Ohio State vs. Penn State Prediction, Odds, Picks - October 21

Updated Oct. 21, 2023 9:05 a.m. ET

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The No. 3 Ohio State Buckeyes (6-0) will test their 21st-ranked scoring attack against the No. 7 Penn State Nittany Lions (6-0), who have the No. 5 scoring defense in the nation, on Saturday, October 21, 2023. The Buckeyes are favored by 4.5 points in the game. The contest has a point total set at 45.5.

In their last action, the Buckeyes won versus the Purdue Boilermakers, 41-7. The Nittany Lions' last contest was versus the UMass Minutemen, and they won by a score of 63-0.

Ohio State vs. Penn State Game Information & Odds

• When: Saturday, October 21, 2023 at 12:00 PM ET
• Location: Ohio Stadium in Columbus, Ohio
• TV: FOX
• Live boxscore on FOX Sports

Ohio State vs. Penn State Prediction

• Pick ATS: Penn State (+4.5)
  
• Pick OU: Over (45.5)
  
• Prediction: Ohio State 26, Penn State 22

Learn more about the Ohio State Buckeyes vs. the Penn State Nittany Lions game on FOX Sports!

Ohio State vs. Penn State Betting Insights

• Per the spread and over/under, the implied score for the game is Buckeyes 25, Nittany Lions 20.
• The Buckeyes have a 66.0% chance to collect the win in this game based on the moneyline's implied probability. The Nittany Lions have a 38.2% implied probability.
• Ohio State has compiled a 3-2-1 record against the spread this season.
• Penn State has won all five of its games against the spread this year.

Ohio State vs. Penn State: Head-to-Head

• Ohio State has a 2-0 record against Penn State in their last two matchups.
• In those contests against Ohio State, the Nittany Lions have covered two times while going over the total on one occasion.
• Penn State has been outpaced by 22 points in its last two tilts versus Ohio State.

Ohio State vs. Penn State: 2023 Stats Comparison

Ohio State 2023 Key Players

Penn State 2023 Key Players

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CFB - Penn State Nittany Lions vs. Ohio State Buckeyes - 10/21/2023

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