Orioles vs. Guardians Prediction, Odds, Picks - April 16

Ryan O'Hearn and the Baltimore Orioles will play Jose Ramirez and the Cleveland Guardians at Oriole Park at Camden Yards in the second of a three-game series, on Wednesday at 6:35 p.m. ET. The Orioles are favored in this one, at -126, while the underdog Guardians have +106 odds to upset. Baltimore is favored on the run line (-1.5). The total is 8 runs for the contest (with -109 odds to hit the over and -110 odds on the under).

Take a look at everything you need to know from a betting perspective on the Orioles-Guardians game, regarding the run line, moneyline and total, plus expert picks.

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Orioles vs. Guardians Highlights | MLB on FOX

Check out the top moments from this MLB game between the Cleveland Guardians and the Baltimore Orioles!

Orioles vs. Guardians Game Information & Odds

• When: Wednesday, April 16, 2025 at 6:35 p.m. ET
• Where: Oriole Park at Camden Yards in Baltimore, Maryland
• How to watch on TV: MASN2 and CLEG

Orioles vs. Guardians Prediction

• Score Prediction: Orioles 7, Guardians 6
• Total Prediction: Over 8 runs
• Win Probabilities: Orioles 51%, Guardians 49%

Orioles vs. Guardians Betting Insights

• This season, the Orioles have been favored seven times and won two of those games.
• Baltimore has a record of 1-3 in games when bookmakers favor them by at least -126 on the moneyline.
• The Orioles have a 55.8% chance to win this game based on the implied probability of the moneyline.
• The Guardians have been victorious in three of the eight contests they have been chosen as underdogs in this season.
• This season, Cleveland has come away with a win two times in six chances when named as an underdog of at least +106 or worse on the moneyline.
• Oddsmakers have implied with the moneyline set for this matchup that the Guardians have a 48.5% chance of pulling out a win.

Orioles Recent Betting Performance

• The Orioles have a 1-5 record from the six games they were favored on the moneyline over their last 10 matchups.
• In their last 10 matchups -- all had a set run total -- the Orioles and their opponents combined to go over the total five times.
• The Orioles' record against the spread is 2-8-0 over their past 10 games.

Orioles Recent Stats

Orioles Player Insights

• Cedric Mullins has accumulated a team-high batting average of .300, and paces the Orioles in home runs (four) and runs batted in (17).
• Mullins' home runs put him 26th in the majors, and he is sixth in RBI.
• Adley Rutschman is hitting .237 with two doubles, three home runs and seven walks.
• Among all major league hitters, Rutschman ranks 50th in homers and 139th in RBI.
• Tyler O'Neill is hitting .265 with three doubles, a triple, two home runs and four walks.
• O'Hearn is batting .275 with three doubles, a home run and five walks.
• O'Hearn has recorded at least one hit in two games in a row. In his last five games he is hitting .214 with two walks.

Orioles Team Props

Guardians Recent Betting Performance

• The Guardians have been underdogs twice in the last 10 games and split those matchups 1-1.
• In their last 10 games with a total, the Guardians and their opponents have failed to hit the over six times.
• The Guardians have five wins against the spread in their last 10 chances.

Guardians Recent Stats

Guardians Player Insights

• Steven Kwan has posted a team-leading batting average of .333 while leading the Guardians in runs batted in with a mark of 11.
• Kwan ranks 50th in home runs and 33rd in RBI among all batters in the big leagues.
• Kwan has collected a hit in five straight games. During his last five outings he is batting .391 with two home runs, a walk and eight RBI.
• Ramirez has a team-best four home runs.
• Among all MLB batters, Ramirez ranks 26th in homers and 84th in RBI.
• Kyle Manzardo has been a significant run producer for the Guardians with four home runs and 11 runs batted in.
• Carlos Santana is hitting .246 with two doubles, two home runs and seven walks.

Guardians Team Props

Orioles vs. Guardians Highlights | MLB on FOX

Check out the top moments from this MLB game between the Cleveland Guardians and the Baltimore Orioles!

FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

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Baltimore Orioles

Cleveland Guardians