Cardinals vs. Guardians Prediction, Odds, Picks - September 22

Updated Sep. 22, 2024 2:00 p.m. ET

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Brendan Donovan and the St. Louis Cardinals square off against Josh Naylor and the Cleveland Guardians on Sunday at 2:15 p.m. ET, in the final of a three-game series at Busch Stadium. The Cardinals are favored in this one, at -123, while the underdog Guardians have +103 odds to upset. St. Louis is the run-line favorite (-1.5). A 7.5-run over/under is set for the contest.

Check out everything you need from a betting perspective on the Cardinals-Guardians game, regarding the run line, moneyline and total, plus expert picks.

Guardians vs. Cardinals Highlights | MLB on FOX

Check out the top moments between the Cleveland Guardians and the St. Louis Cardinals.

Cardinals vs. Guardians Game Information & Odds

• When: Sunday, September 22, 2024 at 2:15 p.m. ET
• Where: Busch Stadium in St. Louis, Missouri
• How to Watch on TV: BSGL

Cardinals vs. Guardians Prediction

• Score Prediction: Cardinals 5, Guardians 4
• Total Prediction: Over 7.5 runs
• Win Probabilities: Cardinals 51%, Guardians 49%

Cardinals vs. Guardians Betting Insights

• The Cardinals have been favorites in 73 games this season and won 37 (50.7%) of those contests.
• St. Louis is 23-25 this season when entering a game favored by -123 or more on the moneyline.
• The Cardinals have a 55.2% chance to win this game based on the implied probability of the moneyline.
• The Guardians have won in 27, or 47.4%, of the 57 contests they have been named as odds-on underdogs this year.
• This season, Cleveland has been victorious 13 times in 39 chances when named as an underdog of at least +103 or longer on the moneyline.
• The moneyline set for this matchup implies the Guardians have a 49.3% chance of coming away with a victory in the contest.

FINAL

CLE 1 · STL 2

MLB

RUN LINE

TO WIN

TOTAL

Cleveland Guardians

CLE

+1.5

+108

O 7.5

St. Louis Cardinals

STL

-1.5

-128

U 7.5

Cardinals Recent Betting Performance

• The Cardinals went 3-2 over the five games they were moneyline favorites in their last 10 matchups.
• Over their last 10 matchups (all 10 of them had set totals), the Cardinals and their opponents combined to go over the run total three times.
• The Cardinals' ATS record is 7-3-0 over their past 10 games.

Cardinals Recent Stats

Cardinals Player Insights

• The Cardinals best hitter thus far this season is Donovan, who's hitting at a team-leading .273 rate along with 13 homers and 68 RBI.
• Including all MLB hitters, Donovan is 32nd in batting average, 40th in on-base percentage, and 80th in slugging.
• Alec Burleson's 21 home runs and 73 RBI both pace his team.
• Including all major league hitters, Burleson is 58th in homers and 51st in RBI.
• Nolan Arenado is batting .268 with 22 doubles, 16 home runs and 44 walks.
• Arenado is on a two-game hitting streak entering this contest. During his last five outings he is batting .313 with a double, three walks and two RBI.
• Masyn Winn is batting .267 with 28 doubles, four triples, 14 home runs and 39 walks.

Cardinals Team Props

Learn more about this Cardinals vs. Guardians matchup on Fox Sports.

Guardians Recent Betting Performance

• The Guardians have played as underdogs three times over their past 10 games and won each of those contests.
• In their last 10 games with a total, the Guardians and their opponents have failed to hit the over eight times.
• The Guardians are 5-5-0 ATS over their last 10 games.

Guardians Recent Stats

Guardians Player Insights

• Jose Ramirez paces the Guardians with 37 long balls and runs batted in, driving in 112.
• Among all hitters in the majors, Ramirez's home run total ranks seventh and his RBI tally ranks third.
• Naylor has 26 doubles, 31 home runs and 56 walks while batting .241.
• Among all MLB hitters, Naylor ranks 15th in home runs and seventh in RBI.
• Andres Gimenez is hitting .257 with 22 doubles, a triple, nine home runs and 26 walks.
• Lane Thomas is hitting .241 with 26 doubles, three triples, 14 home runs and 44 walks.

Guardians Team Props

Guardians vs. Cardinals Highlights | MLB on FOX

Check out the top moments between the Cleveland Guardians and the St. Louis Cardinals.

FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

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MLB - Cleveland Guardians vs. St. Louis Cardinals - 09/22/2024

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