Astros vs. Cardinals Prediction, Odds, Picks - April 15

Isaac Paredes and the Houston Astros take on Brendan Donovan and the St. Louis Cardinals on Tuesday at 7:45 p.m. ET, in the second of a three-game series at Busch Stadium. The favored Astros have -129 moneyline odds against the underdog Cardinals, who are listed at +110. Houston is favored on the run line (-1.5). A 7.5-run total is listed in the matchup.

Here's everything you need to know from a betting perspective on the Astros-Cardinals game, regarding the run line, moneyline and total, plus expert picks.

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Astros vs. Cardinals Game Information & Odds

• When: Tuesday, April 15, 2025 at 7:45 p.m. ET
• Where: Busch Stadium in St. Louis, Missouri
• How to watch on TV: FDSMWX and SCHN

Astros vs. Cardinals Prediction

• Score Prediction: Cardinals 6, Astros 5
• Total Prediction: Over 7.5 runs
• Win Probabilities: Astros 51%, Cardinals 49%

Astros vs. Cardinals Betting Insights

• This season, the Astros have been favored 10 times and won four of those games.
• Houston is 2-4 this season when entering a game favored by -129 or more on the moneyline.
• The Astros have a 56.3% chance to win this game based on the implied probability of the moneyline.
• The Cardinals have won in seven, or 63.6%, of the 11 contests they have been named as odds-on underdogs this year.
• St. Louis has a win-loss record of 2-1 when favored by +110 or worse by bookmakers this year.
• The moneyline set for this matchup implies the Cardinals have a 47.6% chance of walking away with the win.

Astros Recent Betting Performance

• The Astros played as the moneyline favorite in five of their last 10 games, and went 2-3 in those matchups.
• Over their last 10 matchups, the Astros and their opponents combined to hit the over on the total five times (all 10 games had set totals).
• The Astros have gone 6-4-0 against the spread over their past 10 games.

Astros Recent Stats

Astros Player Insights

• Jose Altuve's .288 average and three homers both put him atop the Astros leaderboard this season.
• In all of MLB, Altuve is 44th in home runs and 104th in RBI.
• Paredes has hit three home runs with nine RBI. Both lead his team.
• Among all MLB hitters, Paredes is 44th in homers and 58th in RBI.
• Jeremy Pena has launched a team-best three home runs.
• Pena has at least one base hit in six games in a row. During his last 10 games he is batting .256 with a double, two home runs, three walks and six RBI.
• Yordan Alvarez has put up nine runs batted in to pace his team.

Astros Team Props

Cardinals Recent Betting Performance

• The Cardinals have played as underdogs in eight of their past 10 games and won four of those contests.
• The Cardinals and their opponents have combined to hit the over five times in their last 10 games with a total.
• The Cardinals have a record of 5-5-0 ATS over their last 10 games.

Cardinals Recent Stats

Cardinals Player Insights

• Nolan Arenado has six doubles, two home runs and nine walks while batting .316.
• In all of MLB, Arenado is 83rd in home runs and 58th in RBI.
• Donovan has a club-leading 11 runs batted in and .391 batting average.
• Among all major league batters, Donovan is 83rd in home runs and 27th in RBI.
• Lars Nootbaar is batting .279 with two doubles, two home runs and 12 walks.
• Victor Scott II has two doubles, a triple, a home run and six walks while batting .259.

Cardinals Team Props

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Check out the best moments between the Los Angeles Angels and the Houston Astros.

FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

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