Louisville vs. Kentucky Prediction, Odds, Picks - November 25

Updated Nov. 25, 2023 9:04 a.m. ET

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The No. 9 Louisville Cardinals (10-1) are 8-point favorites at home at L&N Federal Credit Union Stadium against the Kentucky Wildcats (6-5) on Saturday, November 25, 2023. Both teams feature solid rush defenses, with the Cardinals 13th against the run in the nation, and the Wildcats 22nd defending the rushing attack. The contest has an over/under of 49.5 points.

The Cardinals' most recent game was against the Miami Hurricanes, and they won by a score of 38-31. Facing the South Carolina Gamecocks in their last contest, the Wildcats lost 17-14.

Louisville vs. Kentucky Game Information & Odds

• When: Saturday, November 25, 2023 at 12:00 PM ET
• Location: L&N Federal Credit Union Stadium in Louisville, Kentucky
• TV: ABC
• Live boxscore on FOX Sports

Louisville vs. Kentucky Prediction

• Pick ATS: Louisville (-8)
  
• Pick OU: Over (49.5)
  
• Prediction: Louisville 34, Kentucky 18

Learn more about the Louisville Cardinals vs. the Kentucky Wildcats game on FOX Sports!

Louisville vs. Kentucky Betting Insights

• Per the spread and over/under, the implied score for the tilt is Cardinals 29, Wildcats 21.
• The Cardinals have a 75.7% chance to claim victory in this game per the moneyline's implied probability. The Wildcats hold a 28.7% implied probability.
• Louisville has put together a 6-4-1 record against the spread this season.
• Kentucky is 5-6-0 ATS this season.

Louisville vs. Kentucky: Head-to-Head

• Kentucky has a 2-0 record against Louisville in their last two matchups.
• In those matchups versus Louisville, the Wildcats have covered two times while outscoring the point total on one occasion.
• In their last two head-to-head matchups, Kentucky has tallied 78 points versus Louisville, while surrendering only 34 points.

Louisville vs. Kentucky: 2023 Stats Comparison

Louisville 2023 Key Players

Kentucky 2023 Key Players

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CFB - Kentucky Wildcats vs. Louisville Cardinals - 11/25/2023

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