Padres vs. White Sox Prediction, Odds, Picks - September 21

Updated Sep. 21, 2024 8:00 p.m. ET

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Martin Perez takes the mound for the San Diego Padres on Saturday at PETCO Park against Andrew Vaughn and the Chicago White Sox. First pitch is at 8:40 p.m. ET for the second game of a three-game series. The Padres are the favorite in this one, at -300, while the underdog White Sox have +240 odds to play spoiler. San Diego is favored on the run line (-1.5). The over/under is 8 runs for this game (with -113 odds to go over and -107 odds on the under).

Check out everything you need from a betting perspective on the Padres-White Sox game, regarding the run line, moneyline and total, plus expert picks.

White Sox vs. Padres Highlights | MLB on FOX

Check out the greatest plays and moments in this matchup between the Chicago White Sox and the San Diego Padres.

Padres vs. White Sox Game Information & Odds

• When: Saturday, September 21, 2024 at 8:40 p.m. ET
• Where: PETCO Park in San Diego, California
• How to Watch on TV: NBCS-CHI

Padres vs. White Sox Prediction

• Score Prediction: Padres 6, White Sox 3
• Total Prediction: Over 8 runs
• Win Probabilities: Padres 64%, White Sox 36%

Padres vs. White Sox Betting Insights

• This season, the Padres have been favored 100 times and won 59, or 59%, of those games.
• San Diego has not been bigger favorites this season than the -300 moneyline set for this game.
• The moneyline for this contest implies a 75% chance of a victory for the Padres.
• The White Sox have been underdogs in 146 games this season and have come away with the win 32 times (21.9%) in those contests.
• Chicago has a win-loss record of 2-12 when favored by +240 or worse by sportsbooks this year.
• The moneyline set for this matchup implies the White Sox have a 29.4% chance of coming away with a victory in the contest.

FINAL

CWS 2 · SD 6

MLB

RUN LINE

TO WIN

TOTAL

Chicago White Sox

CWS

+1.5

+254

O 8

San Diego Padres

SD

-1.5

-316

U 8

Padres Recent Betting Performance

• The Padres have a 6-3 record over the nine games they were a moneyline favorite in their last 10 matchups.
• Over their last 10 outings (all 10 of them had set totals), the Padres and their opponents combined to hit the over three times.
• The Padres have a 5-5-0 record against the spread over their past 10 games.

Padres Recent Stats

Padres Player Insights

• Jurickson Profar is hitting .283 with 27 doubles, 23 home runs and 74 walks.
• Profar ranks 44th in home runs and 35th in RBI among all batters in baseball.
• Manny Machado's 29 home runs and 104 RBI both pace his team.
• Machado ranks 22nd in home runs in MLB, and eighth in RBI.
• Machado carries a four-game streak with at least one hit into this matchup. During his last five outings he is hitting .350 with a double, three home runs and six RBI.
• Jackson Merrill has 29 doubles, six triples, 24 home runs and 27 walks while hitting .292.
• Merrill is on a two-game hitting streak entering this contest. During his last five outings he is batting .333 with two doubles, a home run, two walks and three RBI.
• Luis Arraez's .318 batting average paces his team.

Padres Team Props

Learn more about this Padres vs. White Sox matchup on Fox Sports.

White Sox Recent Betting Performance

• The White Sox have played as underdogs in 10 of their past 10 games and won three of those contests.
• In their last 10 games with a total, the White Sox and their opponents have failed to hit the over seven times.
• The White Sox have won five of their last 10 games against the spread.

White Sox Recent Stats

White Sox Player Insights

• Vaughn paces the White Sox with 19 home runs and 67 runs batted in, while posting a team-best batting average of .247.
• In all of the big leagues, Vaughn ranks 80th in home runs and 74th in RBI.
• Vaughn carries a six-game hitting streak into this matchup. In his last 10 games he is hitting .333 with two doubles, a triple, two home runs, a walk and five RBI.
• Andrew Benintendi has collected a team-best 19 home runs.
• Among all MLB batters, Benintendi is 80th in home runs and 99th in RBI.
• Gavin Sheets is hitting .236 with 24 doubles, a triple, 10 home runs and 43 walks.
• Nicky Lopez is hitting .243 with 12 doubles, three triples, a home run and 37 walks.

White Sox Team Props

White Sox vs. Padres Highlights | MLB on FOX

Check out the greatest plays and moments in this matchup between the Chicago White Sox and the San Diego Padres.

FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

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