Guardians vs. Astros Prediction, Odds, Picks - September 28

Updated Sep. 28, 2024 6:01 p.m. ET

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Jose Ramirez and Alex Bregman will look to continue their recent offensive production when the Cleveland Guardians and Houston Astros take the field at Progressive Field on Saturday, at 6:10 p.m. ET. The Guardians have been listed as -143 moneyline favorites for this matchup with the Astros (+120). Cleveland is the favorite on the run line (-1.5). The over/under is 7.5 runs for the game (with -112 odds to go over and -108 odds on the under).

Here's everything you need from a betting perspective on the Guardians-Astros game, regarding the run line, moneyline and total, plus expert picks.

Astros vs. Guardians Highlights | MLB on FOX

Check out the top moments between the Houston Astros and the Cleveland Guardians.

Guardians vs. Astros Game Information & Odds

• When: Saturday, September 28, 2024 at 6:10 p.m. ET
• Where: Progressive Field in Cleveland, Ohio
• How to Watch on TV: BSGL

Guardians vs. Astros Prediction

• Score Prediction: Guardians 4, Astros 3
• Total Prediction: Under 7.5 runs
• Win Probabilities: Guardians 53%, Astros 47%

Guardians vs. Astros Betting Insights

• This season, the Guardians have been favored 100 times and won 65, or 65%, of those games.
• Cleveland has a record of 28-15 in games when sportsbooks favor them by at least -143 on the moneyline.
• Bookmakers have implied with the moneyline set for this matchup that the Guardians have a 58.8% chance to win.
• The Astros have been chosen as underdogs in 43 games this year and have walked away with the win 20 times (46.5%) in those games.
• Houston has a mark of 5-5 in contests where sportsbooks favor it by +120 or worse on the moneyline.
• The moneyline set for this matchup implies the Astros have a 45.5% chance of walking away with the win.

FINAL

HOU 4 · CLE 3

MLB

RUN LINE

TO WIN

TOTAL

Houston Astros

HOU

+1.5

+130

O 7.5

Cleveland Guardians

CLE

-1.5

-154

U 7.5

Guardians Recent Betting Performance

• The Guardians went 3-3 across the six games they were a moneyline favorite in their last 10 matchups.
• In their last 10 matchups, the Guardians and their opponents combined to hit the over on the run total two times (all 10 games had set totals).
• The Guardians are 6-4-0 against the spread over their past 10 games.

Guardians Recent Stats

Guardians Player Insights

• The Guardians' best power option comes in the form of Ramirez and his 38-dinger 115-RBI season, both team highs.
• Including all MLB hitters, Ramirez is 29th in batting average, 43rd in on-base percentage, and 11th in slugging.
• Josh Naylor has 27 doubles, 31 home runs and 58 walks while hitting .242.
• Naylor is 17th in home runs and eighth in RBI in the bigs.
• Steven Kwan leads the Guardians with a team-high batting average of .292.
• Andres Gimenez has 22 doubles, a triple, nine home runs and 26 walks while hitting .252.

Guardians Team Props

Learn more about this Guardians vs. Astros matchup on Fox Sports.

Astros Recent Betting Performance

• In four games as underdogs over the last 10 matchups, the Astros have a record of 2-2.
• In their last 10 games with a total, the Astros and their opponents have combined to hit the over four times.
• The Astros have a record of 5-5-0 ATS over their last 10 games.

Astros Recent Stats

Astros Player Insights

• Yordan Alvarez paces the Astros in home runs (35), runs batted in (86) and has a team-best batting average of .308.
• Alvarez ranks 10th in home runs and 31st in RBI among all hitters in MLB.
• Jose Altuve is hitting .295 with 31 doubles, 20 home runs and 47 walks.
• Altuve ranks 75th among all hitters in the majors in homers, and 85th in RBI.
• Bregman is batting .260 with 30 doubles, two triples, 26 home runs and 44 walks.
• Yainer Diaz is hitting .299 with 29 doubles, three triples, 16 home runs and 24 walks.

Astros Team Props

Astros vs. Guardians Highlights | MLB on FOX

Check out the top moments between the Houston Astros and the Cleveland Guardians.

FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

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MLB - Houston Astros vs. Cleveland Guardians - 09/28/2024

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