Guardians vs. Orioles Prediction, Odds, Picks - September 22

Updated Sep. 22, 2023 7:05 p.m. ET

Data Skrive

Adley Rutschman and the Baltimore Orioles hit the field against Steven Kwan and the Cleveland Guardians at Progressive Field on Friday at 7:10 PM ET. Oddsmakers list the Guardians as -118 favorites on the moneyline, while giving the underdog Orioles -101 moneyline odds. Cleveland is a 1.5-run favorite (at +175 odds). The over/under is 8 runs for this contest (with -109 odds to go over and -111 odds to go under).

The starting pitchers are Shane Bieber (5-6) for the Cleveland Guardians, and Dean Kremer (12-5) for the Baltimore Orioles.

Check out everything you need from a betting perspective on the Guardians-Orioles game, from the point spread, moneyline, Over/Under and expert picks.

Guardians vs. Orioles Game Information & Odds

When: Friday, September 22, 2023 at 7:10 PM ET
Where: Progressive Field in Cleveland, Ohio
How to Watch on TV: BSGL

Favorite	Favorite Moneyline	Underdog Moneyline	Total	Over Total Odds	Under Total Odds	Run Line	Favorite Run Line Odds	Underdog Run Line Odds
Guardians	-118	-101	8	-109	-111	-1.5	+175	-211

Guardians vs. Orioles Prediction

Score Prediction: Orioles 5, Guardians 4
Total Prediction: Over 8 runs
Win Probabilities: Guardians 52%, Orioles 48%

Guardians vs. Orioles Betting Insights

The Guardians have entered the game as favorites 73 times this season and won 37, or 50.7%, of those games.
Cleveland has entered 65 games this season favored by -118 or more and is 32-33 in those contests.
The sportsbooks' moneyline implies a 54.1% chance of a victory for the Guardians.
The Orioles have been underdogs in 74 games this season and have come away with the win 43 times (58.1%) in those contests.
Baltimore has a mark of 37-24 in contests where oddsmakers favor it by -101 or worse on the moneyline.
The moneyline set for this matchup implies the Orioles have a 50.2% chance of walking away with the win.

Guardians Recent Betting Performance

The Guardians were the moneyline favorite for four of their last 10 games, and they went 1-3 in those matchups.
Over their last 10 matchups (all had set totals), the Guardians combined with their opponents to go over the run total six times.
The Guardians are 6-4-0 against the spread over their past 10 games.

Guardians Recent Stats

Stat	Avg/Total
Record	5-5
Runs Per Game	5.2
HR	8
ERA	3.41
K/9	8.5

Guardians Player Insights

Jose Ramirez's .277 average and 24 homers both put him atop the Guardians leaderboard this season.
Of all batters in MLB, Ramirez's home run total ranks him 48th, and his RBI tally ranks him 47th.
Kwan has 34 doubles, seven triples, five home runs and 68 walks while hitting .275.
Kwan is 305th in homers in baseball, and 141st in RBI.
Kwan carries a two-game streak with at least one hit into this contest. In his last five games he is hitting .368 with two doubles, a triple, six walks and four RBI.
Josh Naylor paces the Guardians with 94 runs batted in.
Andres Gimenez is hitting .249 with 26 doubles, five triples, 13 home runs and 32 walks.
Gimenez is riding a five-game hitting streak into this one. During his last five outings he is hitting .476 with a double, a triple and five RBI.

Learn more about this Guardians vs. Orioles matchup on Fox Sports.

Orioles Recent Betting Performance

The Orioles have played as underdogs in four of their past 10 games and won three of those contests.
In their last 10 games with a total, the Orioles and their opponents have combined to hit the over three times.
The Orioles have four wins against the spread in their last 10 chances.

Orioles Recent Stats

Stat	Avg/Total
Record	4-6
Runs Per Game	3.9
HR	10
ERA	3.70
K/9	6.8

Orioles Player Insights

Rutschman has 29 doubles, a triple, 19 home runs and 85 walks while hitting .273.
Rutschman is 92nd in homers and 60th in RBI among all hitters in the big leagues.
Rutschman brings a hitting streak of five games into this game. In his last five games he is batting .474 with five doubles, a home run, two walks and five RBI.
Gunnar Henderson has launched a team-best 27 home runs.
Henderson ranks 31st in homers and 45th in RBI among all hitters in the big leagues.
Anthony Santander paces the Orioles in home runs (27) and runs batted in (86).
Austin Hays leads the Orioles with a .277 batting average.