Guardians vs. Astros Prediction, Odds, Picks - September 27

Updated Sep. 26, 2024 7:01 p.m. ET

Data Skrive

Joey Cantillo starts for the Cleveland Guardians on Friday against Yordan Alvarez and the Houston Astros. First pitch is at 7:10 p.m. ET at Progressive Field. The Guardians are -123 moneyline favorites in this matchup against the Astros (+103). Cleveland is the run-line favorite (-1.5). An 8-run over/under has been set for the matchup.

Take a look at everything you need to know from a betting perspective on the Guardians-Astros game, regarding the run line, moneyline and total, plus expert picks.

Reds vs. Guardians Highlights | MLB on FOX

Check out the greatest moments and plays in this matchup between the Cincinnati Reds and the Cleveland Guardians.

Guardians vs. Astros Game Information & Odds

When: Friday, September 27, 2024 at 7:10 p.m. ET
Where: Progressive Field in Cleveland, Ohio
How to Watch on TV: MLB Network

Favorite	Favorite Moneyline	Underdog Moneyline	Total	Over Total Odds	Under Total Odds	Run Line	Favorite Run Line Odds	Underdog Run Line Odds
Guardians	-123	+103	8	-105	-115	-1.5	+165	-200

Guardians vs. Astros Prediction

Score Prediction: Guardians 5, Astros 4
Total Prediction: Over 8 runs
Win Probabilities: Guardians 53%, Astros 47%

Guardians vs. Astros Betting Insights

The Guardians have been favorites in 99 games this season and won 65 (65.7%) of those contests.
Cleveland has a record of 52-24, a 68.4% win rate, when favored by -123 or more by bookmakers this season.
The Guardians have a 55.2% chance to win this game based on the implied probability of the moneyline.
The Astros have been chosen as underdogs in 42 games this year and have walked away with the win 19 times (45.2%) in those games.
This year, Houston has won 10 of 21 games when listed as at least +103 or worse on the moneyline.
The Astros have an implied victory probability of 49.3% according to the moneyline set by oddsmakers for this matchup.

Guardians Recent Betting Performance

The Guardians have a 4-2 record across the six games they were a moneyline favorite in their last 10 matchups.
Over their last 10 outings -- all had a set run total -- the Guardians and their opponents combined to hit the over on the total two times.
The Guardians' ATS record is 7-3-0 over their past 10 games.

Guardians Recent Stats

Stat	Avg/Total
Record	7-3
Runs Per Game	3.7
HR	14
ERA	1.70
K/9	8.9

Guardians Player Insights

Jose Ramirez has accumulated a team-best 38 home runs and 115 runs batted in.
Ramirez's home runs place him sixth in the majors, and he is third in RBI.
Ramirez brings a hitting streak of two games into this game. In his last five games he is batting .500 with three doubles, a triple, three home runs and eight RBI.
Josh Naylor has 27 doubles, 31 home runs and 57 walks while hitting .243.
Naylor ranks 15th in home runs and seventh in RBI among all MLB hitters this season.
Naylor has two straight games with at least one hit. During his last five outings he is hitting .188 with a double, two walks and three RBI.
Steven Kwan has accumulated a team-high batting average of .292.
Kwan is on a five-game hitting streak entering this contest. In his last five games he is batting .412 with a home run, six walks and an RBI.
Andres Gimenez is batting .253 with 22 doubles, a triple, nine home runs and 26 walks.

Learn more about this Guardians vs. Astros matchup on Fox Sports.

Astros Recent Betting Performance

In four games as underdogs over the last 10 matchups, the Astros have a record of 1-3.
The Astros and their opponents have combined to hit the over four times in their last 10 games with a total.
The Astros have four wins against the spread in their last 10 chances.

Astros Recent Stats

Stat	Avg/Total
Record	5-5
Runs Per Game	4.1
HR	12
ERA	4.35
K/9	10.0

Astros Player Insights

Alvarez leads the Astros with 35 home runs and 86 runs batted in, while recording a team-high batting average of .308.
Among all batters in the majors, Alvarez ranks 10th in homers and 30th in RBI.
Jose Altuve has 29 doubles, 20 home runs and 46 walks while batting .293.
Altuve ranks 75th in homers and 85th in RBI among all hitters in MLB.
Alex Bregman is batting .256 with 28 doubles, two triples, 26 home runs and 44 walks.
Yainer Diaz is batting .299 with 29 doubles, three triples, 16 home runs and 23 walks.