49ers vs. Rams 2024 Prediction, Odds, Picks - Dec 12

Updated Dec. 12, 2024 4:43 p.m. ET

Data Skrive

The San Francisco 49ers (6-7) are slim favorites (-2.5) against the Los Angeles Rams (7-6) in a matchup of two division rivals. An over/under of 48 points has been set for the matchup.

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49ers vs. Rams Odds & Betting Lines

49ers vs Rams Betting Information updated as of December 12, 2024, 4:33 p.m. ET.
Favorite	Spread	Favorite Spread Odds	Underdog Spread Odds	Total	Over Total Odds	Under Total Odds
49ers	-2.5	-129	-103	48	-112	-108

49ers vs. Rams Prediction & Pick

Pick ATS: Rams (+2.5)
Pick OU: Under (48)
Prediction: 49ers 25 - Rams 23

How to Watch San Francisco vs. Los Angeles

Game Date: Thursday, December 12, 2024
Time: 8:15 p.m. ET
Venue: Levi's Stadium
Location: Santa Clara, California
TV: Amazon Prime Video
Live Boxscore: FOX Sports

49ers vs. Rams Recent Matchups

In their last five head-to-head bouts, San Francisco has defeated Los Angeles three times.
Los Angeles has been outscored by 35 points in its last five tilts against San Francisco.

San Francisco Betting Info

Against the spread, San Francisco is 5-8-0 this season.
The 49ers have an ATS record of 5-6 when playing as at least 2.5-point favorites this season.
San Francisco contests this year have hit the over 53.8% of the time (seven times in 13 games with a set point total).
When playing as moneyline favorites, the 49ers have won 54.5% of the time (6-5).
Based on this matchup's moneyline, the 49ers' implied win probability is 59.7%.

49ers Stats

Stat	Average (Total)	Rank
Pass yards	239.6 (3,115)	7
Rush yards	138.9 (1,806)	7
Points scored	23.7 (308)	11
Pass yards against	182.6 (2,374)	3
Rush yards against	115.9 (1,507)	12
Points allowed	23.7 (308)	21

San Francisco's Key Players

Offense

Brock Purdy has passed for 3,032 yards, 15 touchdowns and eight interceptions this year. He is averaging 252.7 yards per game and 8.7 per attempt, while completing 66.8% of his passes.
He has tacked on 282 rushing yards (23.5 per game) and four touchdowns on the ground.
George Kittle has 56 catches for 800 yards and eight TDs. Through 11 games, he is averaging 5.1 catches and 72.7 yards per game.
In the passing game, Jauan Jennings, has racked up 774 receiving yards and six touchdowns after catching 57 balls on 78 targets. Per game, he's averaging 70.4 yards and 5.2 receptions through 11 games.
Deebo Samuel averages 3.3 receptions and 46.1 yards per game, and has 553 total receiving yards and 40 catches. He's gotten 64 total targets, and has caught one touchdown pass.

Defense

On defense, Fred Warner has 91 tackles, three TFL, one sack, and two interceptions in 2024.
Nick Bosa has picked off one pass and has added 36 tackles, 10 TFL, seven sacks, and one pass defended.
Leonard Floyd has recorded 36 tackles, eight TFL, and 8.5 sacks this year.
So far this season, Deommodore Lenoir has 68 tackles, two TFL, and two interceptions.

Los Angeles Betting Info

Los Angeles has covered the spread six times in 13 games with a set total.
The Rams have been underdogs by 2.5 points or more seven times this year and are 3-4 ATS in those games.
Los Angeles games have gone over the total seven times this year.
The Rams have won three of the seven games they've played as underdogs this season.
The implied probability of a win by the Rams based on the moneyline is 44.6%.

Rams Stats

Stat	Average (Total)	Rank
Pass yards	237.7 (3,090)	9
Rush yards	103 (1,339)	25
Points scored	22.9 (298)	16
Pass yards against	225.1 (2,926)	24
Rush yards against	141 (1,833)	28
Points allowed	25.5 (332)	24

Los Angeles' Key Players

Offense

Kyren Williams averages 77.9 rushing yards per game this year (1,013 total yards to rank fifth in the NFL), while scoring 12 rushing touchdowns.
On top of his impact on the ground, Williams has caught 28 passes (on 34 targets) for 155 yards (eighth on the Rams), with two receiving touchdowns. He's averaging 11.9 yards per game.
In 13 games, Matthew Stafford has 3,303 passing yards (fifth-best in the NFL), with 19 touchdowns (10th in the NFL) against seven interceptions and completing 66.7% of his passes.
Cooper Kupp has totaled 657 receiving yards and six touchdowns on 63 receptions, while being targeted 91 times this season.
Puka Nacua has 708 receiving yards and three touchdowns from 54 receptions after receiving 75 targets.

Defense

In 2024, Jared Verse has amassed 4.5 sacks to go with 11 TFL and 56 tackles through 13 games.
Christian Rozeboom has 109 tackles, four TFL, and one interception. He leads the Rams in tackles.
Quentin Lake has 96 tackles, one TFL, and two sacks in the 2024 campaign. He is second on the Rams in tackles.
Kobie Turner's season stats include 55 tackles, seven TFL, and five sacks in 13 games. He is fifth on the Rams in tackles.

FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

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