Oregon vs. Colorado Prediction, Odds, Picks - September 23

Updated Sep. 23, 2023 3:05 p.m. ET

Data Skrive

Oddsmakers massively favor the No. 10 Oregon Ducks (3-0) when they host the No. 19 Colorado Buffaloes (3-0) on Saturday, September 23, 2023 in a matchup between Pac-12 rivals at Autzen Stadium. Oregon is favored by 21.5 points. A 70.5-point over/under is set for the game.

The Ducks' most recent contest was versus the Hawaii Rainbow Warriors, and they won by a score of 55-10. Last time out, the Buffaloes defeated the Colorado State Rams, with 43-35 being the final score.

Oregon vs. Colorado Game Information & Odds

When: Saturday, September 23, 2023 at 3:30 PM ET
Location: Autzen Stadium in Eugene, Oregon
TV: ABC
Live boxscore on FOX Sports

Oregon vs Colorado Betting Information updated as of September 23, 2023, 2:46 PM ET.
Favorite	Spread (Odds)	Favorite Moneyline	Underdog Moneyline	Total	Over Moneyline	Under Moneyline
Oregon	-21.5 (-109)	-926	+598	70.5	-110	-110

Oregon vs. Colorado Prediction

Pick ATS: Colorado (+21.5)
Pick OU: Under (70.5)
Prediction: Oregon 39, Colorado 30

Learn more about the Oregon Ducks vs. the Colorado Buffaloes game on FOX Sports!

Oregon vs. Colorado Betting Insights

Based on the spread and over/under, the implied score for the tilt is Ducks 46, Buffaloes 24.
The Ducks have a 90.3% chance to win this contest per the moneyline's implied probability. The Buffaloes hold a 14.3% implied probability.
Oregon has won all two of its games against the spread this season.
Colorado has a record of 2-1-0 against the spread this year.

Oregon vs. Colorado: Head-to-Head

Over their last two meetings, Oregon has tallied two wins against Colorado.
In their past two head-to-head meetings, each team has covered one time with those contests going over the point total on one occasion.
Colorado has been outscored by 62 points in its last two tilts versus Oregon.

Oregon vs. Colorado: 2023 Stats Comparison

	Oregon	Colorado
Off. Points per Game (Rank)	58.0 (3)	41.3 (22)
Def. Points per Game (Rank)	15.7 (28)	30.3 (97)
Turnovers Allowed (Rank)	0 (1)	4 (60)
Turnovers Forced (Rank)	6 (26)	7 (11)

Oregon 2023 Key Players

Name	Position	Stats
Bo Nix	QB	893 YDS (77.6%) / 8 TD / 0 INT 60 RUSH YDS / 0 RUSH TD / 20.0 RUSH YPG
Mar'Keise Irving	RB	216 YDS / 3 TD / 72.0 YPG / 8.0 YPC 12 REC / 95 REC YDS / 0 REC TD / 31.7 REC YPG
Jordan James	RB	155 YDS / 5 TD / 51.7 YPG / 7.4 YPC
Troy Franklin	WR	17 REC / 292 YDS / 3 TD / 97.3 YPG
Tysheem Johnson	DB	15 TKL / 2.0 TFL / 1.0 SACK
Jeffrey Bassa	LB	15 TKL / 1.0 TFL / 1 INT / 1 PD
Khyree Jackson	DB	9 TKL / 1.0 TFL / 2 INT / 2 PD
Bryce Boettcher	N/A	10 TKL / 1.0 TFL / 1.0 SACK

Colorado 2023 Key Players

Name	Position	Stats
Shedeur Sanders	QB	1,251 YDS (78.7%) / 10 TD / 1 INT -59 RUSH YDS / 1 RUSH TD / -19.7 RUSH YPG
Dylan Edwards	RB	136 YDS / 1 TD / 45.3 YPG / 5.4 YPC 14 REC / 160 REC YDS / 3 REC TD / 53.3 REC YPG
Xavier Weaver	WR	25 REC / 386 YDS / 2 TD / 128.7 YPG
Jimmy Horn Jr.	WR	26 REC / 247 YDS / 2 TD / 82.3 YPG
Trevor Woods	S	17 TKL / 0.0 TFL / 2 INT / 3 PD
Shilo Sanders	S	17 TKL / 0.0 TFL / 1 INT / 1 PD
Marvin Ham II	LB	20 TKL / 1.0 TFL / 1.0 SACK
Jordan Domineck	OLB	12 TKL / 4.0 TFL / 1.0 SACK