Notre Dame vs. Louisville Prediction, Odds, Picks - October 7

Updated Oct. 7, 2023 3:06 p.m. ET

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The No. 25 Louisville Cardinals (5-0) and the 16th-ranked pass offense will play the No. 10 Notre Dame Fighting Irish (5-1) and the fourth-ranked passing defense on Saturday, October 7, 2023. The Fighting Irish are favored by 6.5 points in the outing. The over/under is set at 53.5.

The Fighting Irish's most recent contest was against the Duke Blue Devils, and they won by a score of 21-14. Against the NC State Wolfpack in their most recent contest, the Cardinals won 13-10.

Notre Dame vs. Louisville Game Information & Odds

• When: Saturday, October 7, 2023 at 7:30 PM ET
• Location: L&N Federal Credit Union Stadium in Louisville, Kentucky
• TV: ABC
• Live boxscore on FOX Sports

Notre Dame vs. Louisville Prediction

• Pick ATS: Notre Dame (-6.5)
  
• Pick OU: Under (53.5)
  
• Prediction: Notre Dame 30, Louisville 21

Learn more about the Notre Dame Fighting Irish vs. the Louisville Cardinals game on FOX Sports!

Notre Dame vs. Louisville Betting Insights

• Based on the spread and over/under, the implied score for the game is Fighting Irish 30, Cardinals 24.
• The Fighting Irish have a 71.9% chance to claim victory in this contest based on the moneyline's implied probability. The Cardinals have a 32.6% implied probability.
• Notre Dame has won four games against the spread this season, while failing to cover or pushing twice.
• Louisville has a record of 2-2-1 against the spread this season.

Notre Dame vs. Louisville: 2023 Stats Comparison

Notre Dame 2023 Key Players

Louisville 2023 Key Players

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CFB - Notre Dame Fighting Irish vs. Louisville Cardinals - 10/07/2023

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