The Tampa Bay Buccaneers versus the New Orleans Saints is a game to catch on a Week 6 NFL slate that includes plenty of compelling matchups.

To gain an edge ahead of Week 6 in the NFL, read our betting preview below.

Check out the full NFL football schedule on FOX Sports!

Week 6 Betting Lines & Game Info

Seattle Seahawks vs. San Francisco 49ers

Odds & Prediction

• Spread: 49ers (-3.5)
• Moneyline: 49ers -181, Seahawks +151
• Total: 47.5 points
• Prediction: Seahawks 24, 49ers 23

How to Watch

• Game Date: Thursday, Oct. 10
• Game Time: 8:15 p.m. ET
• TV Channel: Amazon Prime Video
• Location: Seattle, Washington

Chicago Bears vs. Jacksonville Jaguars

Odds & Prediction

• Spread: Bears (-2.5)
• Moneyline: Bears -135, Jaguars +114
• Total: 44.5 points
• Prediction: Bears 29, Jaguars 15

How to Watch

• Game Date: Sunday, Oct. 13
• Game Time: 9:30 a.m. ET
• TV Channel: NFL Network
• Location: London, England

New England Patriots vs. Houston Texans

Odds & Prediction

• Spread: Texans (-7)
• Moneyline: Texans -313, Patriots +249
• Total: 37.5 points
• Prediction: Texans 24, Patriots 14

How to Watch

• Game Date: Sunday, Oct. 13
• Game Time: 1:00 p.m. ET
• TV Channel: CBS
• Location: Foxborough, Massachusetts

Tennessee Titans vs. Indianapolis Colts

Odds & Prediction

• Spread: Colts (-1)
• Moneyline: Colts -114, Titans -106
• Total: 43.5 points
• Prediction: Colts 23, Titans 22

How to Watch

• Game Date: Sunday, Oct. 13
• Game Time: 1:00 p.m. ET
• TV Channel: CBS
• Location: Nashville, Tennessee

Green Bay Packers vs. Arizona Cardinals

Odds & Prediction

• Spread: Packers (-5.5)
• Moneyline: Packers -242, Cardinals +195
• Total: 49.5 points
• Prediction: Packers 29, Cardinals 19

How to Watch

• Game Date: Sunday, Oct. 13
• Game Time: 1:00 p.m. ET
• TV Channel: Watch Online: FOX
• Location: Green Bay, Wisconsin

New Orleans Saints vs. Tampa Bay Buccaneers

Odds & Prediction

• Spread: Buccaneers (-1.5)
• Moneyline: Buccaneers -118, Saints +103
• Total: 42.5 points
• Prediction: Saints 25, Buccaneers 24

How to Watch

• Game Date: Sunday, Oct. 13
• Game Time: 1:00 p.m. ET
• TV Channel: Watch Online: FOX
• Location: New Orleans, Louisiana

Baltimore Ravens vs. Washington Commanders

Odds & Prediction

• Spread: Ravens (-6.5)
• Moneyline: Ravens -291, Commanders +236
• Total: 52.5 points
• Prediction: Commanders 28, Ravens 27

How to Watch

• Game Date: Sunday, Oct. 13
• Game Time: 1:00 p.m. ET
• TV Channel: CBS
• Location: Baltimore, Maryland

Philadelphia Eagles vs. Cleveland Browns

Odds & Prediction

• Spread: Eagles (-8.5)
• Moneyline: Eagles -441, Browns +343
• Total: 43.5 points
• Prediction: Eagles 31, Browns 11

How to Watch

• Game Date: Sunday, Oct. 13
• Game Time: 1:00 p.m. ET
• TV Channel: Watch Online: FOX
• Location: Philadelphia, Pennsylvania

Denver Broncos vs. Los Angeles Chargers

Odds & Prediction

• Spread: Chargers (-3)
• Moneyline: Chargers -159, Broncos +135
• Total: 35.5 points
• Prediction: Broncos 19, Chargers 13

How to Watch

• Game Date: Sunday, Oct. 13
• Game Time: 4:05 p.m. ET
• TV Channel: CBS
• Location: Denver, Colorado

Las Vegas Raiders vs. Pittsburgh Steelers

Odds & Prediction

• Spread: Steelers (-3)
• Moneyline: Steelers -157, Raiders +132
• Total: 36.5 points
• Prediction: Steelers 24, Raiders 15

How to Watch

• Game Date: Sunday, Oct. 13
• Game Time: 4:05 p.m. ET
• TV Channel: CBS
• Location: Paradise, Nevada

Carolina Panthers vs. Atlanta Falcons

Odds & Prediction

• Spread: Falcons (-6)
• Moneyline: Falcons -272, Panthers +219
• Total: 47.5 points
• Prediction: Falcons 32, Panthers 15

How to Watch

• Game Date: Sunday, Oct. 13
• Game Time: 4:25 p.m. ET
• TV Channel: Watch Online: FOX
• Location: Charlotte, North Carolina

Dallas Cowboys vs. Detroit Lions

Odds & Prediction

• Spread: Lions (-3)
• Moneyline: Lions -171, Cowboys +144
• Total: 52.5 points
• Prediction: Cowboys 25, Lions 22

How to Watch

• Game Date: Sunday, Oct. 13
• Game Time: 4:25 p.m. ET
• TV Channel: Watch Online: FOX
• Location: Arlington, Texas

New York Giants vs. Cincinnati Bengals

Odds & Prediction

• Spread: Bengals (-3.5)
• Moneyline: Bengals -177, Giants +147
• Total: 48.5 points
• Prediction: Giants 27, Bengals 21

How to Watch

• Game Date: Sunday, Oct. 13
• Game Time: 8:20 p.m. ET
• TV Channel: NBC
• Location: East Rutherford, New Jersey

New York Jets vs. Buffalo Bills

Odds & Prediction

• Spread: Bills (-2.5)
• Moneyline: Bills -142, Jets +121
• Total: 41 points
• Prediction: Jets 23, Bills 20

How to Watch

• Game Date: Monday, Oct. 14
• Game Time: 8:15 p.m. ET
• TV Channel: ESPN
• Location: East Rutherford, New Jersey

Learn more about today's games on FOX Sports.

FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

---