Astros vs. Royals Prediction, Odds, Picks - September 22

Updated Sep. 22, 2023 8:07 p.m. ET

Data Skrive

The Houston Astros will send a hot-hitting Jose Altuve to the plate against the Kansas City Royals and Bobby Witt Jr., who has been on a tear in recent games, when the squads take the field on Friday at 8:10 PM ET. The Astros are favored in this one, at -232, while the underdog Royals have +189 odds to win. Houston (-1.5) is favored on the run line. The contest's over/under has been listed at 8.5 runs.

The scheduled starters are Framber Valdez (12-10) for the Houston Astros, and Cole Ragans (6-4) for the Kansas City Royals.

Here's everything you need from a betting perspective on the Astros-Royals game, from the point spread, moneyline, Over/Under and expert picks.

Astros vs. Royals Game Information & Odds

When: Friday, September 22, 2023 at 8:10 PM ET
Where: Minute Maid Park in Houston, Texas
How to Watch on TV: SportsNet SW

Favorite	Favorite Moneyline	Underdog Moneyline	Total	Over Total Odds	Under Total Odds	Run Line	Favorite Run Line Odds	Underdog Run Line Odds
Astros	-232	+189	8.5	-109	-110	-1.5	-105	-115

Astros vs. Royals Prediction

Score Prediction: Astros 5, Royals 4
Total Prediction: Over 8.5 runs
Win Probabilities: Astros 59%, Royals 41%

Astros vs. Royals Betting Insights

The Astros have been favorites in 112 games this season and won 58 (51.8%) of those contests.
Houston has a record of 13-4 in games when oddsmakers favor them by at least -232 on the moneyline.
The oddsmakers' moneyline implies a 69.9% chance of a victory for the Astros.
The Royals have been victorious in 43, or 33.1%, of the 130 contests they have been chosen as underdogs in this season.
This year, Kansas City has won six of 27 games when listed as at least +189 or worse on the moneyline.
The moneyline set for this matchup implies the Royals have a 34.6% chance of walking away with the win.

Astros Recent Betting Performance

The Astros went 3-6 over the nine games they were favored on the moneyline in their last 10 matchups.
In their last 10 matchups (all 10 of them had set totals), the Astros and their opponents combined to go over the run total four times.
The Astros' ATS record is 4-6-0 over their past 10 games.

Astros Recent Stats

Stat	Avg/Total
Record	4-6
Runs Per Game	5.1
HR	14
ERA	4.30
K/9	9

Astros Player Insights

Kyle Tucker's 28 long balls and 108 RBI both lead the Astros, on top of his team-high .282 average.
Among all MLB hitters, Tucker is 18th in batting average, 16th in on-base percentage, and 16th in slugging.
Alex Bregman is hitting .266 with 27 doubles, three triples, 24 home runs and 87 walks.
Bregman ranks 48th in homers and 14th in RBI in the bigs.
Yordan Alvarez has collected a team-best 28 home runs.
Altuve is hitting .312 with 20 doubles, two triples, 17 home runs and 42 walks.

Learn more about this Astros vs. Royals matchup on Fox Sports.

Royals Recent Betting Performance

The Royals have played as underdogs in 10 of their past 10 games and won six of those contests.
The Royals and their opponents have combined to hit the over three times in their last 10 games with a total.
The Royals have won six of their last 10 games against the spread.

Royals Recent Stats

Stat	Avg/Total
Record	7-3
Runs Per Game	5.6
HR	9
ERA	5.01
K/9	7.9

Royals Player Insights

Witt Jr. paces the Royals in home runs (29), runs batted in (91) and has posted a team-high batting average of .278.
Among all hitters in the majors, Witt Jr. ranks 22nd in homers and 29th in RBI.
Witt Jr. carries a three-game hitting streak into this matchup. In his last five games he is batting .286 with a double, a walk and two RBI.
MJ Melendez is hitting .234 with 28 doubles, five triples, 15 home runs and 59 walks.
Melendez ranks 139th in homers and 146th in RBI among all hitters in MLB.
Maikel Garcia is batting .275 with 20 doubles, four triples, four home runs and 35 walks.
Edward Olivares has 21 doubles, four triples, 10 home runs and 21 walks while hitting .264.