Guardians vs. Astros Prediction, Odds, Picks - September 29

Updated Sep. 29, 2024 2:01 p.m. ET

Data Skrive

Jose Ramirez and the Cleveland Guardians play Yordan Alvarez and the Houston Astros at Progressive Field on Sunday. First pitch is at 3:10 p.m. ET. The Astros have been listed as +121 moneyline underdogs for this matchup against the Guardians (-141). Cleveland is favored on the run line (-1.5 with +143 odds). A 7.5-run over/under has been set for the matchup.

Here is everything you need to know from a betting perspective on the Guardians-Astros game, regarding the run line, moneyline and total, plus expert picks.

Astros vs. Guardians Highlights | MLB on FOX

Check out the greatest plays and moments in this matchup between the Houston Astros and the Cleveland Guardians.

Guardians vs. Astros Game Information & Odds

When: Sunday, September 29, 2024 at 3:10 p.m. ET
Where: Progressive Field in Cleveland, Ohio
How to Watch on TV: BSGL

Favorite	Favorite Moneyline	Underdog Moneyline	Total	Over Total Odds	Under Total Odds	Run Line	Favorite Run Line Odds	Underdog Run Line Odds
Guardians	-141	+121	7.5	-114	-107	-1.5	+143	-171

Guardians vs. Astros Prediction

Score Prediction: Guardians 5, Astros 4
Total Prediction: Over 7.5 runs
Win Probabilities: Guardians 53%, Astros 47%

Guardians vs. Astros Betting Insights

The Guardians have won 65, or 64.4%, of the 101 games they've played as favorites this season.
Cleveland has entered 46 games this season favored by -141 or more and is 29-17 in those contests.
The implied probability of a win from the Guardians, based on the moneyline, is 58.5%.
The Astros have been victorious in 21, or 47.7%, of the 44 contests they have been chosen as underdogs in this season.
This season, Houston has been victorious six times in 11 chances when named as an underdog of at least +121 or longer on the moneyline.
The moneyline set for this matchup implies the Astros have a 45.2% chance of coming away with a victory in the contest.

Guardians Recent Betting Performance

The Guardians were the moneyline favorite in seven of their last 10 games, and they went 3-4 in those matchups.
Over their last 10 outings -- all had a set run total -- the Guardians and their opponents combined to hit the over on the total two times.
The Guardians' ATS record is 5-5-0 over their past 10 games.

Guardians Recent Stats

Stat	Avg/Total
Record	5-5
Runs Per Game	3.6
HR	14
ERA	2.20
K/9	8.9

Guardians Player Insights

Ramirez has a team-high 39 home runs and 118 runs batted in.
Ramirez is fifth in homers and third in RBI among all hitters in baseball.
Josh Naylor is batting .243 with 27 doubles, 31 home runs and 58 walks.
Including all MLB hitters, Naylor is 17th in homers and eighth in RBI.
Steven Kwan leads the Guardians with a .292 batting average.
Andres Gimenez is hitting .252 with 22 doubles, a triple, nine home runs and 26 walks.

Guardians Team Props

	Hits O/U	Total Bases O/U	HR O/U	RBI O/U
Steven Kwan	0.5 (-270)	1.5 (+120)	-	0.5 (+220)
Andrés Giménez	0.5 (-225)	1.5 (+145)	-	0.5 (+210)
José Ramírez	0.5 (-260)	1.5 (+105)	-	0.5 (+140)
Josh Naylor	0.5 (-215)	1.5 (+135)	-	0.5 (+140)
Lane Thomas	0.5 (-180)	0.5 (-180)	-	0.5 (+175)

Learn more about this Guardians vs. Astros matchup on Fox Sports.

Astros Recent Betting Performance

The Astros have played as underdogs in four of their past 10 games and won two of those contests.
The Astros and their opponents have combined to hit the over four times in their last 10 games with a total.
The Astros have a record of 5-5-0 ATS over their last 10 games.

Astros Recent Stats

Stat	Avg/Total
Record	6-4
Runs Per Game	4.5
HR	14
ERA	4.25
K/9	10.5

Astros Player Insights

Alvarez leads the Astros with 35 home runs and 86 runs batted in, while posting a team-best batting average of .308.
Alvarez's home run total places him 10th in the big leagues, and he ranks 31st in RBI.
Jose Altuve has 31 doubles, 20 home runs and 47 walks while batting .295.
Among all major league batters, Altuve is 77th in home runs and 86th in RBI.
Alex Bregman has 30 doubles, two triples, 26 home runs and 44 walks while batting .260.
Yainer Diaz is batting .299 with 29 doubles, three triples, 16 home runs and 24 walks.

Astros Team Props

	Hits O/U	Total Bases O/U	HR O/U	RBI O/U
Yainer Diaz	0.5 (-275)	1.5 (+110)	-	0.5 (+150)
Jeremy Pena	0.5 (-235)	1.5 (+125)	-	0.5 (+195)
Jose Altuve	0.5 (-235)	1.5 (+130)	-	0.5 (+230)
Alex Bregman	0.5 (-245)	1.5 (+110)	-	0.5 (+145)
Kyle Tucker	0.5 (-230)	1.5 (+110)	-	0.5 (+170)