Giants vs. Guardians Prediction, Odds, Picks - September 12

Updated Sep. 12, 2023 10:00 a.m. ET

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LaMonte Wade Jr and the San Francisco Giants take on Steven Kwan and the Cleveland Guardians at Oracle Park on Tuesday, at 9:45 PM ET. The Giants are favored in this one, at -151, while the underdog Guardians have +128 odds to win. San Francisco is the favorite on the run line (-1.5). An 8.5-run over/under is set in this matchup.

The matchup on the mound for this contest is set with the San Francisco Giants looking to Sean Manaea (5-5), and Cal Quantrill (2-6) answering the bell for the Cleveland Guardians.

Here is everything you need to know from a betting perspective on the Giants-Guardians game, from the point spread, moneyline, Over/Under and expert picks (odds via FOX Bet):

Giants vs. Guardians Game Information & Odds

• When: Tuesday, September 12, 2023 at 9:45 PM ET
• Where: Oracle Park in San Francisco, California
• How to Watch on TV: MLB Network

Giants vs. Guardians Prediction

• Score Prediction: Giants 7, Guardians 6
• Total Prediction: Over 8.5 runs
• Win Probabilities: Giants 52%, Guardians 48%

Giants vs. Guardians Betting Insights

• The Giants have entered the game as favorites 73 times this season and won 41, or 56.2%, of those games.
• San Francisco has entered 33 games this season favored by -151 or more and is 18-15 in those contests.
• The implied probability of a win from the Giants, based on the moneyline, is 60.2%.
• The Guardians have been chosen as underdogs in 74 games this year and have walked away with the win 32 times (43.2%) in those games.
• This season, Cleveland has been victorious nine times in 26 chances when named as an underdog of at least +128 or longer on the moneyline.
• The moneyline set for this matchup implies the Guardians have a 43.9% chance of walking away with the win.

Giants Recent Betting Performance

• The Giants won all of the four games they played while the moneyline favorite over their last 10 matchups.
• In their last 10 outings (all 10 of them had set totals), the Giants and their opponents combined to go over the run total six times.
• The Giants have gone 2-8-0 against the spread over their past 10 games.

Giants Recent Stats

Place your bets on Giants vs. Guardians now with FOX Bet!

Giants Player Insights

• Wilmer Flores has homered 22 times this season, the highest mark on the Giants, while hitting .287 with 54 RBI.
• Wade has 14 doubles, a triple, 14 home runs and 68 walks while batting .258.
• Wade ranks 145th in home runs and 205th in RBI among all MLB hitters this season.
• Wade enters this matchup looking for his fourth game in a row with a hit. During his last five outings he is batting .438 with a home run, two walks and three RBI.
• Thairo Estrada paces the Giants with a .273 batting average.
• Estrada has at least one base hit in four games in a row. During his last five outings he is batting .261 with a triple, two home runs and four RBI.
• J.D. Davis has made the most of his opportunities as he paces his team with 65 RBI.

Giants Team Props

Learn more about this Giants vs. Guardians matchup on Fox Sports.

Guardians Recent Betting Performance

• In six games as underdogs over the last 10 matchups, the Guardians have a record of 2-4.
• When it comes to hitting the over, the Guardians and their opponents are 5-5-0 in their last 10 games with a total.
• The Guardians have won four of their last 10 games against the spread.

Guardians Recent Stats

Guardians Player Insights

• Jose Ramirez paces the Guardians with 22 homers while recording a team-best batting average of .273.
• In all of the big leagues, Ramirez ranks 53rd in home runs and 51st in RBI.
• Kwan is hitting .272 with 32 doubles, six triples, five home runs and 59 walks.
• Kwan ranks 303rd in home runs and 145th in RBI among all major league batters this season.
• Josh Naylor has racked up a team-best 87 runs batted in.
• Andres Gimenez is batting .240 with 25 doubles, four triples, 12 home runs and 32 walks.

Guardians Team Props

FOX Bet has the props and odds you need to get your betting on for Giants vs Guardians!

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