49ers vs. Cardinals Prediction, Odds, Picks - Dec 17

Updated Dec. 13, 2023 1:16 p.m. ET

Data Skrive

Having won five in a row, the San Francisco 49ers (10-3) will play the Arizona Cardinals (3-10). The 49ers are big favorites (-13.5). The predicted point total for the game is 48.

49ers vs. Cardinals Odds & Betting Lines

49ers vs Cardinals Betting Information updated as of December 12, 2023, 4:34 PM ET.
Favorite	Spread	Favorite Spread Odds	Underdog Spread Odds	Total	Over Total Odds	Under Total Odds
49ers	-13.5	-110	-110	48	-110	-110

49ers vs. Cardinals Prediction & Pick

Pick ATS: San Francisco (-13.5)
Pick OU: Under (48)
Prediction: San Francisco 31 - Arizona 13

How to Watch San Francisco vs. Arizona

Game Date: Sunday, December 17, 2023
Time: 4:05 PM ET
Venue: State Farm Stadium
Location: Glendale, Arizona
TV: Watch on CBS

49ers vs. Cardinals Recent Matchups

In their last five head-to-head bouts, San Francisco has taken down Arizona five times.
Over their last five head-to-head contests, San Francisco has racked up 175 points, while Arizona has accumulated 90.

San Francisco Betting Info

San Francisco has played 13 games, posting seven wins against the spread.
The 49ers have covered the spread once this season (1-2 ATS) when playing as at least 13.5-point favorites.
San Francisco games this year have gone over the total in six out of 13 opportunities (46.2%).
The 49ers have compiled a 10-3 record in games they played as moneyline favorite (winning 76.9% of those games).
San Francisco has played as a moneyline favorite of -1000 or shorter in just two games this season, and it won both.
The 49ers have an implied win probability, based on the moneyline, of 90.9%.

49ers Stats

Stat	Average (Total)	Rank
Pass yards	262.7 (3,415)	3
Rush yards	139.6 (1,815)	3
Points scored	29.2 (380)	3
Pass yards against	222.1 (2,887)	16
Rush yards against	78.3 (1,018)	1
Points allowed	15.8 (205)	1

San Francisco's Key Players

Offense

Christian McCaffrey has put up 1,177 rushing yards (first in the NFL) with 12 touchdowns (90.5 yards per game over 13 games). His 5.2 yards per attempt rank third in the NFL.
He's also hauled in 52 passes (on 63 targets) for 437 receiving yards with five touchdowns. He's averaging 33.6 receving yards and four catches per game.
Brock Purdy has thrown for 3,553 yards (third in the NFL), 25 touchdowns (second in the NFL) and seven interceptions this year. He is averaging 273.3 yards per game and 9.9 per attempt, while completing 70.2%.
He's also rushed for 138 yards (fifth on the 49ers) and added two touchdowns on the ground, while averaging 10.6 rushing yards per game.
In 11 games played, Deebo Samuel is averaging 67.2 yards and 4.1 receptions per game to total 739 receiving yards and 45 catches. He's been targeted 62 times, and has four receiving touchdowns.
Brandon Aiyuk has 1,053 receiving yards (ninth in the NFL) and six touchdowns with 56 catches on 81 targets. He is averaging 4.7 receptions and 87.8 yards per game.

Defense

On defense, Fred Warner has four interceptions (fourth in the NFL) to go with 107 tackles, five TFL, two sacks, and nine passes defended in 2023.
Nick Bosa has 45 tackles, 11 TFL, and 9.5 sacks this season.
Dre Greenlaw has recorded 90 tackles, five TFL, and 1.5 sacks this year.
So far this season, Charvarius Ward has 57 tackles, one TFL, and two interceptions. He's fourth on the 49ers in tackles.

Arizona Betting Info

Arizona has covered the spread in a matchup seven times this season (7-6-0).
The Cardinals have been underdogs by 13.5 points or more one time this season and have not covered the spread once.
Arizona games have gone over the total seven times this season.
This season, the Cardinals have won three out of the 13 games, or 23.1%, in which they've been the underdog.
Arizona has played as an underdog of +650 or more once this season and lost that game.
The Cardinals have a 13.3% chance to win this game based on the implied probability of the moneyline.

Cardinals Stats

Stat	Average (Total)	Rank
Pass yards	172.4 (2,241)	30
Rush yards	123.9 (1,611)	9
Points scored	17.7 (230)	26
Pass yards against	216 (2,808)	13
Rush yards against	139.3 (1,811)	30
Points allowed	25.5 (331)	30

Arizona's Key Players

Offense

So far this year through nine games, James Conner has racked up 631 rushing yards (leading the Cardinals) and scored four rushing touchdowns. He averages 70.1 yards per game and 4.9 per attempt (eighth in the NFL).
Marquise Brown has 51 catches for 574 yards and four receiving touchdowns. He has been targeted 101 times and averages 3.9 receptions per game in 13 games played.
Trey McBride has registered 610 receiving yards and two touchdowns on 56 receptions, while being targeted 74 times on the season.
Kyler Murray has 864 passing yards, three touchdowns and two interceptions. His completion percentage is 60.8% and he averages 216 yards per game and 6.6 per attempt.
He has also added 106 rushing yards (fourth on the Cardinals), with three touchdowns on the ground (averaging 26.5 yards per game and 4.6 per carry).

Defense

So far in 2023, Jalen Thompson has one sack to go with four TFL, 62 tackles, and three interceptions through 11 games.
Dennis Gardeck has five sacks (first on the Cardinals) to go with seven TFL and 34 tackles.
Zaven Collins has 3.5 sacks (fourth on the Cardinals) in addition to his five TFL, 31 tackles, and one interception.
Josh Woods has 56 tackles, two TFL, 0.5 sacks, and one pass defended.