Orioles vs. Guardians Prediction, Odds, Picks - September 21

Updated Sep. 21, 2023 7:07 p.m. ET

Data Skrive

The Cleveland Guardians will look to Bo Naylor for continued success at the plate when they square off against Gunnar Henderson and the Baltimore Orioles on Thursday, in the first game of a four-game series at Progressive Field. The Guardians have been listed as +136 moneyline underdogs in this matchup against the Orioles (-160). Baltimore is the favorite on the run line (-1.5 with -101 odds). The over/under is 8 runs for this matchup (with -112 odds to go over and -107 odds to go under).

The Baltimore Orioles will give the start to Grayson Rodriguez (6-4, 4.53 ERA), who is looking for win No. 7 on the season, and the Guardians will turn to Hunter Gaddis (2-1, 4.85 ERA).

Here is everything you need from a betting perspective on the Orioles-Guardians game, from the point spread, moneyline, Over/Under and expert picks.

Orioles vs. Guardians Game Information & Odds

When: Thursday, September 21, 2023 at 7:15 PM ET
Where: Progressive Field in Cleveland, Ohio
How to Watch on TV: FOX

Favorite	Favorite Moneyline	Underdog Moneyline	Total	Over Total Odds	Under Total Odds	Run Line	Favorite Run Line Odds	Underdog Run Line Odds
Orioles	-160	+136	8	-112	-107	-1.5	-101	-119

Orioles vs. Guardians Prediction

Score Prediction: Orioles 6, Guardians 5
Total Prediction: Over 8 runs
Win Probabilities: Orioles 52%, Guardians 48%

Orioles vs. Guardians Betting Insights

The Orioles have been favorites in 77 games this season and won 52 (67.5%) of those contests.
Baltimore has entered 31 games this season favored by -160 or more and is 23-8 in those contests.
The moneyline for this contest implies a 61.5% chance of a victory for the Orioles.
The Guardians have been victorious in 35, or 44.9%, of the 78 contests they have been chosen as underdogs in this season.
Cleveland has a mark of 8-15 in contests where bookmakers favor it by +136 or worse on the moneyline.
The moneyline set for this matchup implies the Guardians have a 42.4% chance of walking away with the win.

Orioles Recent Betting Performance

The Orioles have a 2-4 record from the six games they were moneyline favorites over their last 10 matchups.
Over their last 10 outings -- all had a set run total -- the Orioles and their opponents combined to hit the over on the total four times.
The Orioles' record against the spread is 5-5-0 over their past 10 games.

Orioles Recent Stats

Stat	Avg/Total
Record	5-5
Runs Per Game	4.8
HR	12
ERA	3.66
K/9	6.3

Orioles Player Insights

Adley Rutschman is hitting .270 with 27 doubles, a triple, 19 home runs and 85 walks.
Among all hitters in MLB, Rutschman's home run total places him 92nd, and his RBI tally ranks him 60th.
Rutschman has collected a hit in four games in a row. During his last five outings he is hitting .316 with three doubles, a home run, two walks and five RBI.
Henderson has shown his power as he leads his team with 27 home runs.
Henderson is 29th in home runs and 45th in RBI among all major league hitters this season.
Henderson carries a three-game streak with at least one hit into this matchup. During his last five outings he is hitting .333 with a double, a triple, a home run and four RBI.
Anthony Santander leads the Orioles with 27 home runs and 85 runs batted in.
Santander will look to build on his two-game hitting in this game. In his last five games he is batting .211 with two doubles and an RBI.
Austin Hays' .279 batting average leads his team.

Learn more about this Orioles vs. Guardians matchup on Fox Sports.

Guardians Recent Betting Performance

In five games over the last 10 matchups when set as underdogs by bookmakers, the Guardians had a record of 3-2.
In their last 10 games with a total, the Guardians and their opponents have failed to hit the over four times.
The Guardians have a record of 5-5-0 ATS over their last 10 games.

Guardians Recent Stats

Stat	Avg/Total
Record	4-6
Runs Per Game	4.8
HR	9
ERA	3.45
K/9	8.4

Guardians Player Insights

Jose Ramirez has a team- leading batting average of .275, and leads the Guardians in long balls with 24.
Among all batters in the big leagues, Ramirez's home run total ranks 48th and his RBI tally ranks 50th.
Steven Kwan is hitting .275 to lead the lineup.
Kwan is currently 305th in homers and 141st in RBI in the major leagues.
Josh Naylor paces the Guardians with 93 runs batted in.
Andres Gimenez is hitting .247 with 26 doubles, five triples, 13 home runs and 32 walks.