Tigers vs. Padres Prediction, Odds, Picks - April 22

Spencer Torkelson and the Detroit Tigers square off against Manny Machado and the San Diego Padres on Tuesday at 6:40 p.m. ET, in the second of a three-game series at Comerica Park. The favored Tigers have -134 moneyline odds to win against the underdog Padres, who are listed at +114. Detroit is favored on the run line (-1.5 with +168 odds). The over/under is 7.5 runs for the game.

Here is everything you need from a betting perspective on the Tigers-Padres game, regarding the run line, moneyline and total, plus expert picks.

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Gleyber Torres hits a single, driving in two runs in the Tigers' 6-4 win over Padres

Gleyber Torres hit a single, driving in two runs in the Detroit Tigers' 6-4 win over San Diego Padres.

Tigers vs. Padres Game Information & Odds

• When: Tuesday, April 22, 2025 at 6:40 p.m. ET
• Where: Comerica Park in Detroit, Michigan
• How to watch on TV: FDSDET and SDPA

Tigers vs. Padres Prediction

• Score Prediction: Tigers 6, Padres 5
• Total Prediction: Over 7.5 runs
• Win Probabilities: Tigers 50%, Padres 50%

Tigers vs. Padres Betting Insights

• This season, the Tigers have been favored 11 times and won eight, or 72.7%, of those games.
• This season Detroit has won eight of its nine games, or 88.9%, when favored by at least -134 on the moneyline.
• Oddsmakers have implied with the moneyline set for this matchup that the Tigers have a 57.3% chance to win.
• The Padres have come away with five wins in the 10 contests they have been listed as the underdogs in this season.
• This year, San Diego has won three of seven games when listed as at least +114 or worse on the moneyline.
• Bookmakers have implied with the moneyline set for this matchup that the Padres have a 46.7% chance of pulling out a win.

Tigers Recent Betting Performance

• The Tigers played as the moneyline favorite in six of their last 10 games, and they went 4-2 in those matchups.
• In their last 10 matchups, the Tigers and their opponents combined to go over the total three times (all 10 games had set totals).
• The Tigers' record against the spread is 6-4-0 over their past 10 games.

Tigers Recent Stats

Tigers Player Insights

• Torkelson has accumulated a team-best seven home runs and 21 runs batted in.
• Of all batters in baseball, Torkelson's home run total places him fifth, and his RBI tally ranks him sixth.
• Torkelson takes a hitting streak of six games into this game. In his last 10 games he is batting .278 with two doubles, four home runs, six walks and 14 RBI.
• Zach McKinstry has two doubles, three triples, a home run and 14 walks while hitting .314.
• McKinstry is 173rd in homers and 53rd in RBI on the season.
• McKinstry has four games in a row with at least one hit. In his last five games he is batting .444 with two doubles, a triple, four walks and four RBI.
• Kerry Carpenter paces the Tigers with a .315 batting average.
• Carpenter will look to build on his five-game hitting in this game. In his last five games he is batting .474 with a double and an RBI.
• Trey Sweeney is batting .209 with two doubles, a triple, a home run and six walks.

Tigers Team Props

Padres Recent Betting Performance

• In four games over the last 10 matchups when set as underdogs by bookmakers, the Padres had a record of 1-3.
• In their last 10 games with a total, the Padres and their opponents have failed to hit the over six times.
• The Padres have a record of 6-4-0 ATS over their last 10 games.

Padres Recent Stats

Padres Player Insights

• Fernando Tatis Jr. leads the Padres in home runs (eight), runs batted in (17) and has posted a team-best batting average of .349.
• In all of the big leagues, Tatis is third in homers and 14th in RBI.
• Tatis has collected a hit in 10 straight games. In his last 10 games he is batting .333 with a triple, six home runs, five walks and 10 RBI.
• Machado has nine doubles, two home runs and 10 walks while batting .306.
• Machado ranks 118th in home runs and 90th in RBI among all major league batters this season.
• Gavin Sheets is batting .344 with four doubles, three home runs and five walks.
• Xander Bogaerts is batting .269 with eight doubles and 11 walks.

Padres Team Props

Gleyber Torres hits a single, driving in two runs in the Tigers' 6-4 win over Padres

Gleyber Torres hit a single, driving in two runs in the Detroit Tigers' 6-4 win over San Diego Padres.

FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

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Detroit Tigers

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