Cardinals vs. Guardians Prediction, Odds, Picks - September 20

Updated Sep. 20, 2024 8:00 p.m. ET

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Brendan Donovan and the St. Louis Cardinals will meet Jose Ramirez and the Cleveland Guardians on Friday at Busch Stadium, at 8:15 p.m. ET. The Guardians are -102 moneyline underdogs for this matchup against the favored Cardinals (-117). St. Louis (-1.5) is the favorite on the run line. The game's over/under is set at 8 runs.

Check out everything you need to know from a betting perspective on the Cardinals-Guardians game, regarding the run line, moneyline and total, plus expert picks.

Pirates vs. Cardinals Highlights | MLB on FOX

Check out the top moments between the Pittsburgh Pirates and the St. Louis Cardinals.

Cardinals vs. Guardians Game Information & Odds

• When: Friday, September 20, 2024 at 8:15 p.m. ET
• Where: Busch Stadium in St. Louis, Missouri
• How to Watch on TV: BSMW

Cardinals vs. Guardians Prediction

• Score Prediction: Cardinals 5, Guardians 4
• Total Prediction: Over 8 runs
• Win Probabilities: Cardinals 51%, Guardians 49%

Cardinals vs. Guardians Betting Insights

• The Cardinals have entered the game as favorites 72 times this season and won 37, or 51.4%, of those games.
• St. Louis has entered 59 games this season favored by -117 or more and is 30-29 in those contests.
• The bookmakers' moneyline implies a 53.9% chance of a victory for the Cardinals.
• The Guardians have been underdogs in 56 games this season and have come away with the win 26 times (46.4%) in those contests.
• This season, Cleveland has been victorious 20 times in 49 chances when named as an underdog of at least -102 or longer on the moneyline.
• The Guardians have an implied victory probability of 50.5% according to the moneyline set for this matchup.

FINAL

CLE 5 · STL 1

MLB

RUN LINE

TO WIN

TOTAL

Cleveland Guardians

CLE

-1.5

-102

O 8

St. Louis Cardinals

STL

+1.5

-118

U 8

Cardinals Recent Betting Performance

• The Cardinals have a 4-2 record from the six games they were favored on the moneyline over their last 10 matchups.
• In their last 10 outings (all had set totals), the Cardinals combined with their opponents to hit the over on the total two times.
• The Cardinals have put together a 6-4-0 record against the spread over their past 10 games.

Cardinals Recent Stats

Cardinals Player Insights

• Donovan's .277 average leads the Cardinals this year. His resume also includes 13 homers and driven in 68 RBI.
• Donovan's home runs place him 145th in the majors, and he ranks 70th in RBI.
• Donovan has collected a hit in four straight games. In his last five games he is hitting .444 with three doubles, a home run, three walks and five RBI.
• Alec Burleson has shown off his power as he paces his team with 21 home runs and 73 RBI.
• Burleson ranks 55th in home runs and 48th in RBI in the major leagues.
• Nolan Arenado is hitting .268 with 22 doubles, 16 home runs and 44 walks.
• Masyn Winn has 27 doubles, four triples, 14 home runs and 39 walks while batting .269.

Cardinals Team Props

Learn more about this Cardinals vs. Guardians matchup on Fox Sports.

Guardians Recent Betting Performance

• The Guardians have been underdogs twice in the last 10 games and won both contests.
• When it comes to hitting the over, the Guardians and their opponents are 2-8-0 in their last 10 games with a total.
• The Guardians have six wins against the spread in their last 10 chances.

Guardians Recent Stats

Guardians Player Insights

• Ramirez has posted a team-leading 35 home runs and has driven in 107 runs.
• In all of the majors, Ramirez ranks eighth in home runs and sixth in RBI.
• Josh Naylor is batting .244 with 26 doubles, 31 home runs and 55 walks.
• Naylor ranks 15th in home runs and seventh in RBI among all major league hitters this year.
• Andres Gimenez has 21 doubles, a triple, eight home runs and 26 walks while hitting .253.
• Lane Thomas is hitting .241 with 26 doubles, three triples, 13 home runs and 43 walks.

Guardians Team Props

Pirates vs. Cardinals Highlights | MLB on FOX

Check out the top moments between the Pittsburgh Pirates and the St. Louis Cardinals.

FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

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