49ers vs. Patriots 2024 Prediction, Odds, Picks - Sep 29

Updated Sep. 27, 2024 8:43 p.m. ET

Data Skrive

The San Francisco 49ers (1-2) are favored by 10.5 points versus the New England Patriots (1-2) on September 29, 2024, starting at 4:05 p.m. ET, airing on FOX. An over/under of 40.5 points has been established for the matchup.

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49ers vs. Patriots Odds & Betting Lines

49ers vs Patriots Betting Information updated as of September 27, 2024, 2:34 p.m. ET.
Favorite	Spread	Favorite Spread Odds	Underdog Spread Odds	Total	Over Total Odds	Under Total Odds
49ers	-10.5	-108	-112	40.5	-112	-108

49ers vs. Patriots Prediction & Pick

Pick ATS: Pick Em
Pick OU: Under (40.5)
Prediction: 49ers 25 - Patriots 15

How to Watch San Francisco vs. New England

Game Date: Sunday, September 29, 2024
Time: 4:05 p.m. ET
Venue: Levi's Stadium
Location: Santa Clara, California
TV: Watch on FOX
Live Boxscore: FOX Sports

49ers vs. Patriots Recent Matchups

In their past four head-to-head matchups, New England has beaten San Francisco three times.
Over their last four head-to-head contests, New England has scored 115 points, while San Francisco has accumulated 86.

San Francisco Betting Info

This year San Francisco has one win against the spread.
San Francisco games this year have eclipsed the over/under two times in three opportunities (66.7%).
When playing as moneyline favorites, the 49ers are 1-2 (winning 33.3% of the time).
Based on this contest's moneyline, the 49ers' implied win probability is 85.7%.

49ers Stats

Stat	Average (Total)	Rank
Pass yards	267.7 (803)	1
Rush yards	139.7 (419)	10
Points scored	24.3 (73)	9
Pass yards against	217.7 (653)	20
Rush yards against	104.0 (312)	9
Points allowed	23.0 (69)	21

San Francisco's Key Players

Offense

Brock Purdy has thrown for 842 yards (third in the NFL), four touchdowns (10th in the NFL) and one interception this year. He averages 280.7 yards per game and 8.9 per attempt, while completing 72.6% of his attempts.
In addition to his passing statistics, Purdy also has 64 rushing yards (second on the 49ers), but no touchdowns.
Jordan Mason's rushing statline this season includes 324 yards (second in the NFL) and two TDs. He is averaging 108.0 yards per game and 4.8 per attempt (16th in the NFL).
Jauan Jennings has three touchdown catches this season (first in the NFL), and has 18 catches (10th in the NFL) for 276 yards (fifth in the NFL) on 21 targets, while averaging 6.0 catches and 92.0 yards per game.
Deebo Samuel has 13 receptions for 164 yards and zero touchdowns. He's been targeted 19 times in the air attack, and averages 6.5 receptions and 82.0 yards in two games played.

Defense

On the defensive side for the 49ers, Fred Warner has powered the unit with 20 tackles, 1.0 TFL, one sack, and one interception in 2024.
Nick Bosa has nine tackles, 3.0 TFL, and two sacks this season.
Isaac Yiadom has recorded 13 tackles this year. He's third on the 49ers in tackles.
Charvarius Ward has 13 tackles and three passes defended.

New England Betting Info

New England has put together a record of 2-1-0 against the spread this year.
Games involving New England has hit the over once this year.
The Patriots have entered the game as underdogs three times this season and won once.
The moneyline for this contest implies a 18.5% chance of a victory for the Patriots.

Patriots Stats

Stat	Average (Total)	Rank
Pass yards	102.0 (306)	32
Rush yards	144.3 (433)	8
Points scored	13.0 (39)	31
Pass yards against	244.3 (733)	27
Rush yards against	83.0 (249)	5
Points allowed	19.0 (57)	10

New England's Key Players

Offense

Rhamondre Stevenson averages 74.7 rushing yards per game this year (224 total yards), while scoring two rushing touchdowns.
Through three games, Jacoby Brissett has 368 passing yards, with one touchdown against zero interceptions and completing 60.9% of his attempts.
Brissett also has 38 rushing yards (third on the Patriots).
So far this season in three games, Antonio Gibson has churned out 143 rushing yards (second on the Patriots), but has not scored a rushing touchdown. He averages 47.7 yards per game and 6.2 per attempt (third in the NFL).
Hunter Henry has been targeted 18 times, resulting in 12 catches for 136 yards and zero receiving touchdowns.

Defense

Keion White has recorded 4.0 sacks (first on the Patriots and third in the NFL) to go with 3.0 TFL and 17 tackles over three games in 2024.
Kyle Dugger has 1.0 sack (second on the Patriots) to go with 3.0 TFL and 16 tackles.
Jonathan Jones has 18 tackles in the 2024 campaign. He leads the Patriots in tackles.
Jahlani Tavai has 17 tackles, 2.0 TFL, and one pass defended.

FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

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