Giants vs. Cardinals Prediction, Odds, Picks - September 28

Updated Sep. 28, 2024 1:01 a.m. ET

Data Skrive

Alec Burleson and the St. Louis Cardinals will hit the field on Saturday at Oracle Park against Blake Snell, who is starting for the San Francisco Giants. First pitch will be at 4:05 p.m. ET. The Cardinals are +116 moneyline underdogs for this matchup against the favorite Giants (-136). San Francisco is the run-line favorite (-1.5). The matchup's over/under is set at 7.5 runs.

Here's everything you need from a betting perspective on the Giants-Cardinals game, regarding the run line, moneyline and total, plus expert picks.

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Giants vs. Cardinals Game Information & Odds

When: Saturday, September 28, 2024 at 4:05 p.m. ET
Where: Oracle Park in San Francisco, California
How to Watch on TV: BSMW

Favorite	Favorite Moneyline	Underdog Moneyline	Total	Over Total Odds	Under Total Odds	Run Line	Favorite Run Line Odds	Underdog Run Line Odds
Giants	-136	+116	7.5	-102	-118	-1.5	+158	-190

Giants vs. Cardinals Prediction

Score Prediction: Giants 5, Cardinals 4
Total Prediction: Over 7.5 runs
Win Probabilities: Giants 54%, Cardinals 46%

Giants vs. Cardinals Betting Insights

The Giants have won 45, or 58.4%, of the 77 games they've played as favorites this season.
San Francisco has a record of 27-15 in games when sportsbooks favor them by at least -136 on the moneyline.
The sportsbooks' moneyline implies a 57.6% chance of a victory for the Giants.
The Cardinals have been victorious in 40, or 50%, of the 80 contests they have been chosen as underdogs in this season.
This season, St. Louis has come away with a win 13 times in 32 chances when named as an underdog of at least +116 or worse on the moneyline.
Bookmakers have implied with the moneyline set for this matchup that the Cardinals have a 46.3% chance of pulling out a win.

Giants Recent Betting Performance

The Giants were named the moneyline favorite by bookmakers just one time in the last 10 games, and won that matchup.
Over their last 10 matchups, the Giants and their opponents combined to go over the run total six times (all 10 of the games had set totals).
The Giants are 8-2-0 against the spread over their past 10 games.

Giants Recent Stats

Stat	Avg/Total
Record	7-3
Runs Per Game	5.3
HR	19
ERA	2.22
K/9	9.5

Giants Player Insights

Matt Chapman is the Giants best power hitter, connecting on 27 long balls this season in addition to delivering 78 RBI, both team highs.
Chapman's home runs rank him 29th in the majors, and he is 44th in RBI.
Heliot Ramos has a club-high .273 batting average.
Ramos ranks 56th in home runs and 67th in RBI among all hitters in the majors.
Ramos heads into this game looking for his fourth game in a row with a hit. During his last five outings he is hitting .318 with a double, a home run, a walk and two RBI.
Michael Conforto has 27 doubles, three triples, 20 home runs and 42 walks while batting .234.
Conforto is on a four-game hitting streak entering this contest. In his last five games he is batting .238 with two doubles, two home runs, a walk and four RBI.
Mike Yastrzemski is batting .232 with 15 doubles, nine triples, 18 home runs and 38 walks.
Yastrzemski takes a two-game streak with at least one hit into this one. In his last five games he is hitting .190 with a double, a home run and three RBI.

Learn more about this Giants vs. Cardinals matchup on Fox Sports.

Cardinals Recent Betting Performance

Over the past 10 games, the Cardinals have been underdogs twice and won both contests.
In their last 10 games with a total, the Cardinals and their opponents have failed to hit the over seven times.
The Cardinals have a record of 6-4-0 ATS over their last 10 games.

Cardinals Recent Stats

Stat	Avg/Total
Record	7-3
Runs Per Game	4.8
HR	10
ERA	3.34
K/9	8.4

Cardinals Player Insights

Brendan Donovan leads the Cardinals with a team-leading batting average of .274.
Among all hitters in the majors, Donovan's home run total is 153rd and his RBI tally is 76th.
Burleson has made the most of his opportunities as he paces his team with 74 RBI.
Burleson is 62nd among all batters in MLB in home runs, and 56th in RBI.
Masyn Winn is batting .267 with 30 doubles, five triples, 15 home runs and 40 walks.
Nolan Arenado has 22 doubles, 16 home runs and 44 walks while batting .269.