Astros vs. Blue Jays Prediction, Odds, Picks - April 21

Jose Carlos Altuve and the Houston Astros take on Bo Joseph Bichette and the Toronto Blue Jays on Monday at 8:10 p.m. ET, in the first of a three-game series at Daikin Park. The Astros are favored in this one, at -139, while the underdog Blue Jays have +118 odds to win. Houston (-1.5) is favored on the run line. The total is 7.5 runs for the matchup (with -104 odds on the over and -116 odds on the under).

Take a look at everything you need from a betting perspective on the Astros-Blue Jays game, regarding the run line, moneyline and total, plus expert picks.

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Astros vs. Blue Jays Game Information & Odds

• When: Monday, April 21, 2025 at 8:10 p.m. ET
• Where: Daikin Park in Houston, Texas
• How to watch on TV: SCHN and SN1

Astros vs. Blue Jays Prediction

• Score Prediction: Astros 4, Blue Jays 3
• Total Prediction: Under 7.5 runs
• Win Probabilities: Astros 57%, Blue Jays 43%

Astros vs. Blue Jays Betting Insights

• This season, the Astros have been favored 13 times and won six, or 46.2%, of those games.
• This season Houston has won three of its six games when favored by at least -139 on the moneyline.
• The implied probability of a win from the Astros, based on the moneyline, is 58.2%.
• The Blue Jays have been victorious in seven, or 46.7%, of the 15 contests they have been chosen as underdogs in this season.
• Toronto has been listed as an underdog of +118 or more on two occasions this season and split those games.
• The moneyline set for this matchup implies the Blue Jays have a 45.9% chance of coming away with a victory in the contest.

Astros Recent Betting Performance

• The Astros went 4-4 over the eight games they were moneyline favorites in their last 10 matchups.
• Over their last 10 outings, the Astros and their opponents combined to hit the over five times (all 10 of the games had set totals).
• The Astros' ATS record is 6-4-0 over their past 10 games.

Astros Recent Stats

Astros Player Insights

• Jeremy Pena leads the Astros with three home runs on the year. He's also hitting .224 with seven RBI.
• Pena is 73rd in homers and 157th in RBI among all hitters in the majors.
• Pena carries an 11-game hitting streak into this matchup. During his last 10 games he is batting .297 with three doubles, a home run, four walks and five RBI.
• Altuve's three home runs pace his team.
• Altuve is 73rd in home runs and 157th in RBI on the season.
• Isaac Paredes has put up a team-high three home runs and 11 runs batted in.
• Jake Meyers' .305 batting average paces his team.

Astros Team Props

Blue Jays Recent Betting Performance

• In nine games as underdogs over the last 10 matchups, the Blue Jays have a record of 4-5.
• In their last 10 games with a total, the Blue Jays and their opponents have failed to hit the over four times.
• The Blue Jays are 7-3-0 ATS over their last 10 games.

Blue Jays Recent Stats

Blue Jays Player Insights

• Vladimir Guerrero Jr. has six doubles, a home run and 14 walks while batting .305.
• Among all hitters in MLB, Guerrero's home run total ranks 169th and his RBI tally ranks 84th.
• Bichette has racked up 13 runs batted in to lead his team.
• Bichette ranks 269th overall in home runs and 38th in RBI this season.
• Andres Gimenez leads the Blue Jays with three long balls.
• George Springer paces the Blue Jays with a team-high batting average of .344.

Blue Jays Team Props

Astros' Christian Walker crushes a two-run homer to tie the game against Padres

Houston Astros' Christian Walker crushed a two-run homer that tied the game against the San Diego Padres.

FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

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