Guardians vs. Astros Prediction, Odds, Picks - September 29

Updated Sep. 29, 2024 8:02 a.m. ET

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Josh Naylor and the Cleveland Guardians will hit the field against the Houston Astros and Alex Bregman at Progressive Field on Sunday at 3:10 p.m. ET. The Guardians are favored in this one, at -186, while the underdog Astros have +154 odds to upset. Cleveland is the run-line favorite (-1.5). The contest's total is set at 7.5 runs.

Take a look at everything you need to know from a betting perspective on the Guardians-Astros game, regarding the run line, moneyline and total, plus expert picks.

Astros vs. Guardians Highlights | MLB on FOX

Check out the greatest plays and moments in this matchup between the Houston Astros and the Cleveland Guardians.

Guardians vs. Astros Game Information & Odds

• When: Sunday, September 29, 2024 at 3:10 p.m. ET
• Where: Progressive Field in Cleveland, Ohio
• How to Watch on TV: BSGL

Guardians vs. Astros Prediction

• Score Prediction: Guardians 5, Astros 4
• Total Prediction: Over 7.5 runs
• Win Probabilities: Guardians 53%, Astros 47%

Guardians vs. Astros Betting Insights

• The Guardians have been favorites in 101 games this season and won 65 (64.4%) of those contests.
• This season Cleveland has won nine of its 14 games, or 64.3%, when favored by at least -186 on the moneyline.
• The implied probability of a win from the Guardians, based on the moneyline, is 65%.
• The Astros have been underdogs in 44 games this season and have come away with the win 21 times (47.7%) in those contests.
• Houston has played as an underdog of +154 or more just one time this year and came away with a loss in that game.
• The Astros have an implied victory probability of 39.4% according to the moneyline set for this matchup.

Sun 7:10 PM

BSGL

MLB

RUN LINE

TO WIN

TOTAL

Houston Astros

HOU

+1.5

+154

O 7.5

Cleveland Guardians

CLE

-1.5

-185

U 7.5

Guardians Recent Betting Performance

• The Guardians went 3-4 across the seven games they were moneyline favorites in their last 10 matchups.
• In their last 10 matchups, the Guardians and their opponents combined to go over the run total two times (all 10 of the games had set totals).
• The Guardians' ATS record is 5-5-0 over their past 10 games.

Guardians Recent Stats

Guardians Player Insights

• Jose Ramirez paces the Guardians in home runs (39) and runs batted in (118).
• In all of Major League Baseball, Ramirez ranks fifth in home runs and third in RBI.
• Naylor has 27 doubles, 31 home runs and 58 walks while batting .243.
• Naylor is 17th in home runs and eighth in RBI among all MLB batters this year.
• Steven Kwan paces the Guardians with a team-best batting average of .292.
• Andres Gimenez is hitting .252 with 22 doubles, a triple, nine home runs and 26 walks.

Guardians Team Props

Learn more about this Guardians vs. Astros matchup on Fox Sports.

Astros Recent Betting Performance

• In four games over the last 10 matchups when set as underdogs by bookmakers, the Astros had a record of 2-2.
• When it comes to hitting the over, the Astros and their opponents are 4-5-1 in their last 10 games with a total.
• Over their last 10 games, the Astros are 5-5-0 against the spread.

Astros Recent Stats

Astros Player Insights

• Yordan Alvarez leads the lineup with a batting average of .308, and paces the Astros in home runs, with 35 and runs batted in with 86.
• Alvarez ranks 10th in homers and 31st in RBI among all batters in the big leagues.
• Jose Altuve is batting .295 with 31 doubles, 20 home runs and 47 walks.
• Altuve ranks 77th among all hitters in the majors in homers, and 86th in RBI.
• Bregman is batting .260 with 30 doubles, two triples, 26 home runs and 44 walks.
• Yainer Diaz is hitting .299 with 29 doubles, three triples, 16 home runs and 24 walks.

Astros Team Props

Astros vs. Guardians Highlights | MLB on FOX

Check out the greatest plays and moments in this matchup between the Houston Astros and the Cleveland Guardians.

FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

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MLB - Houston Astros vs. Cleveland Guardians - 09/29/2024

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