Cardinals vs. Guardians Prediction, Odds, Picks - September 21

Updated Sep. 21, 2024 5:02 a.m. ET

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Miles Mikolas is set to start for the St. Louis Cardinals on Saturday against Lane Thomas and the Cleveland Guardians. First pitch is at 7:15 p.m. ET at Busch Stadium. The Cardinals are favored in this one, at -117, while the underdog Guardians have -102 odds to win. St. Louis is favored on the run line (-1.5 with +178 odds). An 8-run total is set for this matchup.

Check out everything you need from a betting perspective on the Cardinals-Guardians game, regarding the run line, moneyline and total, plus expert picks.

Guardians vs. Cardinals Highlights | MLB on FOX

Check out the top moments between the Cleveland Guardians and the St. Louis Cardinals.

Cardinals vs. Guardians Game Information & Odds

• When: Saturday, September 21, 2024 at 7:15 p.m. ET
• Where: Busch Stadium in St. Louis, Missouri
• How to Watch on TV: BSGL

Cardinals vs. Guardians Prediction

• Score Prediction: Cardinals 5, Guardians 4
• Total Prediction: Over 8 runs
• Win Probabilities: Cardinals 50%, Guardians 50%

Cardinals vs. Guardians Betting Insights

• This season, the Cardinals have won 37 out of the 73 games, or 50.7%, in which they've been favored.
• St. Louis has a record of 30-30 in games when sportsbooks favor them by at least -117 on the moneyline.
• Oddsmakers have implied with the moneyline set for this matchup that the Cardinals have a 53.9% chance to win.
• The Guardians have been victorious in 27, or 47.4%, of the 57 contests they have been chosen as underdogs in this season.
• This year, Cleveland has won 20 of 49 games when listed as at least -102 or worse on the moneyline.
• The Guardians have an implied victory probability of 50.5% according to the moneyline set by sportsbooks for this matchup.

Sat 11:15 PM

BSGL

MLB

RUN LINE

TO WIN

TOTAL

Cleveland Guardians

CLE

-1.5

-135

O 8

St. Louis Cardinals

STL

+1.5

+115

U 8

Cardinals Recent Betting Performance

• The Cardinals played as the moneyline favorite in six of their last 10 games, and they went 4-2 in those matchups.
• Over their last 10 outings (all had set totals), the Cardinals combined with their opponents to go over the total two times.
• The Cardinals' ATS record is 6-4-0 over their past 10 games.

Cardinals Recent Stats

Cardinals Player Insights

• Brendan Donovan is the Cardinals best hitter so far this season, hitting at a team-leading .275 rate along with 13 homers and 68 RBI.
• Including all MLB hitters, Donovan ranks 31st in batting average, 39th in on-base percentage, and 80th in slugging.
• Alec Burleson has shown his power as he leads his team with 21 home runs and 73 RBI.
• Including all MLB hitters, Burleson ranks 56th in homers and 48th in RBI.
• Nolan Arenado has 22 doubles, 16 home runs and 44 walks while hitting .268.
• Masyn Winn has 27 doubles, four triples, 14 home runs and 39 walks while hitting .267.

Cardinals Team Props

Learn more about this Cardinals vs. Guardians matchup on Fox Sports.

Guardians Recent Betting Performance

• In three games as an underdog over the last 10 matchups, Cleveland has a perfect record of 3-0.
• In their last 10 games with a total, the Guardians and their opponents are 2-8-0 when it comes to hitting the over.
• The Guardians have won six of their last 10 games against the spread.

Guardians Recent Stats

Guardians Player Insights

• Jose Ramirez has posted a team-leading 36 home runs and has driven in 109 runs.
• In all of the big leagues, Ramirez ranks eighth in home runs and fourth in RBI.
• Josh Naylor has 26 doubles, 31 home runs and 56 walks while hitting .243.
• Naylor is 15th in homers and seventh in RBI among all batters in MLB.
• Andres Gimenez is batting .253 with 21 doubles, a triple, nine home runs and 26 walks.
• Thomas is batting .241 with 26 doubles, three triples, 14 home runs and 43 walks.

Guardians Team Props

Guardians vs. Cardinals Highlights | MLB on FOX

Check out the top moments between the Cleveland Guardians and the St. Louis Cardinals.

FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

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