Giants vs. Cardinals Prediction, Odds, Picks - September 27

Updated Sep. 26, 2024 6:01 p.m. ET

Data Skrive

The San Francisco Giants and Michael Conforto will square off against the St. Louis Cardinals and Masyn Winn on Friday at 10:15 p.m. ET in the first game of a three-game series at Oracle Park. The Giants are listed as -125 moneyline favorites for this matchup against the Cardinals (+105). St. Louis (-1.5) is the favorite on the run line. The matchup's over/under has been listed at 7.5 runs.

Here's everything you need to know from a betting perspective on the Giants-Cardinals game, regarding the run line, moneyline and total, plus expert picks.

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Check out the greatest moments and plays in this matchup between the San Francisco Giants and the Arizona Diamondbacks.

Giants vs. Cardinals Game Information & Odds

When: Friday, September 27, 2024 at 10:15 p.m. ET
Where: Oracle Park in San Francisco, California
How to Watch on TV: NBCS-BA

Favorite	Favorite Moneyline	Underdog Moneyline	Total	Over Total Odds	Under Total Odds	Run Line	Favorite Run Line Odds	Underdog Run Line Odds
Giants	-125	+105	7.5	-108	-112	-1.5	-230	+188

Giants vs. Cardinals Prediction

Score Prediction: Giants 4, Cardinals 3
Total Prediction: Under 7.5 runs
Win Probabilities: Giants 55%, Cardinals 45%

Giants vs. Cardinals Betting Insights

This season, the Giants have won 45 out of the 77 games, or 58.4%, in which they've been favored.
San Francisco has a record of 33-24, a 57.9% win rate, when favored by -125 or more by bookmakers this season.
The implied probability of a win from the Giants, based on the moneyline, is 55.6%.
The Cardinals have been victorious in 40, or 50%, of the 80 contests they have been chosen as underdogs in this season.
St. Louis has a mark of 21-34 in contests where oddsmakers favor it by +105 or worse on the moneyline.
Oddsmakers have implied with the moneyline set for this matchup that the Cardinals have a 48.8% chance of pulling out a win.

Giants Recent Betting Performance

The Giants were listed as the moneyline favorite by oddsmakers just one time over the last 10 games, and won that matchup.
In their last 10 outings -- all had a set run total -- the Giants and their opponents combined to hit the over on the total six times.
The Giants have put together an 8-2-0 record against the spread over their past 10 games.

Giants Recent Stats

Stat	Avg/Total
Record	7-3
Runs Per Game	5.3
HR	19
ERA	2.22
K/9	9.5

Giants Player Insights

The Giants' best power option comes in the form of Matt Chapman and his 27-homer 78-RBI season, both team highs.
Including all MLB hitters, Chapman ranks 85th in batting average, 58th in on-base percentage, and 39th in slugging.
Heliot Ramos' .273 batting average paces his team.
Ramos is 54th in homers and 64th in RBI among all batters in baseball.
Ramos carries a three-game streak with at least one hit into this contest. During his last five outings he is hitting .318 with a double, a home run, a walk and two RBI.
Conforto has 27 doubles, three triples, 20 home runs and 42 walks while hitting .234.
Conforto has at least one base hit in four games in a row. In his last five games he is hitting .238 with two doubles, two home runs, a walk and four RBI.
Mike Yastrzemski is hitting .232 with 15 doubles, nine triples, 18 home runs and 38 walks.
Yastrzemski has recorded at least one hit in two games in a row. During his last five outings he is batting .190 with a double, a home run and three RBI.

Learn more about this Giants vs. Cardinals matchup on Fox Sports.

Cardinals Recent Betting Performance

The Cardinals have played as underdogs in three of their past 10 games and won two of those contests.
In their last 10 games with a total, the Cardinals and their opponents have failed to hit the over eight times.
The Cardinals have won seven of their last 10 games against the spread.

Cardinals Recent Stats

Stat	Avg/Total
Record	7-3
Runs Per Game	4.2
HR	7
ERA	2.73
K/9	8.4

Cardinals Player Insights

Brendan Donovan leads the team in batting average with a mark of .272.
Donovan's home run total places him 151st in the big leagues, and he is 72nd in RBI.
Alec Burleson has been a reliable source of runs this year, leading the lineup with 21 home runs and 74 runs batted in.
Burleson ranks 61st in home runs and 52nd in RBI among all major league batters this year.
Winn is hitting .269 with 30 doubles, five triples, 15 home runs and 40 walks.
Nolan Arenado is hitting .269 with 22 doubles, 16 home runs and 44 walks.