Padres vs. Astros Prediction, Odds, Picks - September 18

Updated Sep. 18, 2024 6:00 p.m. ET

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Dylan Cease gets the start for the San Diego Padres on Wednesday at PETCO Park against Jose Altuve and the Houston Astros. First pitch is at 6:40 p.m. ET. The Astros are +100 moneyline underdogs in this matchup against the favorite Padres (-120). San Diego is the favorite on the run line (-1.5 with +179 odds). The total for the matchup has been set at 7.5 runs.

Here is everything you need to know from a betting perspective on the Padres-Astros game, regarding the run line, moneyline and total, plus expert picks.

Houston Astros vs. Cincinnati Reds Highlights | MLB on FOX

Check out the highlights as the Houston Astros took on the Cincinnati Reds in this regular season matchup.

Padres vs. Astros Game Information & Odds

• When: Wednesday, September 18, 2024 at 6:40 p.m. ET
• Where: PETCO Park in San Diego, California
• How to Watch on TV: SCHN

Padres vs. Astros Prediction

• Score Prediction: Padres 5, Astros 4
• Total Prediction: Over 7.5 runs
• Win Probabilities: Padres 54%, Astros 46%

Padres vs. Astros Betting Insights

• The Padres have entered the game as favorites 98 times this season and won 57, or 58.2%, of those games.
• San Diego is 43-35 this season when entering a game favored by -120 or more on the moneyline.
• The moneyline for this contest implies a 54.5% chance of a victory for the Padres.
• The Astros have come away with 19 wins in the 40 contests they have been listed as the underdogs in this season.
• This season, Houston has been victorious 11 times in 22 chances when named as an underdog of at least +100 or longer on the moneyline.
• The Astros have an implied victory probability of 50% according to the moneyline set for this matchup.

FINAL

HOU 0 · SD 4

MLB

RUN LINE

TO WIN

TOTAL

Houston Astros

HOU

-1.5

-109

O 6.5

San Diego Padres

SD

+1.5

-111

U 6.5

Padres Recent Betting Performance

• The Padres were the moneyline favorite for nine of their last 10 games, and they finished 5-4 in those matchups.
• In their last 10 outings, the Padres and their opponents combined to go over the run total four times (all 10 of the games had set totals).
• The Padres' ATS record is 5-5-0 over their past 10 games.

Padres Recent Stats

Padres Player Insights

• Jurickson Profar is hitting .284 with 27 doubles, 23 home runs and 74 walks.
• Profar's home runs place him 42nd in the majors, and he ranks 33rd in RBI.
• Profar has collected a hit in two games in a row. During his last five outings he is batting .444 with a double, a home run, three walks and an RBI.
• Manny Machado's 27 home runs and 102 RBI both lead his team.
• Machado ranks 26th in homers in MLB, and ninth in RBI.
• Machado carries a two-game streak with at least one hit into this contest. In his last five games he is batting .364 with three doubles, a home run and eight RBI.
• Luis Arraez paces the Padres with a .320 batting average.
• Jackson Merrill is batting .288 with 27 doubles, six triples, 24 home runs and 26 walks.

Padres Team Props

Learn more about this Padres vs. Astros matchup on Fox Sports.

Astros Recent Betting Performance

• Over the past 10 games, the Astros have been underdogs twice and split those games 1-1.
• When it comes to hitting the over, the Astros and their opponents are 5-5-0 in their last 10 games with a total.
• The Astros have six wins against the spread in their last 10 chances.

Astros Recent Stats

Astros Player Insights

• Yordan Alvarez leads the lineup with a batting average of .307, and paces the Astros in home runs, with 34 and runs batted in with 85.
• Among all hitters in the majors, Alvarez is 10th in homers and 29th in RBI.
• Altuve is batting .301 with 29 doubles, 19 home runs and 45 walks.
• Altuve is 77th in home runs and 83rd in RBI among all major league hitters this season.
• Alex Bregman is batting .256 with 28 doubles, two triples, 23 home runs and 42 walks.
• Yainer Diaz is hitting .297 with 26 doubles, three triples, 16 home runs and 23 walks.

Astros Team Props

Houston Astros vs. Cincinnati Reds Highlights | MLB on FOX

Check out the highlights as the Houston Astros took on the Cincinnati Reds in this regular season matchup.

FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

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