Red Sox vs. White Sox Prediction, Odds, Picks - September 22

Updated Sep. 22, 2023 7:11 p.m. ET

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Chris Sale will start for the Boston Red Sox on Friday against Luis Robert and the Chicago White Sox. First pitch is at 7:10 PM ET at Fenway Park. The Red Sox are -219 moneyline favorites in this matchup against the White Sox (+181). Boston (-1.5) is the favorite on the run line. The contest's over/under has been set at 9 runs.

The Red Sox will start Sale (6-4) against the White Sox and Touki Toussaint (4-7).

Here's everything you need to know from a betting perspective on the Red Sox-White Sox game, from the point spread, moneyline, Over/Under and expert picks.

Red Sox vs. White Sox Game Information & Odds

• When: Friday, September 22, 2023 at 7:10 PM ET
• Where: Fenway Park in Boston, Massachusetts
• How to Watch on TV: NESN

Red Sox vs. White Sox Prediction

• Score Prediction: Red Sox 6, White Sox 4
• Total Prediction: Over 9 runs
• Win Probabilities: Red Sox 57%, White Sox 43%

Red Sox vs. White Sox Betting Insights

• This season, the Red Sox have won 36 out of the 70 games, or 51.4%, in which they've been favored.
• Boston has a record of 5-3 when favored by -219 or more by oddsmakers this season.
• The bookmakers' moneyline implies a 68.7% chance of a victory for the Red Sox.
• The White Sox have been underdogs in 106 games this season and have come away with the win 34 times (32.1%) in those contests.
• Chicago has a mark of 4-4 in contests where oddsmakers favor it by +181 or worse on the moneyline.
• The White Sox have an implied victory probability of 35.6% according to the moneyline set by sportsbooks for this matchup.

Red Sox Recent Betting Performance

• The Red Sox have a 1-2 record across the three games they were a moneyline favorite in their last 10 matchups.
• In their last 10 matchups (all had set totals), the Red Sox combined with their opponents to go over the run total three times.
• The Red Sox's record against the spread is 4-6-0 over their past 10 games.

Red Sox Recent Stats

Red Sox Player Insights

• Rafael Devers is the Red Sox best power hitter, connecting on 33 long balls this season in addition to collecting 98 RBI, both team highs.
• Devers ranks 13th in homers and 13th in RBI among all batters in baseball.
• Justin Turner is hitting .280 with 30 doubles, 23 home runs and 51 walks.
• Turner is 58th in home runs in baseball, and 15th in RBI.
• Masataka Yoshida has put up a team-best batting average of .285.
• Yoshida is on a two-game hitting streak entering this contest. During his last five outings he is hitting .176 with two RBI.
• Alex Verdugo is hitting .266 with 36 doubles, five triples, 13 home runs and 42 walks.
• Verdugo brings a two-game streak with at least one hit into this one. During his last five outings he is batting .111 with .

Learn more about this Red Sox vs. White Sox matchup on Fox Sports.

White Sox Recent Betting Performance

• The White Sox have played as underdogs in seven of their past 10 games and have gone 1-6 in those contests.
• The White Sox and their opponents have combined to hit the over four times in their last 10 games with a total.
• The White Sox have won five of their last 10 games against the spread.

White Sox Recent Stats

White Sox Player Insights

• Robert leads the White Sox with 37 home runs and 79 runs batted in, while recording a team-high batting average of .264.
• Robert ranks seventh in homers and 47th in RBI among all hitters in the majors.
• Andrew Vaughn has 29 doubles, two triples, 20 home runs and 33 walks while batting .262.
• Vaughn is 81st in home runs and 54th in RBI among all hitters in the big leagues.
• Andrew Benintendi has 33 doubles, two triples, five home runs and 51 walks while batting .263.
• Eloy Jimenez is batting .269 with 21 doubles, 17 home runs and 28 walks.

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