The Week 15 NFL schedule has plenty of exciting matchups on the docket. Among those contests is the Buffalo Bills playing the Detroit Lions.

To pick up an edge before Week 15 in the NFL, check out our betting preview below.

Check out the full NFL football schedule on FOX Sports!

Week 15 Betting Lines & Game Info

San Francisco 49ers vs. Los Angeles Rams

Odds & Prediction

• Spread: 49ers (-3)
• Moneyline: 49ers -155, Rams +131
• Total: 48.5 points
• Prediction: 49ers 25, Rams 23

How to Watch

• Game Date: Thursday, Dec. 12
• Game Time: 8:15 p.m. ET
• TV Channel: Amazon Prime Video
• Location: Santa Clara, California

Cleveland Browns vs. Kansas City Chiefs

Odds & Prediction

• Spread: Chiefs (-4)
• Moneyline: Chiefs -230, Browns +190
• Total: 41 points
• Prediction: Chiefs 28, Browns 15

How to Watch

• Game Date: Sunday, Dec. 15
• Game Time: 1 p.m. ET
• TV Channel: CBS
• Location: Cleveland, Ohio

New Orleans Saints vs. Washington Commanders

Odds & Prediction

• Spread: Commanders (-7.5)
• Moneyline: Commanders -386, Saints +304
• Total: 44.5 points
• Prediction: Commanders 26, Saints 22

How to Watch

• Game Date: Sunday, Dec. 15
• Game Time: 1 p.m. ET
• TV Channel: Watch Online: FOX
• Location: New Orleans, Louisiana

New York Giants vs. Baltimore Ravens

Odds & Prediction

• Spread: Ravens (-17)
• Moneyline: Ravens -1786, Giants +978
• Total: 43.5 points
• Prediction: Ravens 30, Giants 16

How to Watch

• Game Date: Sunday, Dec. 15
• Game Time: 1 p.m. ET
• TV Channel: CBS
• Location: East Rutherford, New Jersey

Jacksonville Jaguars vs. New York Jets

Odds & Prediction

• Spread: Jets (-3.5)
• Moneyline: Jets -176, Jaguars +148
• Total: 41.5 points
• Prediction: Jaguars 23, Jets 21

How to Watch

• Game Date: Sunday, Dec. 15
• Game Time: 1 p.m. ET
• TV Channel: Watch Online: FOX
• Location: Jacksonville, Florida

Carolina Panthers vs. Dallas Cowboys

Odds & Prediction

• Spread: Panthers (-2.5)
• Moneyline: Panthers -141, Cowboys +120
• Total: 42 points
• Prediction: Cowboys 25, Panthers 23

How to Watch

• Game Date: Sunday, Dec. 15
• Game Time: 1 p.m. ET
• TV Channel: Watch Online: FOX
• Location: Charlotte, North Carolina

Tennessee Titans vs. Cincinnati Bengals

Odds & Prediction

• Spread: Bengals (-5.5)
• Moneyline: Bengals -260, Titans +211
• Total: 46 points
• Prediction: Bengals 26, Titans 24

How to Watch

• Game Date: Sunday, Dec. 15
• Game Time: 1 p.m. ET
• TV Channel: Watch Online: FOX
• Location: Nashville, Tennessee

Houston Texans vs. Miami Dolphins

Odds & Prediction

• Spread: Texans (-2.5)
• Moneyline: Texans -154, Dolphins +129
• Total: 46.5 points
• Prediction: Texans 27, Dolphins 17

How to Watch

• Game Date: Sunday, Dec. 15
• Game Time: 1 p.m. ET
• TV Channel: CBS
• Location: Houston, Texas

Arizona Cardinals vs. New England Patriots

Odds & Prediction

• Spread: Cardinals (-6)
• Moneyline: Cardinals -266, Patriots +215
• Total: 46.5 points
• Prediction: Cardinals 29, Patriots 13

How to Watch

• Game Date: Sunday, Dec. 15
• Game Time: 4:25 p.m. ET
• TV Channel: CBS
• Location: Glendale, Arizona

Philadelphia Eagles vs. Pittsburgh Steelers

Odds & Prediction

• Spread: Eagles (-5.5)
• Moneyline: Eagles -258, Steelers +209
• Total: 43 points
• Prediction: Eagles 26, Steelers 18

How to Watch

• Game Date: Sunday, Dec. 15
• Game Time: 4:25 p.m. ET
• TV Channel: Watch Online: FOX
• Location: Philadelphia, Pennsylvania

Detroit Lions vs. Buffalo Bills

Odds & Prediction

• Spread: Lions (-2.5)
• Moneyline: Lions -141, Bills +119
• Total: 55.5 points
• Prediction: Lions 30, Bills 21

How to Watch

• Game Date: Sunday, Dec. 15
• Game Time: 4:25 p.m. ET
• TV Channel: CBS
• Location: Detroit, Michigan

Los Angeles Chargers vs. Tampa Bay Buccaneers

Odds & Prediction

• Spread: Chargers (-3)
• Moneyline: Chargers -160, Buccaneers +135
• Total: 45.5 points
• Prediction: Chargers 23, Buccaneers 22

How to Watch

• Game Date: Sunday, Dec. 15
• Game Time: 4:25 p.m. ET
• TV Channel: Watch Online: FOX
• Location: Inglewood, California

Denver Broncos vs. Indianapolis Colts

Odds & Prediction

• Spread: Broncos (-4.5)
• Moneyline: Broncos -228, Colts +187
• Total: 43.5 points
• Prediction: Broncos 25, Colts 17

How to Watch

• Game Date: Sunday, Dec. 15
• Game Time: 4:25 p.m. ET
• TV Channel: CBS
• Location: Denver, Colorado

Seattle Seahawks vs. Green Bay Packers

Odds & Prediction

• Spread: Packers (-3)
• Moneyline: Packers -152, Seahawks +128
• Total: 47.5 points
• Prediction: Packers 24, Seahawks 22

How to Watch

• Game Date: Sunday, Dec. 15
• Game Time: 8:20 p.m. ET
• TV Channel: NBC
• Location: Seattle, Washington

Minnesota Vikings vs. Chicago Bears

Odds & Prediction

• Spread: Vikings (-7)
• Moneyline: Vikings -336, Bears +268
• Total: 43.5 points
• Prediction: Vikings 30, Bears 13

How to Watch

• Game Date: Monday, Dec. 16
• Game Time: 8 p.m. ET
• TV Channel: ABC
• Location: Minneapolis, Minnesota

Las Vegas Raiders vs. Atlanta Falcons

Odds & Prediction

• Spread: Falcons (-6)
• Moneyline: Falcons -288, Raiders +234
• Total: 44.5 points
• Prediction: Falcons 25, Raiders 22

How to Watch

• Game Date: Monday, Dec. 16
• Game Time: 8:30 p.m. ET
• TV Channel: ESPN
• Location: Paradise, Nevada

Learn more about today's games on FOX Sports.

FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

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