Twins vs. Guardians Prediction, Odds, Picks - September 16

Updated Sep. 16, 2024 6:00 p.m. ET

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The Minnesota Twins will look to Carlos Santana for continued offensive production when they take the field against Josh Naylor and the Cleveland Guardians on Monday. The Twins have been listed as -118 moneyline favorites in this matchup against the Guardians (-102). Minnesota is the favorite on the run line (-1.5). The over/under is 7.5 runs for this matchup (with -102 odds on the over and -117 odds to go under).

Check out everything you need from a betting perspective on the Twins-Guardians game, regarding the run line, moneyline and total, plus expert picks.

Reds vs. Twins Highlights | MLB on FOX

Check out the best moments between the Cincinnati Reds and the Minnesota Twins.

Twins vs. Guardians Game Information & Odds

• When: Monday, September 16, 2024 at 6:40 p.m. ET
• Where: Progressive Field in Cleveland, Ohio
• How to Watch on TV: BSGL

Twins vs. Guardians Prediction

• Score Prediction: Guardians 4, Twins 3
• Total Prediction: Under 7.5 runs
• Win Probabilities: Twins 54%, Guardians 46%

Twins vs. Guardians Betting Insights

• The Twins have won 61, or 59.8%, of the 102 games they've played as favorites this season.
• This season Minnesota has won 55 of its 94 games, or 58.5%, when favored by at least -118 on the moneyline.
• The implied probability of a win from the Twins, based on the moneyline, is 54.1%.
• The Guardians have been underdogs in 54 games this season and have come away with the win 24 times (44.4%) in those contests.
• Cleveland has a mark of 19-29 in contests where oddsmakers favor it by -102 or worse on the moneyline.
• The moneyline set for this matchup implies the Guardians have a 50.5% chance of coming away with a victory in the contest.

FINAL

MIN 3 · CLE 4

MLB

RUN LINE

TO WIN

TOTAL

Minnesota Twins

MIN

-1.5

-118

O 7.5

Cleveland Guardians

CLE

+1.5

-101

U 7.5

Twins Recent Betting Performance

• The Twins went 4-4 over the eight games they were favored on the moneyline in their last 10 matchups.
• In their last 10 outings (all had set totals), the Twins combined with their opponents to hit the over on the run total five times.
• The Twins have a 3-7-0 record against the spread over their past 10 games.

Twins Recent Stats

Twins Player Insights

• Santana has racked up a team-high 22 home runs and 65 runs batted in.
• Of all hitters in MLB, Santana's home run total ranks him 44th, and his RBI tally ranks him 72nd.
• Santana carries a five-game hitting streak into this matchup. In his last five games he is hitting .444 with a double, two home runs, two walks and five RBI.
• Willi Castro is hitting .249 to pace his team.
• Castro ranks 178th in homers in the majors, and 119th in RBI.
• Castro carries a four-game streak with at least one hit into this matchup. In his last five games he is batting .286 with a walk and three RBI.
• Ryan Jeffers is batting .232 with 22 doubles, 20 home runs and 30 walks.
• Jose Miranda is hitting .292 with 28 doubles, four triples, nine home runs and 18 walks.

Twins Team Props

Learn more about this Twins vs. Guardians matchup on Fox Sports.

Guardians Recent Betting Performance

• In three games as underdogs over the last 10 matchups, the Guardians have a record of 1-2.
• When it comes to hitting the over, the Guardians and their opponents are 2-8-0 in their last 10 games with a total.
• Over their last 10 games, the Guardians are 6-4-0 against the spread.

Guardians Recent Stats

Guardians Player Insights

• Jose Ramirez paces the Guardians in home runs (35) and runs batted in (107).
• Among all hitters in MLB, Ramirez's home run total ranks eighth and his RBI tally is third.
• Ramirez takes a hitting streak of eight games into this game. In his last 10 games he is batting .256 with three doubles, a home run, five walks and an RBI.
• Naylor has 25 doubles, 29 home runs and 55 walks while batting .245.
• Naylor is currently 19th in home runs and sixth in RBI in the major leagues.
• Steven Kwan has a team-high batting average of .291.
• Andres Gimenez has 20 doubles, a triple, eight home runs and 25 walks while batting .251.

Guardians Team Props

Reds vs. Twins Highlights | MLB on FOX

Check out the best moments between the Cincinnati Reds and the Minnesota Twins.

FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

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