Orioles vs. Cardinals Prediction, Odds, Picks - May 22

Updated May. 22, 2024 1:00 p.m. ET

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Lars Nootbaar and the St. Louis Cardinals hit the field on Wednesday at Busch Stadium against John Means, who is projected to start for the Baltimore Orioles. First pitch is at 1:15 PM ET. Bookmakers list the Orioles as -126 favorites on the moneyline, while giving the underdog Cardinals +106 moneyline odds. Baltimore is the favorite on the run line (-1.5). The total is 9 runs for this game (with -110 odds to go over and -110 odds on the under).

Check out everything you need to know from a betting perspective on the Orioles-Cardinals game, regarding the run line, moneyline and total, plus expert picks.

Orioles vs. Cardinals Highlights | MLB on FOX

Check out the best moments between the Baltimore Orioles and the St. Louis Cardinals.

Orioles vs. Cardinals Game Information & Odds

• When: Wednesday, May 22, 2024 at 1:15 PM ET
• Where: Busch Stadium in St. Louis, Missouri
• How to Watch on TV: MASN2

Orioles vs. Cardinals Prediction

• Score Prediction: Orioles 5, Cardinals 4
• Total Prediction: Under 9 runs
• Win Probabilities: Orioles 54%, Cardinals 46%

Orioles vs. Cardinals Betting Insights

• The Orioles have entered the game as favorites 36 times this season and won 22, or 61.1%, of those games.
• Baltimore has a record of 18-13 in games when bookmakers favor them by at least -126 on the moneyline.
• Sportsbooks have implied with the moneyline set for this matchup that the Orioles have a 55.8% chance to win.
• The Cardinals have been chosen as underdogs in 22 games this year and have walked away with the win nine times (40.9%) in those games.
• St. Louis has a win-loss record of 4-9 when favored by +106 or worse by oddsmakers this year.
• The Cardinals have an implied victory probability of 48.5% according to the moneyline set by sportsbooks for this matchup.

Orioles Recent Betting Performance

• The Orioles went 6-3 over the nine games they were moneyline favorites in their last 10 matchups.
• Over their last 10 outings (all 10 of them had set totals), the Orioles and their opponents combined to hit the over six times.
• The Orioles have gone 3-7-0 against the spread over their past 10 games.

Orioles Recent Stats

Orioles Player Insights

• Gunnar Henderson is the Orioles best power option, connecting on 16 round-trippers this season in addition to accumulating 34 RBI, both team highs.
• Including all MLB batters, Henderson is 42nd in batting average, 36th in on-base percentage, and fourth in slugging.
• Henderson has collected a hit in four straight games. During his last five outings he is hitting .333 with a triple, four home runs, four walks and seven RBI.
• Adley Rutschman's .304 batting average is a team-high mark.
• Rutschman is 22nd in home runs in baseball, and 36th in RBI.
• Jordan Westburg has nine doubles, three triples, seven home runs and 11 walks while batting .294.
• Westburg has at least one base hit in three straight games. During his last five outings he is batting .263 with a triple, a home run, a walk and two RBI.
• Anthony Santander is batting .205 with 11 doubles, a triple, seven home runs and 13 walks.

Orioles Team Props

Learn more about this Orioles vs. Cardinals matchup on Fox Sports.

Cardinals Recent Betting Performance

• The Cardinals have played as underdogs in five of their past 10 games and won two of those contests.
• In their last 10 games with a total, the Cardinals and their opponents have combined to hit the over nine times.
• The Cardinals have five wins against the spread in their last 10 chances.

Cardinals Recent Stats

Cardinals Player Insights

• Brendan Donovan is hitting .232 with 11 doubles, a triple, four home runs and 17 walks.
• In all of the majors, Donovan is 139th in homers and 84th in RBI.
• Donovan carries an eight-game hitting streak into this matchup. In his last 10 outings he is hitting .262 with three doubles, six walks and two RBI.
• Nolan Arenado has made the most of his opportunities as he paces his team with 22 RBI.
• Arenado is 171st overall in home runs and 73rd in RBI this season.
• Nootbaar is hitting .213 with seven doubles, five home runs and 22 walks.
• Masyn Winn leads the Cardinals with a .288 batting average.

Cardinals Team Props

Orioles vs. Cardinals Highlights | MLB on FOX

Check out the best moments between the Baltimore Orioles and the St. Louis Cardinals.

FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

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