Guardians vs. Angels Prediction, Odds, Picks - April 5

Jose Ramirez and Taylor Ward will be among the stars on display when the Cleveland Guardians play the Los Angeles Angels on Saturday at 9:38 p.m. ET, at Angel Stadium. The Angels are +128 moneyline underdogs in this matchup against the Guardians (-153). Cleveland is the favorite on the run line (-1.5 with +116 odds). The total for the game has been set at 8.5 runs.

Here is everything you need to know from a betting perspective on the Guardians-Angels game, regarding the run line, moneyline and total, plus expert picks.

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Guardians vs. Angels Game Information & Odds

• When: Saturday, April 5, 2025 at 9:38 p.m. ET
• Where: Angel Stadium in Anaheim, California
• How to watch on TV: FDSW and CLEG

Guardians vs. Angels Prediction

• Score Prediction: Guardians 4, Angels 3
• Total Prediction: Under 8.5 runs
• Win Probabilities: Guardians 54%, Angels 46%

Guardians vs. Angels Betting Insights

• The Guardians won the only game they've played as the favorite this season.
• Cleveland has not been bigger favorites this season than the -153 moneyline set for this game.
• The oddsmakers' moneyline implies a 60.5% chance of a victory for the Guardians.
• The Angels have been chosen as underdogs in four games this year and have walked away with the win two times (50%) in those games.
• Los Angeles has played as an underdog of +128 or more just one time this year and came away with a win in that game.
• The Angels have an implied victory probability of 43.9% according to the moneyline set by oddsmakers for this matchup.

Guardians Player Insights

• The Guardians leader in both batting average and long balls is Ramirez, who comes into the matchup hitting .381 and has left the yard four times while driving in six runs this season.
• Among all hitters in the majors, Ramirez's home run total places him fourth, and his RBI tally ranks him 32nd.
• Ramirez carries a two-game hitting streak into this matchup. In his last five games he is hitting .471 with two doubles, four home runs, two walks and five RBI.
• Kyle Manzardo's eight runs batted in lead his team.
• Manzardo is 33rd in homers and 13th in RBI among all major league hitters this season.
• Steven Kwan has a double, a home run and three walks while batting .333.
• Kwan has at least one base hit in three games in a row. In his last five games he is hitting .300 with two walks and an RBI.
• Gabriel Arias is batting .333 with a double, a home run and two walks.
• Arias is riding a five-game hitting streak into this one. In his last five games he is hitting .375 with a home run, two walks and two RBI.

Guardians Team Props

Angels Player Insights

• Kyren Paris is batting .545 with a triple, a home run and two walks.
• Paris ranks 71st in home runs and 109th in RBI among all hitters in MLB.
• Paris carries a five-game hitting streak into this matchup. During his last five outings he is hitting .600 with a triple, a home run, two walks and three RBI.
• Mike Trout has totaled six runs batted in to lead his team.
• Trout is 33rd overall in home runs and 32nd in RBI this season.
• Nolan Schanuel paces the Angels with a team-high batting average of .286.
• Logan O'Hoppe leads the Angels with three home runs and runs batted in, driving in six.

Angels Team Props

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FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

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Los Angeles Angels

Cleveland Guardians