In one of the many compelling matchups on the NFL slate in Week 2, the New Orleans Saints and the Dallas Cowboys square off at AT&T Stadium.

Read through our betting preview for the NFL's Week 2.

Check out the full NFL football schedule on FOX Sports!

Week 2 Betting Lines & Game Info

Miami Dolphins vs. Buffalo Bills

Odds & Prediction

• Spread: Dolphins (-2.5)
• Moneyline: Dolphins -137, Bills +116
• Total: 48.5 points
• Prediction: Bills 26, Dolphins 25

How to Watch

• Game Date: Thursday, Sept. 12
• Game Time: 8:15 PM ET
• TV Channel: Amazon Prime Video
• Location: Miami Gardens, Florida

Dallas Cowboys vs. New Orleans Saints

Odds & Prediction

• Spread: Cowboys (-6.5)
• Moneyline: Cowboys -294, Saints +238
• Total: 47 points
• Prediction: Cowboys 34, Saints 19

How to Watch

• Game Date: Sunday, Sept. 15
• Game Time: 1:00 PM ET
• TV Channel: Watch Online: FOX
• Location: Arlington, Texas

Detroit Lions vs. Tampa Bay Buccaneers

Odds & Prediction

• Spread: Lions (-7.5)
• Moneyline: Lions -375, Buccaneers +297
• Total: 51.5 points
• Prediction: Lions 28, Buccaneers 23

How to Watch

• Game Date: Sunday, Sept. 15
• Game Time: 1:00 PM ET
• TV Channel: Watch Online: FOX
• Location: Detroit, Michigan

Minnesota Vikings vs. San Francisco 49ers

Odds & Prediction

• Spread: 49ers (-4.5)
• Moneyline: 49ers -211, Vikings +175
• Total: 46.5 points
• Prediction: Vikings 26, 49ers 17

How to Watch

• Game Date: Sunday, Sept. 15
• Game Time: 1:00 PM ET
• TV Channel: CBS
• Location: Minneapolis, Minnesota

New England Patriots vs. Seattle Seahawks

Odds & Prediction

• Spread: Seahawks (-3)
• Moneyline: Seahawks -168, Patriots +142
• Total: 39 points
• Prediction: Patriots 20, Seahawks 16

How to Watch

• Game Date: Sunday, Sept. 15
• Game Time: 1:00 PM ET
• TV Channel: Watch Online: FOX
• Location: Foxborough, Massachusetts

Washington Commanders vs. New York Giants

Odds & Prediction

• Spread: Commanders (-1.5)
• Moneyline: Commanders -124, Giants +104
• Total: 43 points
• Prediction: Giants 26, Commanders 19

How to Watch

• Game Date: Sunday, Sept. 15
• Game Time: 1:00 PM ET
• TV Channel: Watch Online: FOX
• Location: Landover, Maryland

Jacksonville Jaguars vs. Cleveland Browns

Odds & Prediction

• Spread: Jaguars (-3)
• Moneyline: Jaguars -169, Browns +142
• Total: 41 points
• Prediction: Browns 26, Jaguars 17

How to Watch

• Game Date: Sunday, Sept. 15
• Game Time: 1:00 PM ET
• TV Channel: CBS
• Location: Jacksonville, Florida

Green Bay Packers vs. Indianapolis Colts

Odds & Prediction

• Spread: Colts (-2.5)
• Moneyline: Colts -139, Packers +118
• Total: 41.5 points
• Prediction: Packers 31, Colts 29

How to Watch

• Game Date: Sunday, Sept. 15
• Game Time: 1:00 PM ET
• TV Channel: Watch Online: FOX
• Location: Green Bay, Wisconsin

Tennessee Titans vs. New York Jets

Odds & Prediction

• Spread: Jets (-4)
• Moneyline: Jets -189, Titans +158
• Total: 41.5 points
• Prediction: Titans 26, Jets 20

How to Watch

• Game Date: Sunday, Sept. 15
• Game Time: 1:00 PM ET
• TV Channel: CBS
• Location: Nashville, Tennessee

Carolina Panthers vs. Los Angeles Chargers

Odds & Prediction

• Spread: Chargers (-4.5)
• Moneyline: Chargers -223, Panthers +183
• Total: 38.5 points
• Prediction: Chargers 29, Panthers 15

How to Watch

• Game Date: Sunday, Sept. 15
• Game Time: 1:00 PM ET
• TV Channel: CBS
• Location: Charlotte, North Carolina

Baltimore Ravens vs. Las Vegas Raiders

Odds & Prediction

• Spread: Ravens (-8.5)
• Moneyline: Ravens -444, Raiders +343
• Total: 41.5 points
• Prediction: Ravens 25, Raiders 14

How to Watch

• Game Date: Sunday, Sept. 15
• Game Time: 1:00 PM ET
• TV Channel: CBS
• Location: Baltimore, Maryland

Arizona Cardinals vs. Los Angeles Rams

Odds & Prediction

• Spread: Rams (-1)
• Moneyline: Rams -111, Cardinals -108
• Total: 47.5 points
• Prediction: Rams 32, Cardinals 22

How to Watch

• Game Date: Sunday, Sept. 15
• Game Time: 4:05 PM ET
• TV Channel: Watch Online: FOX
• Location: Glendale, Arizona

Kansas City Chiefs vs. Cincinnati Bengals

Odds & Prediction

• Spread: Chiefs (-6.5)
• Moneyline: Chiefs -295, Bengals +238
• Total: 47.5 points
• Prediction: Chiefs 28, Bengals 8

How to Watch

• Game Date: Sunday, Sept. 15
• Game Time: 4:25 PM ET
• TV Channel: CBS
• Location: Kansas City, Missouri

Denver Broncos vs. Pittsburgh Steelers

Odds & Prediction

• Spread: Steelers (-2.5)
• Moneyline: Steelers -148, Broncos +125
• Total: 36.5 points
• Prediction: Steelers 22, Broncos 15

How to Watch

• Game Date: Sunday, Sept. 15
• Game Time: 4:25 PM ET
• TV Channel: CBS
• Location: Denver, Colorado

Houston Texans vs. Chicago Bears

Odds & Prediction

• Spread: Texans (-6)
• Moneyline: Texans -274, Bears +221
• Total: 45 points
• Prediction: Texans 35, Bears 13

How to Watch

• Game Date: Sunday, Sept. 15
• Game Time: 8:20 PM ET
• TV Channel: NBC
• Location: Houston, Texas

Philadelphia Eagles vs. Atlanta Falcons

Odds & Prediction

• Spread: Eagles (-5.5)
• Moneyline: Eagles -249, Falcons +203
• Total: 45.5 points
• Prediction: Falcons 27, Eagles 19

How to Watch

• Game Date: Monday, Sept. 16
• Game Time: 8:15 PM ET
• TV Channel: ESPN
• Location: Philadelphia, Pennsylvania

Learn more about today's games on FOX Sports.

FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

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