College Football Top 25 Week 6 2024 Predictions, Betting Odds & TV Schedule

Updated Oct. 5, 2024 10:25 p.m. ET

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Ranked teams are on the Week 6 college football schedule in 17 games, including the No. 1 Alabama Crimson Tide taking on the Vanderbilt Commodores.

With Week 6 in college football upon us, stay on top of the latest betting odds with our preview below.

Check out the full college football schedule on FOX Sports! Or visit FOX Sports' college football hub for everything you need to make the most of this season's action.

Week 6 Betting Lines & Game Info

No. 6 Oregon Ducks vs. Michigan State Spartans

Odds & Prediction

• Spread: Ducks (-23.5)
• Moneyline: Ducks -2083, Spartans +1100
• Total: 52.5 points
• Prediction: Oregon 36, Michigan State 15

How to Watch

• Game Date: Friday, Oct. 4
• Game Time: 9:00 PM ET
• TV Channel: Watch Online: FOX
• Location: Eugene, Oregon
• Box Score

No. 25 UNLV Rebels vs. Syracuse Orange

Odds & Prediction

• Spread: Rebels (-5)
• Moneyline: Rebels -218, Orange +180
• Total: 55.5 points
• Prediction: UNLV 35, Syracuse 18

How to Watch

• Game Date: Friday, Oct. 4
• Game Time: 9:00 PM ET
• TV Channel: Watch Online: Fox Sports 1
• Location: Paradise, Nevada
• Box Score

No. 7 Penn State Nittany Lions vs. UCLA Bruins

Odds & Prediction

• Spread: Nittany Lions (-30)
• Moneyline: Nittany Lions -9091, Bruins +2500
• Total: 48 points
• Prediction: Penn State 32, UCLA 14

How to Watch

• Game Date: Saturday, Oct. 5
• Game Time: 12:00 PM ET
• TV Channel: Watch Online: FOX
• Location: University Park, Pennsylvania
• Box Score

No. 22 Louisville Cardinals vs. SMU Mustangs

Odds & Prediction

• Spread: Cardinals (-6.5)
• Moneyline: Cardinals -265, Mustangs +215
• Total: 55 points
• Prediction: Louisville 32, SMU 28

How to Watch

• Game Date: Saturday, Oct. 5
• Game Time: 12:00 PM ET
• TV Channel: ESPN
• Location: Louisville, Kentucky
• Box Score

Texas A&M Aggies vs. No. 9 Missouri Tigers

Odds & Prediction

• Spread: Aggies (-2.5)
• Moneyline: Aggies -142, Tigers +120
• Total: 47.5 points
• Prediction: Missouri 24, Texas A&M 21

How to Watch

• Game Date: Saturday, Oct. 5
• Game Time: 12:00 PM ET
• TV Channel: ABC
• Location: College Station, Texas
• Box Score

No. 5 Georgia Bulldogs vs. Auburn Tigers

Odds & Prediction

• Spread: Bulldogs (-21)
• Moneyline: Bulldogs -1639, Tigers +950
• Total: 50.5 points
• Prediction: Georgia 41, Auburn 4

How to Watch

• Game Date: Saturday, Oct. 5
• Game Time: 3:30 PM ET
• TV Channel: ABC
• Location: Athens, Georgia
• Box Score

South Carolina Gamecocks vs. No. 12 Ole Miss Rebels

Odds & Prediction

• Spread: Rebels (-10)
• Moneyline: Rebels -355, Gamecocks +280
• Total: 53 points
• Prediction: South Carolina 27, Ole Miss 24

How to Watch

• Game Date: Saturday, Oct. 5
• Game Time: 3:30 PM ET
• TV Channel: ESPN
• Location: Columbia, South Carolina
• Box Score

No. 3 Ohio State Buckeyes vs. Iowa Hawkeyes

Odds & Prediction

• Spread: Buckeyes (-17.5)
• Moneyline: Buckeyes -1205, Hawkeyes +750
• Total: 46.5 points
• Prediction: Ohio State 36, Iowa 15

How to Watch

• Game Date: Saturday, Oct. 5
• Game Time: 3:30 PM ET
• TV Channel: CBS
• Location: Columbus, Ohio
• Box Score

