Cardinals vs. Guardians Prediction, Odds, Picks - September 21

Updated Sep. 21, 2024 7:00 p.m. ET

share

facebookxredditlink

Brendan Donovan and the St. Louis Cardinals take on Lane Thomas and the Cleveland Guardians on Saturday at 7:15 p.m. ET. The Cardinals are the favorite in this one, at -117, while the underdog Guardians have -102 odds to upset. St. Louis is a 1.5-run favorite (at +178 odds). The over/under is 8 runs for this matchup (with -115 odds to go over and -105 odds to go under).

Take a look at everything you need to know from a betting perspective on the Cardinals-Guardians game, regarding the run line, moneyline and total, plus expert picks.

Guardians vs. Cardinals Highlights | MLB on FOX

Check out the top moments between the Cleveland Guardians and the St. Louis Cardinals.

Cardinals vs. Guardians Game Information & Odds

• When: Saturday, September 21, 2024 at 7:15 p.m. ET
• Where: Busch Stadium in St. Louis, Missouri
• How to Watch on TV: BSGL

Cardinals vs. Guardians Prediction

• Score Prediction: Cardinals 5, Guardians 4
• Total Prediction: Over 8 runs
• Win Probabilities: Cardinals 50%, Guardians 50%

Cardinals vs. Guardians Betting Insights

• The Cardinals have been favorites in 73 games this season and won 37 (50.7%) of those contests.
• This season St. Louis has won 30 of its 60 games, or 50%, when favored by at least -117 on the moneyline.
• The moneyline for this contest implies a 53.9% chance of a victory for the Cardinals.
• The Guardians have come away with 27 wins in the 57 contests they have been listed as the underdogs in this season.
• This year, Cleveland has won 20 of 49 games when listed as at least -102 or worse on the moneyline.
• The moneyline set for this matchup implies the Guardians have a 50.5% chance of coming away with a victory in the contest.

FINAL

CLE 5 · STL 6

MLB

RUN LINE

TO WIN

TOTAL

Cleveland Guardians

CLE

-1.5

-131

O 7.5

St. Louis Cardinals

STL

+1.5

+110

U 7.5

Cardinals Recent Betting Performance

• The Cardinals played as the moneyline favorite in six of their last 10 games, and they went 4-2 in those matchups.
• In their last 10 outings, the Cardinals and their opponents combined to go over the run total two times (all 10 games had set totals).
• The Cardinals' record against the spread is 6-4-0 over their past 10 games.

Cardinals Recent Stats

Cardinals Player Insights

• The Cardinals best hitter so far this season is Donovan, who's hitting at a team-leading .275 rate along with 13 homers and 68 RBI.
• Donovan ranks 145th in home runs and 71st in RBI among all hitters in MLB.
• Alec Burleson has shown off his power as he paces his team with 21 home runs and 73 RBI.
• Burleson is 56th in homers and 49th in RBI among all hitters in baseball.
• Nolan Arenado is batting .268 with 22 doubles, 16 home runs and 44 walks.
• Masyn Winn is hitting .267 with 27 doubles, four triples, 14 home runs and 39 walks.

Cardinals Team Props

Learn more about this Cardinals vs. Guardians matchup on Fox Sports.

Guardians Recent Betting Performance

• In three games as an underdog over the last 10 matchups, Cleveland has a perfect record of 3-0.
• In their last 10 games with a total, the Guardians and their opponents have failed to hit the over eight times.
• The Guardians are 6-4-0 ATS over their last 10 games.

Guardians Recent Stats

Guardians Player Insights

• Jose Ramirez paces the Guardians with 36 home runs and runs batted in, driving in 109.
• In all of the majors, Ramirez is eighth in home runs and fourth in RBI.
• Josh Naylor is batting .243 with 26 doubles, 31 home runs and 56 walks.
• Naylor is 15th overall in home runs and seventh in RBI this season.
• Andres Gimenez is hitting .253 with 21 doubles, a triple, nine home runs and 26 walks.
• Thomas is hitting .241 with 26 doubles, three triples, 14 home runs and 43 walks.

Guardians Team Props

Guardians vs. Cardinals Highlights | MLB on FOX

Check out the top moments between the Cleveland Guardians and the St. Louis Cardinals.

FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

Want great stories delivered right to your inbox? Create or log in to your FOX Sports account, follow leagues, teams and players to receive a personalized newsletter daily.

FOLLOW Follow your favorites to personalize your FOX Sports experience

St. Louis Cardinals

Cleveland Guardians

share

in this topic

Major League Baseball

St. Louis Cardinals

Cleveland Guardians

MLB - Cleveland Guardians vs. St. Louis Cardinals - 09/21/2024

Gambling