Padres vs. Cardinals Prediction, Odds, Picks - September 22

Padres vs. Cardinals Prediction, Odds, Picks - September 22

Updated Sep. 22, 2023 9:06 p.m. ET

Juan Soto and the San Diego Padres take on Richie Palacios and the St. Louis Cardinals at PETCO Park on Friday at 9:40 PM ET, in the first game of a three-game series. Oddsmakers list the Padres as -177 moneyline favorites, while giving the underdog Cardinals +150 moneyline odds. San Diego is favored on the run line (-1.5 with +117 odds). The over/under is 9 runs for the matchup (with -107 odds to go over and -113 odds to go under).

The matchup on the mound for this contest is set with the San Diego Padres looking to Matt Waldron (1-3), and Dakota Hudson (6-2) answering the bell for the St. Louis Cardinals.

Check out everything you need from a betting perspective on the Padres-Cardinals game, from the point spread, moneyline, Over/Under and expert picks.

Padres vs. Cardinals Game Information & Odds

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  • When: Friday, September 22, 2023 at 9:40 PM ET
  • Where: PETCO Park in San Diego, California
  • How to Watch on TV: MLB Network
Favorite Favorite Moneyline Underdog Moneyline Total Over Total Odds Under Total Odds Run Line Favorite Run Line Odds Underdog Run Line Odds
Padres -177 +150 9 -107 -113 -1.5 +117 -140

Padres vs. Cardinals Prediction

  • Score Prediction: Padres 6, Cardinals 4
  • Total Prediction: Over 9 runs
  • Win Probabilities: Padres 56%, Cardinals 44%

Padres vs. Cardinals Betting Insights

  • This season, the Padres have been favored 113 times and won 62, or 54.9%, of those games.
  • San Diego is 23-15 this season when entering a game favored by -177 or more on the moneyline.
  • The implied probability of a win from the Padres, based on the moneyline, is 63.9%.
  • The Cardinals have been victorious in 32, or 42.7%, of the 75 contests they have been chosen as underdogs in this season.
  • St. Louis has a win-loss record of 6-5 when favored by +150 or worse by oddsmakers this year.
  • The moneyline set for this matchup implies the Cardinals have a 40% chance of coming away with a victory in the contest.

Padres Recent Betting Performance

  • The Padres won each of the six games it played as a moneyline favorite over their last 10 matchups.
  • In their last 10 outings, the Padres and their opponents combined to go over the total six times (all 10 games had set totals).
  • The Padres have a 7-3-0 record against the spread over their past 10 games.

Padres Recent Stats

Stat Avg/Total
Record 8-2
Runs Per Game 6
HR 17
ERA 4.60
K/9 10.3

Padres Player Insights

  • The Padres' best power option comes in the form of Soto and his 32-homer 101-RBI season, both team highs.
  • Soto ranks 15th in home runs and ninth in RBI among all hitters in baseball.
  • Fernando Tatis Jr. has 32 doubles, a triple, 25 home runs and 50 walks while hitting .262.
  • Tatis is 40th in homers and 54th in RBI among all hitters in MLB.
  • Xander Bogaerts has racked up a team-best batting average of .283.
  • Bogaerts is on a six-game hitting streak entering this contest. In his last 10 outings he is batting .439 with five doubles, a triple, two home runs, three walks and four RBI.
  • Manny Machado has 21 doubles, 28 home runs and 49 walks while hitting .248.

Learn more about this Padres vs. Cardinals matchup on Fox Sports.

Cardinals Recent Betting Performance

  • In nine games over the last 10 matchups when set as underdogs by sportsbooks, the Cardinals had a record of 4-5.
  • The Cardinals and their opponents have combined to hit the over five times in their last 10 games with a total.
  • The Cardinals have five wins against the spread in their last 10 chances.

Cardinals Recent Stats

Stat Avg/Total
Record 4-6
Runs Per Game 2.8
HR 8
ERA 4.96
K/9 6.7

Cardinals Player Insights

  • Nolan Arenado has driven in the most runs for the Cardinals with 93 runs batted in.
  • Among all hitters in the majors, Arenado's home run total is 34th and his RBI tally is 24th.
  • Paul Goldschmidt's .271 batting average is a team-high mark.
  • Goldschmidt ranks 40th overall in homers and 48th in RBI this year.
  • Willson Contreras is batting .264 with 27 doubles, 20 home runs and 51 walks.
  • Lars Nootbaar is batting .265 with 23 doubles, a triple, 13 home runs and 67 walks.
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