- Total: 49.5 points
- Prediction: North Carolina 24, Pittsburgh 21
How to Watch
- Game Date: Saturday, September 23
- Game Time: 8:00 PM ET
- TV Channel: ACC Network
- Location: Pittsburgh, Pennsylvania
No. 8 Washington Huskies vs. California Golden Bears
Odds & Prediction
- Spread: Huskies (-20.5)
- Moneyline: Huskies -1100, Golden Bears +700
- Total: 57 points
- Prediction: Washington 32, Cal 23
How to Watch
- Game Date: Saturday, September 23
- Game Time: 10:30 PM ET
- TV Channel: ESPN
- Location: Seattle, Washington
Arizona State Sun Devils vs. No. 5 USC Trojans
Odds & Prediction
- Spread: Trojans (-34)
- Moneyline: Trojans , Sun Devils
- Total: 62 points
- Prediction: USC 36, Arizona State 21
How to Watch
- Game Date: Saturday, September 23
- Game Time: 10:30 PM ET
- TV Channel: Watch Online: FOX
- Location: Tempe, Arizona