Brewers vs. Cardinals Prediction, Odds, Picks - September 21

Updated Sep. 21, 2023 1:06 p.m. ET

Data Skrive

Christian Yelich and the Milwaukee Brewers will meet Nolan Arenado and the St. Louis Cardinals on Thursday at Busch Stadium, at 1:15 PM ET. The Cardinals are listed as -109 moneyline underdogs for this matchup with the favored Brewers (-111). Milwaukee is favored on the run line (-1.5). An 8.5-run over/under is set in the matchup.

The Milwaukee Brewers will hand the ball to Wade Miley (8-4, 3.38 ERA), who is looking for win No. 9 on the season, and the Cardinals will turn to Miles Mikolas (7-12, 4.84 ERA).

Check out everything you need from a betting perspective on the Brewers-Cardinals game, from the point spread, moneyline, Over/Under and expert picks.

Brewers vs. Cardinals Game Information & Odds

When: Thursday, September 21, 2023 at 1:15 PM ET
Where: Busch Stadium in St. Louis, Missouri
How to Watch on TV: MLB Network

Favorite	Favorite Moneyline	Underdog Moneyline	Total	Over Total Odds	Under Total Odds	Run Line	Favorite Run Line Odds	Underdog Run Line Odds
Brewers	-111	-109	8.5	-116	-104	-1.5	+153	-186

Brewers vs. Cardinals Prediction

Score Prediction: Brewers 6, Cardinals 5
Total Prediction: Over 8.5 runs
Win Probabilities: Brewers 52%, Cardinals 48%

Brewers vs. Cardinals Betting Insights

This season, the Brewers have won 47 out of the 79 games, or 59.5%, in which they've been favored.
Milwaukee has a record of 47-32, a 59.5% win rate, when favored by -111 or more by oddsmakers this season.
The implied probability of a win from the Brewers, based on the moneyline, is 52.6%.
The Cardinals have been underdogs in 75 games this season and have come away with the win 32 times (42.7%) in those contests.
St. Louis has a mark of 31-42 in contests where sportsbooks favor it by -109 or worse on the moneyline.
The Cardinals have an implied victory probability of 52.2% according to the moneyline set by oddsmakers for this matchup.

Brewers Recent Betting Performance

The Brewers were favored on the moneyline in nine of their last 10 games, and they finished 6-3 in those matchups.
In their last 10 matchups -- all had a set run total -- the Brewers and their opponents combined to go over the total four times.
The Brewers' record against the spread is 7-3-0 over their past 10 games.

Brewers Recent Stats

Stat	Avg/Total
Record	7-3
Runs Per Game	4.9
HR	11
ERA	1.98
K/9	8

Brewers Player Insights

Yelich is batting .272 with 31 doubles, two triples, 17 home runs and 72 walks.
In all of the majors, Yelich is 113th in homers and 74th in RBI.
William Contreras' .284 batting average leads his team.
Contreras is 113th in home runs and 66th in RBI among all MLB batters this year.
Contreras has eight straight games with at least one hit. In his last 10 games he is batting .333 with two doubles, two home runs, seven walks and five RBI.
Carlos Santana is batting .231 with 30 doubles, 21 home runs and 62 walks.
Willy Adames has hit 24 home runs with 78 runs batted in. Both pace his team.

Learn more about this Brewers vs. Cardinals matchup on Fox Sports.

Cardinals Recent Betting Performance

The Cardinals have played as underdogs in 10 of their past 10 games and won four of those contests.
In their last 10 games with a total, the Cardinals and their opponents have failed to hit the over five times.
The Cardinals have won five of their last 10 games against the spread.

Cardinals Recent Stats

Stat	Avg/Total
Record	4-6
Runs Per Game	2.9
HR	8
ERA	5.22
K/9	6.8

Cardinals Player Insights

The Cardinals are led in runs batted in by Arenado with a mark of 93, he also leads the team in hitting, posting an average of .269.
In all of the big leagues, Arenado is 34th in homers and 21st in RBI.
Paul Goldschmidt's .269 batting average paces his team.
Among all major league hitters, Goldschmidt is 40th in homers and 47th in RBI.
Lars Nootbaar has 23 doubles, a triple, 13 home runs and 67 walks while batting .268.
Willson Contreras is hitting .264 with 27 doubles, 20 home runs and 51 walks.