Padres vs. Cardinals Prediction, Odds, Picks - September 22

Updated Sep. 22, 2023 9:06 p.m. ET

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Juan Soto and the San Diego Padres take on Richie Palacios and the St. Louis Cardinals at PETCO Park on Friday at 9:40 PM ET, in the first game of a three-game series. Oddsmakers list the Padres as -177 moneyline favorites, while giving the underdog Cardinals +150 moneyline odds. San Diego is favored on the run line (-1.5 with +117 odds). The over/under is 9 runs for the matchup (with -107 odds to go over and -113 odds to go under).

The matchup on the mound for this contest is set with the San Diego Padres looking to Matt Waldron (1-3), and Dakota Hudson (6-2) answering the bell for the St. Louis Cardinals.

Check out everything you need from a betting perspective on the Padres-Cardinals game, from the point spread, moneyline, Over/Under and expert picks.

Padres vs. Cardinals Game Information & Odds

• When: Friday, September 22, 2023 at 9:40 PM ET
• Where: PETCO Park in San Diego, California
• How to Watch on TV: MLB Network

Padres vs. Cardinals Prediction

• Score Prediction: Padres 6, Cardinals 4
• Total Prediction: Over 9 runs
• Win Probabilities: Padres 56%, Cardinals 44%

Padres vs. Cardinals Betting Insights

• This season, the Padres have been favored 113 times and won 62, or 54.9%, of those games.
• San Diego is 23-15 this season when entering a game favored by -177 or more on the moneyline.
• The implied probability of a win from the Padres, based on the moneyline, is 63.9%.
• The Cardinals have been victorious in 32, or 42.7%, of the 75 contests they have been chosen as underdogs in this season.
• St. Louis has a win-loss record of 6-5 when favored by +150 or worse by oddsmakers this year.
• The moneyline set for this matchup implies the Cardinals have a 40% chance of coming away with a victory in the contest.

Padres Recent Betting Performance

• The Padres won each of the six games it played as a moneyline favorite over their last 10 matchups.
• In their last 10 outings, the Padres and their opponents combined to go over the total six times (all 10 games had set totals).
• The Padres have a 7-3-0 record against the spread over their past 10 games.

Padres Recent Stats

Padres Player Insights

• The Padres' best power option comes in the form of Soto and his 32-homer 101-RBI season, both team highs.
• Soto ranks 15th in home runs and ninth in RBI among all hitters in baseball.
• Fernando Tatis Jr. has 32 doubles, a triple, 25 home runs and 50 walks while hitting .262.
• Tatis is 40th in homers and 54th in RBI among all hitters in MLB.
• Xander Bogaerts has racked up a team-best batting average of .283.
• Bogaerts is on a six-game hitting streak entering this contest. In his last 10 outings he is batting .439 with five doubles, a triple, two home runs, three walks and four RBI.
• Manny Machado has 21 doubles, 28 home runs and 49 walks while hitting .248.

Learn more about this Padres vs. Cardinals matchup on Fox Sports.

Cardinals Recent Betting Performance

• In nine games over the last 10 matchups when set as underdogs by sportsbooks, the Cardinals had a record of 4-5.
• The Cardinals and their opponents have combined to hit the over five times in their last 10 games with a total.
• The Cardinals have five wins against the spread in their last 10 chances.

Cardinals Recent Stats

Cardinals Player Insights

• Nolan Arenado has driven in the most runs for the Cardinals with 93 runs batted in.
• Among all hitters in the majors, Arenado's home run total is 34th and his RBI tally is 24th.
• Paul Goldschmidt's .271 batting average is a team-high mark.
• Goldschmidt ranks 40th overall in homers and 48th in RBI this year.
• Willson Contreras is batting .264 with 27 doubles, 20 home runs and 51 walks.
• Lars Nootbaar is batting .265 with 23 doubles, a triple, 13 home runs and 67 walks.

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