49ers vs. Cardinals 2024 Prediction, Odds, Picks - Oct 6

Updated Oct. 6, 2024 12:43 p.m. ET

Data Skrive

The San Francisco 49ers (2-2) are solid favorites -- expected to win by at least a touchdown (currently -7.5) -- versus the Arizona Cardinals (1-3) in a battle of two division rivals. The total for this one is set at 49 points.

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49ers vs. Cardinals Odds & Betting Lines

49ers vs Cardinals Betting Information updated as of October 6, 2024, 12:33 p.m. ET.
Favorite	Spread	Favorite Spread Odds	Underdog Spread Odds	Total	Over Total Odds	Under Total Odds
49ers	-7.5	-104	-117	49	-108	-112

49ers vs. Cardinals Prediction & Pick

Pick ATS: 49ers (-7.5)
Pick OU: Under (49)
Prediction: 49ers 31 - Cardinals 18

How to Watch San Francisco vs. Arizona

Game Date: Sunday, October 6, 2024
Time: 4:05 p.m. ET
Venue: Levi's Stadium
Location: Santa Clara, California
TV: Watch on FOX
Live Boxscore: FOX Sports

49ers vs. Cardinals Recent Matchups

In their last five head-to-head contests, San Francisco has taken down Arizona four times.
In their last five head-to-head matchups, San Francisco has scored 173 points versus Arizona, while surrendering only 99 points.

San Francisco Betting Info

San Francisco has two wins versus the spread in four games this season.
The 49ers have won their only game this season when playing as at least 7.5-point favorites.
San Francisco games this year have hit the over on three of four set point totals (75%).
When playing as moneyline favorites, the 49ers are 2-2 (winning 50% of the time).
The 49ers have an implied win probability, based on the moneyline, of 77.5%.

49ers Stats

Stat	Average (Total)	Rank
Pass yards	271.5 (1,086)	2
Rush yards	141.8 (567)	8
Points scored	25.8 (103)	10
Pass yards against	199 (796)	15
Rush yards against	96.3 (385)	6
Points allowed	20.5 (82)	9

San Francisco's Key Players

Offense

Jordan Mason's rushing stat line this season includes 447 yards (second in the NFL) and three TDs. He's averaging 111.8 yards per game and 4.9 per attempt (14th in the NFL).
He has caught six passes (on seven targets) for 57 receiving yards with zero touchdowns. He's averaging 14.3 receving yards and 1.5 catches per game.
Brock Purdy has thrown for 1,130 yards (fourth in the NFL), five touchdowns and two interceptions this year. He averages 282.5 yards per game and 9.3 per attempt, while completing 68.9%.
He has also rushed for 75 yards (second on the 49ers) without scoring a touchdown on the ground, while averaging 18.8 rushing yards per game.
Jauan Jennings has three touchdown catches this season (fourth in the NFL), and has 21 catches for 364 yards (fifth in the NFL) on 27 targets, while averaging 5.3 catches and 91 yards per game.
Deebo Samuel has 16 catches for 222 yards and zero touchdowns. He's been targeted 24 times in the passing game, and averages 5.3 receptions and 74 yards in three games played.

Defense

On the defensive side, Fred Warner has one sack (fourth on the 49ers) to go with one TFL, 27 tackles, and two interceptions in 2024.
Nick Bosa has 14 tackles, four TFL, and three sacks this season.
Maliek Collins has collected 10 tackles, two TFL, and 2.5 sacks.
So far this season, Ji'Ayir Brown has 20 tackles and two TFL. He's third on the 49ers in tackles.

Arizona Betting Info

Arizona has covered the spread two times in four games with a set number.
Arizona games have gone over the total three times this season.
The Cardinals have lost both games they've played as underdogs this season.
Sportsbooks have implied with the moneyline set for this matchup that the Cardinals have a 26.7% chance to win.

Cardinals Stats

Stat	Average (Total)	Rank
Pass yards	179.8 (719)	25
Rush yards	153.3 (613)	5
Points scored	24 (96)	14
Pass yards against	208.3 (833)	17
Rush yards against	146.5 (586)	27
Points allowed	26.5 (106)	29

Arizona's Key Players

Offense

Kyler Murray has thrown for 777 yards this year, with six touchdowns (sixth in the NFL) and one interception. He is completing 69.4% of his passes while averaging 194.3 yards per game and 7.2 per attempt.
He's added 164 yards on the ground (second on the Cardinals), with zero rushing touchdowns. He's averaging 41 yards per game and 10.3 per attempt.
James Conner averages 73.3 rushing yards per game through four games (293 total yards), while scoring three rushing touchdowns.
Conner also has six catches for 52 yards (sixth on the Cardinals). He has been targeted seven times and averages 13 yards per game.
In four games played this season, Marvin Harrison Jr. has 15 catches (3.8 receptions per game on seven targets per game) for 243 yards and four receiving touchdowns (second in the NFL).
Michael Wilson has 14 catches for 138 yards and one receiving touchdown. He averages 3.5 yards per game through four games and has been targeted 20 times.

Defense

Budda Baker's 2024 output includes 39 tackles and three TFL in four games. He leads the Cardinals in tackles.
Dennis Gardeck's stat sheet includes one interception as well as 14 tackles, five TFL, three sacks, and one pass defended.
Mack Wilson has one sack (second on the Cardinals) in addition to his two TFL and 27 tackles.
Kyzir White's stat sheet includes 38 tackles and one TFL in four games

FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

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