Bills vs. 49ers 2024 Prediction, Odds, Picks - Dec 1

Published Nov. 29, 2024 8:43 p.m. ET

Data Skrive

Having taken six in a row, the Buffalo Bills (9-2) will face the San Francisco 49ers (5-6). The Bills are the favorites, expected to win by at least a field goal but less than a touchdown (currently -6). The predicted point total for the matchup is 44.5.

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Bills vs. 49ers Odds & Betting Lines

Bills vs 49ers Betting Information updated as of November 29, 2024, 8:33 p.m. ET.
Favorite	Spread	Favorite Spread Odds	Underdog Spread Odds	Total	Over Total Odds	Under Total Odds
Bills	-6	-112	-108	44.5	-112	-108

Bills vs. 49ers Prediction & Pick

Pick ATS: Bills (-6)
Pick OU: Over (44.5)
Prediction: Bills 31 - 49ers 17

How to Watch Buffalo vs. San Francisco

Game Date: Sunday, December 1, 2024
Time: 8:20 p.m. ET
Venue: Highmark Stadium
Location: Orchard Park, New York
TV: NBC
Live Boxscore: FOX Sports

Bills vs. 49ers Recent Matchups

San Francisco owns a 3-2 record against Buffalo in their last five matchups.
In their last five head-to-head matchups, San Francisco has racked up 113 points versus Buffalo, while allowing only 92 points.

Buffalo Betting Info

Buffalo has played 11 games, posting seven wins against the spread.
The Bills have been favored by 6 points or more three times this season, and covered the spread in one of those games.
Buffalo has combined with its opponent to gone over the point total in 63.6% of its contests this year (seven times in 11 games with a set point total).
The Bills have won each of the eight games they were listed as the moneyline favorite this season.
Based on this game's moneyline, the Bills' implied win probability is 71.0%.

Bills Stats

Stat	Average (Total)	Rank
Pass yards	226.1 (2,487)	14
Rush yards	119.2 (1,311)	11
Points scored	29.1 (320)	4
Pass yards against	210.0 (2,310)	12
Rush yards against	119.1 (1,310)	14
Points allowed	19.5 (214)	7

Buffalo's Key Players

Offense

Josh Allen has 2,543 passing yards, 18 touchdowns (eighth in the NFL) and five interceptions this year. He has completed 64.0% of his attempts, averaging 231.2 yards per game and 7.5 per attempt.
He has tacked on 316 rushing yards (28.7 per game) and five touchdowns on the ground.
James Cook has put up 596 rushing yards with 10 touchdowns (59.6 yards per game over 10 games). His 4.4 yards per attempt rank 17th in the NFL.
Cook's 31 targets in the passing game have resulted in 25 catches (2.5 per game) for 182 yards (18.2 per game) and one touchdown.
Khalil Shakir has two touchdown catches this season, and has 56 receptions for 599 yards on 66 targets, while averaging 5.6 catches and 59.9 yards per game.
Keon Coleman averages 2.4 receptions and 46.3 yards per game, and has 417 total receiving yards and 22 catches. He's gotten 36 total targets, and has caught three touchdown passes.

Defense

On the defensive side, Dorian Williams has 5.0 TFL and 95 tackles in 2024.
Gregory Rousseau has 37 tackles, 12.0 TFL, and 5.5 sacks this season.
Damar Hamlin has recorded 65 tackles, 2.0 TFL, and two interceptions this year.
So far this season, Terrel Bernard has 57 tackles, 4.0 TFL, one sack, and two interceptions.

San Francisco Betting Info

San Francisco has put together a 4-7-0 record against the spread this year.
The 49ers have been underdogs by 6 points or more one time this year and have not covered the spread once.
Games involving San Francisco have hit the over on six occasions this season.
The 49ers lost the only game they've played as the underdog this season.
The oddsmakers' moneyline implies a 33.3% chance of a victory for the 49ers.

49ers Stats

Stat	Average (Total)	Rank
Pass yards	246.2 (2,708)	4
Rush yards	138.4 (1,522)	7
Points scored	23.6 (260)	14
Pass yards against	193.5 (2,128)	6
Rush yards against	110.8 (1,219)	11
Points allowed	23.6 (260)	20

San Francisco's Key Players

Offense

Brock Purdy has thrown for 2,613 yards this year, with 13 touchdowns and eight interceptions. He is completing 66.0% of his attempts while averaging 261.3 yards per game and 8.5 per attempt.
On the ground, Purdy has added four rushing touchdowns and 267 rushing yards (second on the 49ers).
George Kittle has put together a 2024 campaign that includes 49 catches for 642 yards and eight receiving touchdowns (third in the NFL) in nine games played. He has been on the receiving end of 59 targets and is averaging 5.4 receptions per game.
This season in 11 games, Jordan Mason has churned out 711 rushing yards (leading the 49ers) and scored three rushing touchdowns. He averages 64.6 yards per game and 5.1 per attempt (eighth in the NFL).
Jauan Jennings has been targeted 65 times, resulting in 47 catches for 628 yards .

Defense

So far in 2024, Fred Warner has recorded 84 tackles, 3.0 TFL, one sack, and two interceptions through 11 games.
Nick Bosa has totaled 7.0 sacks in addition to his 10.0 TFL, 36 tackles, and one interception through 10 games.
Deommodore Lenoir has 67 tackles, 2.0 TFL, and two interceptions in the 2024 season. He is second on the 49ers in tackles.
Leonard Floyd has 32 tackles, 6.0 TFL, 6.5 sacks, and one pass defended.

FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

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