Giants vs. Padres Prediction, Odds, Picks - September 27

Updated Sep. 27, 2023 9:00 p.m. ET

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The San Francisco Giants versus San Diego Padres game on Wednesday at 9:45 PM ET will showcase a pair of hot hitters in LaMonte Wade Jr and Juan Soto. The Giants are the favorite in this one, at -119, while the underdog Padres have -100 odds to play spoiler. San Diego is the favorite on the run line (-1.5 with +160 odds). The total is 8.5 runs for this contest (with -115 odds to hit the over and -105 odds on the under).

The Giants will give the ball to Sean Manaea (7-6) versus the Padres and Matt Waldron (1-3).

Check out everything you need from a betting perspective on the Giants-Padres game, from the point spread, moneyline, Over/Under and expert picks.

Giants vs. Padres Game Information & Odds

• When: Wednesday, September 27, 2023 at 9:45 PM ET
• Where: Oracle Park in San Francisco, California
• How to Watch on TV: NBCS-BA

Giants vs. Padres Prediction

• Score Prediction: Padres 8, Giants 7
• Total Prediction: Over 8.5 runs
• Win Probabilities: Giants 50%, Padres 50%

Giants vs. Padres Betting Insights

• This season, the Giants have won 43 out of the 80 games, or 53.8%, in which they've been favored.
• This season San Francisco has won 38 of its 69 games, or 55.1%, when favored by at least -119 on the moneyline.
• Sportsbooks have implied with the moneyline set for this matchup that the Giants have a 54.3% chance to win.
• The Padres have been underdogs in 40 games this season and have come away with the win 13 times (32.5%) in those contests.
• San Diego has a win-loss record of 9-18 when favored by -100 or worse by bookmakers this year.
• The moneyline set for this matchup implies the Padres have a 50% chance of walking away with the win.

Giants Recent Betting Performance

• The Giants played as the moneyline favorite in three of their last 10 games, and finished 1-2 in those matchups.
• Over their last 10 matchups (all had set totals), the Giants combined with their opponents to hit the over on the total four times.
• The Giants' record against the spread is 3-7-0 over their past 10 games.

Giants Recent Stats

Giants Player Insights

• Wilmer Flores leads the Giants with 22 round-trippers on the year. He's also hitting .284 with 57 RBI.
• Wade is hitting .260 with 14 doubles, two triples, 17 home runs and 74 walks.
• Wade is 119th in homers in baseball, and 188th in RBI.
• Thairo Estrada paces the Giants with a .272 batting average.
• J.D. Davis' 69 runs batted in pace his team.
• Davis is riding a two-game hitting streak into this one. During his last five outings he is batting .214 with a double and a walk.

Giants Team Props

Learn more about this Giants vs. Padres matchup on Fox Sports.

Padres Recent Betting Performance

• The Padres are not favored for the first time in a while, as they have not been underdogs in their last 10 games.
• In their last 10 games with a total, the Padres and their opponents have combined to hit the over three times.
• The Padres have won seven of their last 10 games against the spread.

Padres Recent Stats

Padres Player Insights

• Soto has a team-leading 35 home runs and has driven in 108 runs.
• Soto's home run total puts him 13th in MLB, and he is fourth in RBI.
• Soto brings a hitting streak of five games into this game. During his last five outings he is hitting .524 with two doubles, three home runs, two walks and seven RBI.
• Fernando Tatis Jr. is hitting .264 with 33 doubles, a triple, 25 home runs and 52 walks.
• Tatis is 44th among all hitters in MLB in home runs, and 57th in RBI.
• Xander Bogaerts leads the Padres' lineup with a .283 batting average.
• Manny Machado is hitting .255 with 21 doubles, 30 home runs and 50 walks.

Padres Team Props

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