Tigers vs. Padres Prediction, Odds, Picks - April 21

The San Diego Padres and Fernando Tatis Jr. take on Kerry Carpenter and the Detroit Tigers on Monday, in the first game of a three-game series at Comerica Park. The Tigers are the favorite in this one, at -143, while the underdog Padres have +120 odds to upset. Detroit is favored on the run line (-1.5). The contest's total has been listed at 8.5 runs.

Here is everything you need to know from a betting perspective on the Tigers-Padres game, regarding the run line, moneyline and total, plus expert picks.

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Tigers vs. Padres Game Information & Odds

• When: Monday, April 21, 2025 at 6:40 p.m. ET
• Where: Comerica Park in Detroit, Michigan
• How to watch on TV: Fox Sports 1, FDSDETX, and SDPA

Tigers vs. Padres Prediction

• Score Prediction: Padres 5, Tigers 4
• Total Prediction: Over 8.5 runs
• Win Probabilities: Tigers 50%, Padres 50%

Tigers vs. Padres Betting Insights

• The Tigers have entered the game as favorites 10 times this season and won seven of those games.
• This season Detroit has won six of its seven games when favored by at least -143 on the moneyline.
• Oddsmakers have implied with the moneyline set for this matchup that the Tigers have a 58.8% chance to win.
• The Padres have been chosen as underdogs in nine games this year and have walked away with the win five times (55.6%) in those games.
• San Diego has a mark of 2-3 in contests where sportsbooks favor it by +120 or worse on the moneyline.
• The Padres have an implied victory probability of 45.5% according to the moneyline set for this matchup.

Tigers Recent Betting Performance

• The Tigers played as the moneyline favorite for five of their last 10 games, and went 3-2 in those matchups.
• In their last 10 outings (all 10 of them had set totals), the Tigers and their opponents combined to go over the run total three times.
• The Tigers have put together a 5-5-0 record against the spread over their past 10 games.

Tigers Recent Stats

Tigers Player Insights

• Spencer Torkelson has gone yard seven times in the 2025 campaign while knocking in 21 runs, both totals that lead the Tigers.
• Torkelson's home runs put him fifth in MLB, and he ranks sixth in RBI.
• Torkelson has collected a hit in five straight games. During his last five outings he is batting .353 with two doubles, two home runs, five walks and nine RBI.
• Carpenter is hitting .315 to pace his team.
• Carpenter ranks 24th in home runs and 64th in RBI on the year.
• Carpenter carries a five-game streak with at least one hit into this contest. In his last five games he is hitting .474 with a double and an RBI.
• Zach McKinstry is batting .288 with a double, two triples, a home run and 13 walks.
• McKinstry is on a three-game hitting streak entering this contest. During his last five outings he is hitting .357 with a double, four walks and three RBI.
• Trey Sweeney is hitting .222 with two doubles, a triple, a home run and six walks.

Tigers Team Props

Padres Recent Betting Performance

• In four games as underdogs over the last 10 matchups, the Padres have a record of 2-2.
• The Padres and their opponents have combined to hit the over three times in their last 10 games with a total.
• The Padres have seven wins against the spread in their last 10 chances.

Padres Recent Stats

Padres Player Insights

• Tatis paces the Padres with eight home runs and 16 runs batted in, while posting a team-best batting average of .358.
• Among all hitters in the big leagues, Tatis' home run total ranks third and his RBI tally ranks 18th.
• Tatis brings a hitting streak of nine games into this matchup. In his last 10 games he is hitting .333 with a triple, six home runs, six walks and nine RBI.
• Manny Machado is batting .305 with nine doubles, two home runs and nine walks.
• Machado is 116th in home runs and 84th in RBI among all MLB hitters this season.
• Xander Bogaerts has eight doubles and 10 walks while hitting .267.
• Gavin Sheets is batting .333 with four doubles, two home runs and five walks.

Padres Team Props

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FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

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Detroit Tigers

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