49ers vs. Chiefs 2024 Prediction, Odds, Picks - Oct 20

Updated Oct. 20, 2024 12:44 p.m. ET

Data Skrive

Having won one in a row, the Kansas City Chiefs (5-0) will play the San Francisco 49ers (3-3). Despite that, the 49ers are small favorites (-2). The expected point total for the matchup is set at 47.

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49ers vs. Chiefs Odds & Betting Lines

49ers vs Chiefs Betting Information updated as of October 20, 2024, 10:34 a.m. ET.
Favorite	Spread	Favorite Spread Odds	Underdog Spread Odds	Total	Over Total Odds	Under Total Odds
49ers	-2	-108	-112	47	-112	-108

49ers vs. Chiefs Prediction & Pick

Pick ATS: Chiefs (+2)
Pick OU: Under (47)
Prediction: Chiefs 25 - 49ers 19

How to Watch San Francisco vs. Kansas City

Game Date: Sunday, October 20, 2024
Time: 4:25 p.m. ET
Venue: Levi's Stadium
Location: Santa Clara, California
TV: Watch on FOX
Live Boxscore: FOX Sports

49ers vs. Chiefs Recent Matchups

Kansas City holds a 4-1 record against San Francisco in their last five matchups.
In their last five head-to-head matchups, Kansas City has scored 155 points against San Francisco, while allowing only 114 points.

San Francisco Betting Info

San Francisco has three wins in six games versus the spread this season.
The 49ers have covered the spread three times this season (3-3 ATS) when playing as at least 2-point favorites.
San Francisco games this year have hit the over on four of six set point totals (66.7%).
When playing as moneyline favorites, the 49ers have won 50% of the time (3-3).
Looking at this matchup's moneyline, the 49ers' implied win probability is 55.6%.

49ers Stats

Stat	Average (Total)	Rank
Pass yards	262.0 (1,572)	2
Rush yards	158.0 (948)	3
Points scored	27.0 (162)	6
Pass yards against	215.2 (1,291)	17
Rush yards against	101.0 (606)	7
Points allowed	21.7 (130)	12

San Francisco's Key Players

Offense

Brock Purdy has 1,629 passing yards (second in the NFL), nine touchdowns (eighth in the NFL) and four interceptions this year. He has completed 65.4% of his passes, averaging 271.5 yards per game and 8.8 per attempt.
He has also rushed for 127 yards (third on the 49ers) without scoring a touchdown on the ground, while averaging 21.2 rushing yards per game.
Jordan Mason has racked up 609 rushing yards (second in the NFL) with three touchdowns (101.5 yards per game across six games). His 5.3 yards per attempt rank 11th in the NFL.
Mason has eight catches on 10 targets for 75 yards. He has not scored a touchdown in the passing game.
In six games played, Jauan Jennings is averaging 67.3 yards and 4.2 receptions per game on the way to 404 receiving yards (10th in the NFL) and 25 catches. He's been targeted 36 times, and has three receiving touchdowns (10th in the NFL).
George Kittle averages 5.6 receptions and 56.6 yards per game, and has 283 total receiving yards and 28 catches. He's gotten 35 total targets, and has caught five touchdown passes (first in the NFL).

Defense

On the defensive side, Fred Warner has two interceptions (sixth in the NFL) to go with 50 tackles, 2.0 TFL, one sack, and five passes defended in 2024.
Nick Bosa has 22 tackles, 6.0 TFL, three sacks, and one interception this season.
Ji'Ayir Brown has put up 33 tackles and 3.0 TFL this year. He's third on the 49ers in tackles.
Deommodore Lenoir has 32 tackles, 1.0 TFL, and four passes defended.

Kansas City Betting Info

Kansas City has covered the spread in a game three times this season (3-2-0).
This year, Kansas City games have hit the over twice.
This is the first time the Chiefs will play as underdogs this season.
The Chiefs have a 48.8% chance to win this game based on the implied probability of the moneyline.

Chiefs Stats

Stat	Average (Total)	Rank
Pass yards	236.8 (1,184)	9
Rush yards	117.8 (589)	16
Points scored	23.6 (118)	20
Pass yards against	217.0 (1,085)	20
Rush yards against	88.4 (442)	5
Points allowed	17.0 (85)	6

Kansas City's Key Players

Offense

Through five games played this year, Patrick Mahomes has amassed 1,235 passing yards, while throwing six touchdowns against six interceptions and completing 69.4% of his attempts.
On the ground, Mahomes has added 83 rushing yards (fourth on the Chiefs).
Xavier Worthy has put together a 2024 stat sheet that includes 12 catches for 179 yards and two receiving touchdowns in five games played. He has been on the receiving end of 21 targets and is averaging 2.4 receptions per game.
So far this season in two games, Kareem Hunt has churned out 171 rushing yards (leading the Chiefs) and scored one rushing touchdown. He averages 85.5 yards per game and 4.2 per attempt (30th in the NFL).
Hunt's statistic output includes three receptions (1.5 per game) on four targets for 31 yards (15.5 per game), but he has not scored a touchdown through the air.
Travis Kelce has 24 catches for 228 yards without a receiving touchdown. He averages 4.8 yards per game in five games and has been targeted 31 times.

Defense

Nick Bolton has put up 6.0 TFL and 38 tackles over five games in 2024.
Chamarri Conner's stat sheet includes one interception as well as 26 tackles, 1.0 TFL, one sack, and two passes defended.
Bryan Cook has intercepted one pass on top of 26 tackles and four passes defended during the 2024 campaign.
Jaylen Watson has totaled 29 tackles through five games.

FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

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