Cardinals vs. Guardians Prediction, Odds, Picks - September 20

Published Sep. 19, 2024 9:00 p.m. ET

Data Skrive

Alec Burleson and Jose Ramirez will be among the stars on display when the St. Louis Cardinals face the Cleveland Guardians on Friday at 8:15 p.m. ET, at Busch Stadium. The Cardinals are -114 moneyline favorites for this matchup with the Guardians (-105). Cleveland is favored on the run line (-1.5 with +149 odds). An 8-run over/under has been set for this contest.

Here is everything you need to know from a betting perspective on the Cardinals-Guardians game, regarding the run line, moneyline and total, plus expert picks.

Twins vs. Guardians Highlights | MLB on FOX

Check out the best moments from the Minnesota Twins vs. Cleveland Guardians on Thursday, September 19th.

Cardinals vs. Guardians Game Information & Odds

When: Friday, September 20, 2024 at 8:15 p.m. ET
Where: Busch Stadium in St. Louis, Missouri
How to Watch on TV: BSMW

Favorite	Favorite Moneyline	Underdog Moneyline	Total	Over Total Odds	Under Total Odds	Run Line	Favorite Run Line Odds	Underdog Run Line Odds
Cardinals	-114	-105	8	-115	-105	-1.5	-179	+149

Cardinals vs. Guardians Prediction

Score Prediction: Cardinals 5, Guardians 4
Total Prediction: Over 8 runs
Win Probabilities: Cardinals 51%, Guardians 49%

Cardinals vs. Guardians Betting Insights

This season, the Cardinals have been favored 71 times and won 37, or 52.1%, of those games.
St. Louis has a record of 33-33 in games when sportsbooks favor them by at least -114 on the moneyline.
Sportsbooks have implied with the moneyline set for this matchup that the Cardinals have a 53.3% chance to win.
The Guardians have been underdogs in 56 games this season and have come away with the win 26 times (46.4%) in those contests.
This season, Cleveland has been victorious 21 times in 50 chances when named as an underdog of at least -105 or longer on the moneyline.
The Guardians have an implied victory probability of 51.2% according to the moneyline set for this matchup.

Cardinals Recent Betting Performance

The Cardinals were favored on the moneyline in five of their last 10 games, and they went 4-1 in those matchups.
In their last 10 matchups, the Cardinals and their opponents combined to go over the run total three times (all 10 of the games had set totals).
The Cardinals' ATS record is 6-4-0 over their past 10 games.

Cardinals Recent Stats

Stat	Avg/Total
Record	5-5
Runs Per Game	3.6
HR	9
ERA	3.03
K/9	9.9

Cardinals Player Insights

Not only does Burleson lead the Cardinals in hitting with his .271 average, he also is their foremost power hitter with 21 home runs and 73 RBI.
Including all MLB hitters, Burleson is 34th in batting average, 90th in on-base percentage, and 66th in slugging.
Brendan Donovan is batting .271 to pace his team.
Donovan is 145th in homers and 74th in RBI among all major league batters this year.
Donovan enters this matchup looking for his fourth game in a row with a hit. During his last five outings he is batting .278 with two doubles, a home run, three walks and three RBI.
Nolan Arenado is batting .269 with 22 doubles, 16 home runs and 43 walks.
Masyn Winn's .271 batting average leads his team.
Winn is riding a three-game hitting streak into this one. In his last five games he is hitting .227 with a double, a home run, a walk and an RBI.

Learn more about this Cardinals vs. Guardians matchup on Fox Sports.

Guardians Recent Betting Performance

Over the past 10 games, the Guardians have been underdogs twice and won both contests.
When it comes to hitting the over, the Guardians and their opponents are 2-8-0 in their last 10 games with a total.
The Guardians have won six of their last 10 games against the spread.

Guardians Recent Stats

Stat	Avg/Total
Record	7-3
Runs Per Game	3.5
HR	9
ERA	1.76
K/9	10.6

Guardians Player Insights

Ramirez leads the Guardians in home runs (35) and runs batted in (107).
Ramirez's home run total puts him eighth in the big leagues, and he is sixth in RBI.
Josh Naylor is batting .244 with 26 doubles, 31 home runs and 55 walks.
Naylor ranks 15th overall in homers and seventh in RBI this year.
Andres Gimenez is batting .253 with 21 doubles, a triple, eight home runs and 26 walks.
Lane Thomas has 26 doubles, three triples, 13 home runs and 43 walks while hitting .241.