Northwestern Wildcats vs. No. 23 Indiana Hoosiers

Odds & Prediction

• Spread: Hoosiers (-13.5)
• Moneyline: Hoosiers -575, Wildcats +425
• Total: 40 points
• Prediction: Indiana 33, Northwestern 11

How to Watch

• Game Date: Saturday, Oct. 5
• Game Time: 3:30 PM ET
• TV Channel: BTN
• Location: Evanston, Illinois
• Box Score

Vanderbilt Commodores vs. No. 1 Alabama Crimson Tide

Odds & Prediction

• Spread: Crimson Tide (-23)
• Moneyline: Crimson Tide -2083, Commodores +1100
• Total: 54 points
• Prediction: Alabama 43, Vanderbilt 19

How to Watch

• Game Date: Saturday, Oct. 5
• Game Time: 4:15 PM ET
• TV Channel: SEC Network
• Location: Nashville, Tennessee
• Box Score

No. 21 Boise State Broncos vs. Utah State Aggies

Odds & Prediction

• Spread: Broncos (-28)
• Moneyline: Broncos -6667, Aggies +2000
• Total: 67 points
• Prediction: Boise State 59, Utah State 12

How to Watch

• Game Date: Saturday, Oct. 5
• Game Time: 7:00 PM ET
• TV Channel: Watch Online: Fox Sports 2
• Location: Boise, Idaho
• Box Score

Florida State Seminoles vs. No. 15 Clemson Tigers

Odds & Prediction

• Spread: Tigers (-17)
• Moneyline: Tigers -752, Seminoles +525
• Total: 47 points
• Prediction: Clemson 34, Florida State 19

How to Watch

• Game Date: Saturday, Oct. 5
• Game Time: 7:00 PM ET
• TV Channel: ESPN
• Location: Tallahassee, Florida
• Box Score

No. 16 Iowa State Cyclones vs. Baylor Bears

Odds & Prediction

• Spread: Cyclones (-12)
• Moneyline: Cyclones -455, Bears +350
• Total: 45.5 points
• Prediction: Iowa State 31, Baylor 13

How to Watch

• Game Date: Saturday, Oct. 5
• Game Time: 7:30 PM ET
• TV Channel: Watch Online: FOX
• Location: Ames, Iowa
• Box Score

Minnesota Golden Gophers vs. No. 11 USC Trojans

Odds & Prediction

• Spread: Trojans (-9)
• Moneyline: Trojans -305, Golden Gophers +245
• Total: 45.5 points
• Prediction: USC 27, Minnesota 18

How to Watch

• Game Date: Saturday, Oct. 5
• Game Time: 7:30 PM ET
• TV Channel: BTN
• Location: Minneapolis, Minnesota
• Box Score

Washington Huskies vs. No. 10 Michigan Wolverines

Odds & Prediction

• Spread: Huskies (-1)
• Moneyline: Huskies -120, Wolverines +100
• Total: 40 points
• Prediction: Washington 25, Michigan 17

How to Watch

• Game Date: Saturday, Oct. 5
• Game Time: 7:30 PM ET
• TV Channel: NBC
• Location: Seattle, Washington
• Box Score

Arkansas Razorbacks vs. No. 4 Tennessee Volunteers

Odds & Prediction

• Spread: Volunteers (-14.5)
• Moneyline: Volunteers -549, Razorbacks +410
• Total: 57.5 points
• Prediction: Tennessee 38, Arkansas 17

How to Watch

• Game Date: Saturday, Oct. 5
• Game Time: 7:30 PM ET
• TV Channel: ABC
• Location: Fayetteville, Arkansas
• Box Score

California Golden Bears vs. No. 8 Miami (FL) Hurricanes

Odds & Prediction

• Spread: Hurricanes (-9.5)
• Moneyline: Hurricanes -380, Golden Bears +300
• Total: 54 points
• Prediction: Miami (FL) 37, Cal 11

How to Watch

• Game Date: Saturday, Oct. 5
• Game Time: 10:30 PM ET
• TV Channel: ESPN
• Location: Berkeley, California
• Box Score

FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

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