2025-26 San Francisco 49ers Odds: Odds to win Super Bowl, NFL Playoffs, Division

The San Francisco 49ers right now have the eighth-ranked odds in the league to win the Super Bowl at +1300.

The 49ers took on the Indianapolis Colts in their last game, winning 48-27. Brock Purdy led the Niners with 295 yards on 25-of-34 passing (73.5%) for five touchdowns and one interception. Christian McCaffrey carried the ball 21 times for 117 yards (5.6 yards per carry). He also had six receptions for 29 yards and two touchdowns. George Kittle recorded seven receptions for 115 yards (averaging 16.4 per catch), while scoring one touchdown.

49ers Postseason Odds

• Odds to win the NFC West: +215 (Bet $100 to win $215)
• Odds to win the Super Bowl: +1300 (Bet $100 to win $1,300)

Learn more about the San Francisco 49ers on Fox Sports.

49ers Super Bowl Odds Insights

• The 49ers own +1300 odds to win the Super Bowl, which ranks eighth-best in the league. As a comparison, our computer rankings have them ranked better at fifth-best, a difference of three spots.
• The 49ers sport better Super Bowl odds now (+1300) than they did before the season (+1900). Their improved odds represent the fifth-smallest change among all teams this year.
• The 49ers sport a 7.1% chance of winning the Super Bowl, based on their current odds (+1300).

49ers Betting Insights

• The 49ers have compiled a 10-5-0 ATS record this year.
• San Francisco and its opponent have combined to hit the over nine out of 15 times this season.
• The 49ers have been favored on the moneyline 11 total times this season. They've gone 10-1 in those games.
• This season, San Francisco has won one out of the four games in which it has been the underdog.

49ers Top Players

• Mac Jones has 2,151 passing yards (195.5 per game) and a 69.6% completion percentage (201-for-289), pitching 13 touchdown passes and six interceptions.
• McCaffrey has run for a team-high 1,039 yards (69.3 per game) and scored nine touchdowns. Receiving, he has reeled in 92 passes for 849 yards and seven touchdowns.
• McCaffrey's status for Sunday is unknown.
• Brian Robinson Jr. has 369 rushing yards on 86 attempts, and two touchdowns.
• Kittle has chipped in with 52 receptions (on 62 targets) for 599 yards, scoring seven touchdowns.
• Kittle's status for Sunday is currently unknown.
• Jauan Jennings is averaging 43.5 yards per game, with 49 catches for 566 yards and eight touchdowns.
• This season Bryce Huff leads the team with 4.0 sacks and has added 6.0 TFL and 27 tackles.
• Dee Winters has totaled 92 tackles, 7.0 TFL, and one interception, and he's tops on his team in tackles.
• This season Ji'Ayir Brown leads the team with two interceptions and has added 51 tackles, 2.0 TFL, and five passes defended.

49ers 2025-26 Schedule

FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

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San Francisco 49ers