49ers vs. Chiefs 2024 Prediction, Odds, Picks - Oct 20

Published Oct. 18, 2024 4:43 p.m. ET

Data Skrive

Having won one in a row, the Kansas City Chiefs (5-0) will face the San Francisco 49ers (3-3). Despite that, the 49ers are small favorites (-1.5). The expected point total for the matchup is set at 47.

Keep up with the 2024 NFL season on FOX Sports.

49ers vs. Chiefs preview, Who needs the win more? | First Things First

The Kansas City Chiefs face off with the San Francisco 49ers on Sunday in a pivotal game for both teams. Nick Wright, Chris Broussard, and Kevin Wildes preview the matchup to see who will come out on top.

49ers vs. Chiefs Odds & Betting Lines

49ers vs Chiefs Betting Information updated as of October 18, 2024, 3:34 p.m. ET.
Favorite	Spread	Favorite Spread Odds	Underdog Spread Odds	Total	Over Total Odds	Under Total Odds
49ers	-1.5	-112	-108	47	-112	-108

49ers vs. Chiefs Prediction & Pick

Pick ATS: Chiefs (+1.5)
Pick OU: Under (47)
Prediction: Chiefs 25 - 49ers 19

How to Watch San Francisco vs. Kansas City

Game Date: Sunday, October 20, 2024
Time: 4:25 p.m. ET
Venue: Levi's Stadium
Location: Santa Clara, California
TV: Watch on FOX
Live Boxscore: FOX Sports

49ers vs. Chiefs Recent Matchups

In their past five head-to-head contests, Kansas City has defeated San Francisco four times.
Over their last five head-to-head contests, Kansas City has racked up 155 points, while San Francisco has tallied 114.

San Francisco Betting Info

San Francisco has played six games, posting three wins against the spread.
The 49ers have covered the spread three times this season (3-3 ATS) when playing as at least 1.5-point favorites.
San Francisco games this year have gone over the total in four out of six opportunities (66.7%).
When playing as the moneyline favorite, the 49ers are 3-3 (winning 50% of the time).
The 49ers have a 55.0% chance to win this game, based on the implied probability of the moneyline.

49ers Stats

Stat	Average (Total)	Rank
Pass yards	262 (1,572)	2
Rush yards	158 (948)	3
Points scored	27 (162)	6
Pass yards against	215.2 (1,291)	17
Rush yards against	101 (606)	7
Points allowed	21.7 (130)	12

San Francisco's Key Players

Offense

Brock Purdy has 1,629 passing yards (second in the NFL), nine touchdowns (eighth in the NFL) and four interceptions this year. He has completed 65.4% of his passes, averaging 271.5 yards per game and 8.8 per attempt.
He has also rushed for 127 yards (third on the 49ers) without scoring a touchdown on the ground, while averaging 21.2 rushing yards per game.
Jordan Mason's rushing output this season includes 609 yards (second in the NFL) and three TDs. He is averaging 101.5 yards per game and 5.3 per attempt (11th in the NFL).
He's caught eight passes (on 10 targets) for 75 receiving yards with zero touchdowns. He's averaging 12.5 receiving yards and 1.3 catches per game.
In the passing game, Jauan Jennings, has totaled 404 receiving yards (10th in the NFL) and three touchdowns (10th in the NFL) after catching 25 balls on 36 targets. Per game, he's averaging 67.3 yards and 4.2 receptions in six games.
George Kittle has 28 catches for 283 yards and five touchdowns. He's been targeted 35 times in the air attack, and averages 5.6 receptions and 56.6 yards through five games played.

Defense

Over on defense, Fred Warner has 50 tackles, two TFL, one sack, and two interceptions in 2024.
Nick Bosa has three sacks (second on the 49ers) in addition to his six TFL, 22 tackles, and one interception.
Ji'Ayir Brown has recorded 33 tackles and three TFL this year. He's third on the 49ers in tackles.
So far this season, Deommodore Lenoir has 32 tackles and one TFL.

Kansas City Betting Info

Kansas City has covered the spread three times in five games with a set total.
This season, Kansas City games have hit the over twice.
The Chiefs have not played a game this season while listed as the underdog.
The sportsbooks' moneyline implies a 49.5% chance of a victory for the Chiefs.

Chiefs Stats

Stat	Average (Total)	Rank
Pass yards	236.8 (1,184)	9
Rush yards	117.8 (589)	16
Points scored	23.6 (118)	20
Pass yards against	217 (1,085)	20
Rush yards against	88.4 (442)	5
Points allowed	17 (85)	6

Kansas City's Key Players

Offense

Patrick Mahomes has passed for 1,235 yards this year, with six touchdowns and six interceptions. He is completing 69.4% of his passes while averaging 247 yards per game and 7.7 per attempt.
On the ground, Mahomes has added 83 rushing yards (fourth on the Chiefs).
Xavier Worthy has 12 catches for 179 yards and two receiving touchdowns. He has been targeted 21 times and averages 2.4 receptions per game in five games played.
Kareem Hunt is averaging 85.5 rushing yards per game this season (171 total yards), while scoring one rushing touchdown.
Hunt has helped in the passing attack, putting up 31 receiving yards (15.5 per game) on three catches (1.5 per game), while being targeted four times. He is seeking his first receiving touchdown.
Travis Kelce has 24 catches for 228 yards without a receiving touchdown. He averages 4.8 yards per game through five games and has been targeted 31 times.

Defense

Nick Bolton has recorded six TFL and 38 tackles over five games in 2024.
Chamarri Conner has 26 tackles, one TFL, one sack, and one interception. He is fourth on the Chiefs in tackles.
In the 2024 campaign, Bryan Cook has 26 tackles and one interception in five games.
Jaylen Watson has 29 tackles and six passes defended.

FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

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