Guardians vs. Astros Prediction, Odds, Picks - September 28

Updated Sep. 27, 2024 10:01 p.m. ET

Data Skrive

Jose Ramirez and the Cleveland Guardians take on Jose Altuve and the Houston Astros on Saturday at 6:10 p.m. ET, in the first of a three-game series at Progressive Field. The Guardians have been listed as -117 moneyline favorites for this matchup with the Astros (-102). Cleveland is the favorite on the run line (-1.5 with +178 odds). The total for the matchup has been listed at 8 runs.

Here's everything you need from a betting perspective on the Guardians-Astros game, regarding the run line, moneyline and total, plus expert picks.

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Guardians vs. Astros Game Information & Odds

When: Saturday, September 28, 2024 at 6:10 p.m. ET
Where: Progressive Field in Cleveland, Ohio
How to Watch on TV: BSGL

Favorite	Favorite Moneyline	Underdog Moneyline	Total	Over Total Odds	Under Total Odds	Run Line	Favorite Run Line Odds	Underdog Run Line Odds
Guardians	-117	-102	8	-106	-114	-1.5	+178	-216

Guardians vs. Astros Prediction

Score Prediction: Guardians 4, Astros 3
Total Prediction: Under 8 runs
Win Probabilities: Guardians 53%, Astros 47%

Guardians vs. Astros Betting Insights

This season, the Guardians have won 65 out of the 99 games, or 65.7%, in which they've been favored.
This season Cleveland has won 55 of its 81 games, or 67.9%, when favored by at least -117 on the moneyline.
The Guardians have a 53.9% chance to win this game based on the implied probability of the moneyline.
The Astros have won in 19, or 45.2%, of the 42 contests they have been named as odds-on underdogs this year.
This year, Houston has won 12 of 27 games when listed as at least -102 or worse on the moneyline.
The moneyline set for this matchup implies the Astros have a 50.5% chance of coming away with a victory in the contest.

Guardians Recent Betting Performance

The Guardians were favored on the moneyline in six of their last 10 games, and they went 4-2 in those matchups.
Over their last 10 outings (all 10 of them had set totals), the Guardians and their opponents combined to hit the over two times.
The Guardians are 7-3-0 against the spread over their past 10 games.

Guardians Recent Stats

Stat	Avg/Total
Record	7-3
Runs Per Game	3.7
HR	14
ERA	1.70
K/9	8.9

Guardians Player Insights

Ramirez leads the Guardians in home runs (38) and runs batted in (115).
Including all MLB hitters, Ramirez ranks 26th in batting average, 44th in on-base percentage, and 11th in slugging.
Ramirez brings a hitting streak of two games into this matchup. During his last five outings he is batting .500 with three doubles, a triple, three home runs and eight RBI.
Josh Naylor is batting .243 with 27 doubles, 31 home runs and 57 walks.
Naylor ranks 15th in homers and seventh in RBI among all batters in baseball.
Naylor has two straight games with at least one hit. During his last five outings he is hitting .188 with a double, two walks and three RBI.
Steven Kwan paces the Guardians with a .292 batting average.
Kwan has at least one base hit in five games in a row. During his last five outings he is batting .412 with a home run, six walks and an RBI.
Andres Gimenez is hitting .253 with 22 doubles, a triple, nine home runs and 26 walks.

Learn more about this Guardians vs. Astros matchup on Fox Sports.

Astros Recent Betting Performance

The Astros have played as underdogs in four of their past 10 games and have gone 1-3 in those contests.
The Astros and their opponents have combined to hit the over four times in their last 10 games with a total.
Over their last 10 games, the Astros are 4-6-0 against the spread.

Astros Recent Stats

Stat	Avg/Total
Record	5-5
Runs Per Game	4.1
HR	12
ERA	4.35
K/9	10

Astros Player Insights

Yordan Alvarez leads the Astros with 35 home runs and 86 runs batted in, while posting a team-best batting average of .308.
Alvarez's home run total places him 10th in the majors, and he is 30th in RBI.
Altuve is batting .293 with 29 doubles, 20 home runs and 46 walks.
Altuve ranks 75th in home runs and 85th in RBI among all MLB hitters this season.
Alex Bregman is batting .256 with 28 doubles, two triples, 26 home runs and 44 walks.
Yainer Diaz is hitting .299 with 29 doubles, three triples, 16 home runs and 23 walks.