Orioles vs. Cardinals Prediction, Odds, Picks - May 21

Updated May. 21, 2024 7:00 p.m. ET

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Lance Lynn will take the mound for the St. Louis Cardinals against the Baltimore Orioles and Gunnar Henderson on Tuesday at 7:45 PM ET. The favored Orioles have -148 moneyline odds to win against the underdog Cardinals, who are listed at +125. Baltimore is a 1.5-run favorite (at +109 odds). The over/under for the contest has been set at 9 runs.

Here's everything you need from a betting perspective on the Orioles-Cardinals game, regarding the run line, moneyline and total, plus expert picks.

Orioles vs. Cardinals Highlights | MLB on FOX

Check out the best moments between the Baltimore Orioles and the St. Louis Cardinals.

Orioles vs. Cardinals Game Information & Odds

• When: Tuesday, May 21, 2024 at 7:45 PM ET
• Where: Busch Stadium in St. Louis, Missouri
• How to Watch on TV: MASN2

Orioles vs. Cardinals Prediction

• Score Prediction: Orioles 5, Cardinals 4
• Total Prediction: Over 9 runs
• Win Probabilities: Orioles 54%, Cardinals 46%

Orioles vs. Cardinals Betting Insights

• This season, the Orioles have been favored 36 times and won 22, or 61.1%, of those games.
• Baltimore has a record of 9-7, a 56.2% win rate, when favored by -148 or more by sportsbooks this season.
• The implied probability of a win from the Orioles, based on the moneyline, is 59.7%.
• The Cardinals have been victorious in nine, or 40.9%, of the 22 contests they have been chosen as underdogs in this season.
• St. Louis has a win-loss record of 3-5 when favored by +125 or worse by bookmakers this year.
• The Cardinals have an implied victory probability of 44.4% according to the moneyline set by sportsbooks for this matchup.

FINAL

BAL 1 · STL 3

MLB

RUN LINE

TO WIN

TOTAL

Baltimore Orioles

BAL

-1.5

-148

O 9

St. Louis Cardinals

STL

+1.5

+125

U 9

Orioles Recent Betting Performance

• The Orioles went 6-3 across the nine games they were a moneyline favorite in their last 10 matchups.
• In their last 10 matchups -- all had a set run total -- the Orioles and their opponents combined to go over the total six times.
• The Orioles' ATS record is 3-7-0 over their past 10 games.

Orioles Recent Stats

Orioles Player Insights

• Henderson has gone yard 16 times in the 2024 campaign while driving in 34 runs, both totals that lead the Orioles.
• Henderson's home runs rank him first in MLB, and he is 10th in RBI.
• Henderson has collected a hit in four games in a row. During his last five outings he is hitting .333 with a triple, four home runs, four walks and seven RBI.
• Adley Rutschman has a club-best .304 batting average.
• Rutschman is 22nd in home runs and 33rd in RBI in the bigs.
• Jordan Westburg is batting .294 with nine doubles, three triples, seven home runs and 11 walks.
• Westburg will look to build on his three-game hitting in this game. In his last five games he is batting .263 with a triple, a home run, a walk and two RBI.
• Anthony Santander is hitting .205 with 11 doubles, a triple, seven home runs and 13 walks.

Orioles Team Props

Learn more about this Orioles vs. Cardinals matchup on Fox Sports.

Cardinals Recent Betting Performance

• In five games as underdogs over the last 10 matchups, the Cardinals have a record of 2-3.
• In their last 10 games with a total, the Cardinals and their opponents have combined to hit the over nine times.
• Over their last 10 games, the Cardinals are 5-5-0 against the spread.

Cardinals Recent Stats

Cardinals Player Insights

• Brendan Donovan is hitting .232 with 11 doubles, a triple, four home runs and 17 walks, while getting on base at a rate of .311.
• Among all hitters in the big leagues, Donovan ranks 130th in homers and 81st in RBI.
• Donovan carries an eight-game hitting streak into this matchup. In his last 10 outings he is batting .262 with three doubles, six walks and two RBI.
• Nolan Arenado has capitalized on opportunities as he paces his team with 22 runs batted in.
• Arenado ranks 168th in home runs and 71st in RBI among all hitters in the majors.
• Lars Nootbaar has seven doubles, five home runs and 22 walks while batting .213.
• Alec Burleson has six doubles, five home runs and six walks while hitting .301.

Cardinals Team Props

Orioles vs. Cardinals Highlights | MLB on FOX

Check out the best moments between the Baltimore Orioles and the St. Louis Cardinals.

FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

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