USC vs. Colorado Prediction, Odds, Picks - September 30

Updated Sep. 29, 2023 9:05 a.m. ET

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The No. 8 USC Trojans (4-0), who have college football's third-ranked passing offense, play the Colorado Buffaloes (3-1) and their fifth-ranked passing attack on Saturday, September 30, 2023. The Trojans are heavy, 21.5-point favorites. The total is 73.5 points for this game.

The Trojans beat the Arizona State Sun Devils, 42-28, in their last contest. The Buffaloes lost to the Oregon Ducks, 42-6, in their most recent game.

USC vs. Colorado Game Information & Odds

• When: Saturday, September 30, 2023 at 12:00 PM ET
• Location: Folsom Field in Boulder, Colorado
• TV: FOX
• Live boxscore on FOX Sports

USC vs. Colorado Prediction

• Pick ATS: Colorado (+21.5)
  
• Pick OU: Under (73.5)
  
• Prediction: USC 38, Colorado 32

Learn more about the USC Trojans vs. the Colorado Buffaloes game on FOX Sports!

USC vs. Colorado Betting Insights

• Based on the spread and over/under, the implied score for the game is Trojans 48, Buffaloes 26.
• The Trojans have a 93.4% chance to win this game based on the moneyline's implied probability. The Buffaloes have an 11.0% implied probability.
• USC has won two games against the spread this season.
• Colorado has won two games against the spread this season.

USC vs. Colorado: Head-to-Head

• In their last two head-to-head meetings, USC has taken down Colorado two times.
• In those matchups versus Colorado, the Trojans have covered two times while outpacing the total on one occasion.
• Over their last two head-to-head contests, USC has put up 92 points, while Colorado has compiled 31.

USC vs. Colorado: 2023 Stats Comparison

USC 2023 Key Players

Colorado 2023 Key Players

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CFB - USC Trojans vs. Colorado Buffaloes - 09/30/2023

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